Steven M. Firestine Ph.D.
EACPHS, Room 3142
Associate Professor, Department of Pharmaceutical Sciences
Degrees and Certifications
B.S. Chemistry - University of Michigan, Ann Arbor MI
PhD. Medicinal Chemistry - Purdue University, West Lafayette IN
Postdoc Enzymology - Pennsylvania State University, University Park PA
Positions and Employment
1988-1990 Undergraduate Research Assistant (Dr. James K. Coward), University of Michigan,
Ann Arbor, MI
1990-1995 Graduate Research Assistant (Dr. V. Jo Davission), Purdue University , West Lafayette, IN
1996-2000 Postdoctoral Fellow (Dr. Stephen J. Benkovic), The Pennsylvania State University,
University Park, PA
2000-2005 Assistant Professor of Medicinal Chemistry, Duquesne University Mylan School of Pharmacy, Pittsburgh PA
2005-2010 Assistant Professor of Medicinal Chemistry, Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI
2010-present Associate Professor of Medicinal Chemistry, Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI
Awards and Honors
1989 Gomberg Summer Research Fellowship, University of Michigan
1990 Merck Award, University of Michigan
1992-1993 NIH Predoctoral Training grant, Purdue University
1994-1995 American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship, Purdue University
1995 Jenkins/Knevel Award for Outstanding Graduate Research, Purdue University
1996-1999 Damon Runyon-Walter Winchell Fellowship, Penn State
1999 ASBMB Travel Award, Penn State
2005 Outstanding Young Investigator, Duquesne University
Primary Research Interest
Antiinfective Drug Discovery; Organic Chemistry; Biochemistry; Chemical Biology
- Vooturi, S.K. and Firestine, S.M. Synthetic Membrane-Targeted Antibiotics. Curr. Med. Chem.,. 2010, 17, 2292-2300.
- Thoden, J.B., Holden, H.M., Paritala, H., and Firestine, S.M. Structure and Site-Directed Mutagenesis ofAspergillus clavatus N5-Carboxylaminoimidazole Ribonucleotide Synthetase. Biochemistry, 2010, 49, 752-60.
- Paritala, H. and Firestine, S.M. Characterization of insulin ILPR sequences for their ability to adopt a G-quadruplex structure. Nucleosides Nucleotides Nucleic Acids, 2010, 29, 81-90.
- Vooturi, S.K. and Firestine, S.M.* Solution-Phase Parallel Synthesis of Novel Membrane-Targeted Antibiotics. J. Comb. Chem., 2010, 12, 151-160.
- Vooturi, S.K., Cheung, C.M. Rybak, M.J., and Firestine, S.M.* Design, Synthesis, and Structure-Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents. J. Med. Chem., 52, 5020-5031,2009.
- Paritala, H., and Firestine, S.M.* Benzo(h)quinoline derivatives as G-quadruplex binding agents. Bio. Med. Chem. Let., 19, 1584-1587, 2009.
- Firestine, S.M.*, Paritala, H., McDonnell, J.E., Thoden, J. and Holden, H.M. Identification of Inhibitors of N5-Carboxylaminoimidazole Ribonucleotide Synthetase by High-throughput Screening. Bio. Med. Chem., 17, 3317-3323, 2009.
- Firestine, S.M.*, Wu, W., Youn, H. and Davisson, V.J. Interrogating the Mechanism of a Tight Binding Inhibitor of AIR Carboxylase. Bio. Med. Chem., 17, 794-803, 2009.
- Thoden, J.B., Holden, H.M.* and Firestine, S.M.* Structural Analysis of the Active Site Geometry of N5-Carboxyaminoimidazole Ribonucleotide Synthetase from Escherichia coli. Biochemistry, 47, 1334613353, 2008.
- Mamidyala, S.K. and Firestine, S.M.* Advances in Herpes Simplex Virus Antiviral Therapy, Expert Opinions in Therapeutic Patents, 16, 1463-1480, 2006.
- Mamidyala, S.K. and Firestine, S.M.* Fluorous-phase synthesis of minor groove binding agents related to distamycin, Tet. Let., 47, 7431-7434, 2006.
- Bednarski, D. and Firestine, S.M. * Regulation of transcription by synthetic DNA bending agents. ChemBioChem,7, 1715-1721, 2006.
- Mueller Stein, S.A., Loccisano, A.E., Firestine, S.M. and Evanseck, J.D.* Principal component analysis: a review of its application on molecular dynamics data. Ann. Rep. Comp. Chem., 2, 234-255, 2006.
- Hooda, J. Bednarski, D., Irish, L. and Firestine, S.M.* Synthesis and testing of a Triaza-Cyclopenta[b]phenanthrene scaffold as a DNA binding agent. Bio. Med. Chem. 14, 1902-1909, 2006.
Poster and Oral Presentations: Over 75 presentations.