Wayne State University

Medicinal Chemistry

Medicinal Chemistry is a multifaceted discipline that encompasses synthetic organic chemistry, natural products chemistry, enzymology, chemical biology, structural biology and computational methods, all of which are aimed at the discovery and development of new therapeutic agents. Medicinal chemistry is by nature an interdisciplinary science, and practitioners have a strong background in organic chemistry, coupled with a broad understanding of biological concepts related to cellular drug targets. Scientists in the field are well positioned to work as part of an interdisciplinary team that uses chemical structural principles to design effective drugs and diagnostic agents.

Graduate coursework within the department includes a broad exposure to various areas within the pharmaceutical sciences (core curriculum) as well as also intensive specialization within the area of students' research interests. Thus, graduates from the Department of Pharmaceutical Sciences are well-rounded in all facets of the discipline and capable specialists in the area of their research. The Pharmaceutical Sciences Ph.D. does not require a minor for graduation.

Core Curriculum

In addition to meeting course requirements as outlined in the Graduate Bulletin, all graduate students are required to register for selected courses from the list below. Note that PSC 6800 is a full semester course, while PSC 7010, 7020, 7030, 7700, 7710 and 7720 are eight-week mini courses.

These courses are required for all pharmaceutical sciences graduate students:

  • PSC 6800 Introduction to Research (2 cr)
  • PSC 7010 Advanced Drug Action and Safety I (2 cr)
  • PSC 7020 Advanced Drug Discovery I (2 cr)
  • PSC 7040 Advanced Drug Formulation and Delivery I (2 cr)

Required Advanced Course

All students must select one (1) advanced course from the list below:

  • PSC 7700 Advanced Drug Action and Safety II (2 cr)
  • PSC 7710 Advanced Drug Discovery II (2 cr)
  • PSC 7720 Advanced Drug Formulation and Delivery II (2 cr)

Medicinal Chemistry Electives

  • PSC 6000 Fundamentals of Drug Design
  • PSC 7850 Seminar in Medicinal Chemistry
  • PSC 7800 Research Techniques in Medicinal Chemistry
  • PSC 8650 Special Topics in Medicinal Chemistry

Relevant Courses Offered by Other Departments 

  • BMB 7010 General Biochemistry Lecture
  • BIO 6160 Molecular and Cellular Biophysics
  • CHM 6440 Computational Chemistry
  • CHM 7200 Organic Structures and Mechanisms
  • CHM 7220 Organic Reactions and Synthesis
  • CHM 7240 Organic Spectroscopy
  • CHM 7410 Statistical Thermodynamics
  • CHM 7430 Chemical Kinetics
  • CHM 7620 Metabolism: Pathways & Regulations
  • CHM 7640 Molecular Biology
  • CHM 7660 Biomolecular Interactions
  • PPR 7670 Clinical Pharmacokinetics
  • PSL 7010 Graduate Physiology I
  • PSL 7011 Graduate Physiology II
  • PSL 7600 Advanced Cardiovascular Physiology
  • PSL 7660 Neurophysiology
  • PSY 5050 Physiological Psychology
  • PSY 7090 Theories of Learning
  • PSY 7120 Biological Basis of Behavior
  • PSY 8080 Memory & Brain
  • CHE5350 Polymer Science
  • CHE7350 Polymer Solutions
  • CHE7370 Biomaterial Interfaces
  • BME 5310 Engineering Principles of Drug Delivery
  • BME 5320 Colloids and Interfaces: Fundamentals and Biomedical Applications
  • IBS7010 Biomedical Molecular Biology
  • IBS7020 Biomedical Cell Biology
  • PHC7210 Fundamentals of Cancer Biology
  • PHC7220 Cell and Molecular Biology of Cancer Development
  • RAD7000 Imaging Physics I
  • BIO5640 Cancer Biology
  • BIO6000 Molecular Cell Biology
  • PSL7215 Nanobioscience
  • MBG7010 Molecular Biology and Genetics
  • BMS 6100 Business of Biotechnology