Jiemei Wang M.D., Ph.D.

Jiemei Wang M.D., Ph.D.

Assistant Professor, Pharmaceutical Sciences

Contact

313-577-1715
jiemei.wang@wayne.edu

Office location

EACPHS, Suite 3122

Department

Pharmaceutical Sciences

Appointments

Assistant Professor
Department of Pharmaceutical Sciences
Eugene Applebaum College of Pharmacy and Health Sciences

Degrees and Certifications

  • 2009: Ph.D., Internal Medicine (Cardiology), Sun Yat-Sen University, Guangzhou, China
  • 2004: M.D., Clinical Medicine, Sun Yat-Sen University, Guangzhou, China
  • 2010: AHA Postdoctal fellowship, University of Pittsburgh, Pittsburgh, PA, USA

Positions and Employment

  • 2016.5 - present: Assistant Professor, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI
  • 2014.7 - 2016.5: Assistant Professor - Research, Center for Molecular Medicine & Genetics Wayne State University, Detroit, MI
  • 2012 - 2014.7: Research Instructor and Research Assistant Professor, Department of Surgery, University of Pittsburgh, Pittsburgh, PA
  • 2011 - 2015: Research Associate, VA Vascular Surgery Research VA Pittsburgh Healthcare System Pittsburgh, PA

Awards and Honors

  • 2011: Distinguished Speaker, 4th Annual Translational to Clinical (T2C) Wound Care Conference. Columbia, OH.
  • 2010: The Wound Biotechnology Foundation Travel Award for Trainees, Wound Healing Society. Orlando, FL.
  • 2010: Second place in Basic Science, The American Heart Association and the Fellows Research Day, Pittsburgh, PA.
  • 2009: American Heart Association (AHA) Postdoctoral Fellowship Award, Pittsburgh, PA.
  • 2008: Scientific Sessions Merit Travel Award For Young Investigators, American Heart Association, New Orleans, LA
  • 2007: China Overseas Doctoral Scholarship Award, Guangzhou, China.
  • 2004: Physician Excellence Training Award, Sun Yat-Sen University, Guangzhou, China

Professional Memberships

  • American Heart Association
  • Wound Healing Society
  • American Society for Pharmacology and Experimental Therapeutics
  • American Diabetes Association
  • American Physiology Society
  • Rho Chi Society

Areas of Expertise

  • Diabetes
  • Cardiovascular disorders
  • Angiogenesis
  • Endothelium
  • Stress signaling

Primary Research Interest

There are two major focuses in my research:

  1. Non-coding RNA regulation of tissue regeneration. MicroRNAs are newly discovered short oligonucleotides that act as key regulators of gene expression. It is until recently that the importance of microRNA-directed gene regulation in vascular disorders has been recognized. Our project is to determine the biogenesis of miRNAs and their impact on tissue repair, in response to detrimental stress, such as diabetes, hyperlipidemia, hypertension, etc. We are working on new projects to look at some of the long non-coding RNAs (lncRNA) in regulation of anigogenesis as well.
  2. Endothelial injury and repair in disease settings. The well-being of vascular endothelium is essential to normal vascular homeostasis. Its dysfunction is one of the first steps leading to atherosclerosis. Endothelial progenitor cells (EPCs) are vascular endothelial cell (EC) precursors that are capable of differentiating into mature endothelial cells and producing new vessels but their functions are impaired in various cardiovascular diseases. We are investigating the morphogenic activities of EPCs that might contribute to EPCs’ therapeutic potentials for wound healing.

Recent Publications

Wang JM*, Qiu Y, Zhao Y, Kim HB, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yin L*, Zhang K*. Inositol Requiring Enzyme 1 Prevents Hepatic Steatosis through Processing MicroRNAs. (*: Co-Corresponding author), Science Signaling 2018, Online. Impact factor: 6.494.

Farooq SM, Hou Y, Li H, Wang Y, Li CY*, Wang JM*. Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-induced Colitis in Mice. (*: Co-Corresponding author), Digestive Diseases and Sciences, 63(11):2910-2922, 2018. Impact factor: 2.875

Sun H, Lee P, Yan C, Gao N, Wang JM, Fan X, Yu FS. Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas. Diabetes 67(8), 1162-1172, 2018. Impact factor: 8.784.

Zhang K, Kim H, Fu Z, Qiu Y, Yang Z, Wang JM, Zhang D, Tong X, Yin L, Li J, Wu J, Qi NR, Houten SM, Zhang R. Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice. Gastroenterology 154(1): 224-237, 2018. Impact factor: 18.392
Li H, Liu J, Wang Y, Fu Z, Huttemann M, Monks TJ, Chen AF, Wang JM*. MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in type 2 diabetes. American Journal of Physiology-Endocrinology and Metabolism 313: E391-E401, 2017 (*: Corresponding author). Impact factor: 4.142

Wang JM*, Qiu YN, Yang ZQ, Li L, Zhang K*. Inositol requiring enzyme 1α facilitates diabetic wound healing through modulating microRNAs. Diabetes 66:177-192, 2017. (*: Corresponding author) Impact factor: 8.784.

Wang JM*, Chen AF, Zhang KZ. Isolation and primary culture of mouse aortic endothelial cells. J Vis Exp 118:e52965, 2016. (*: Corresponding author)

Wang JM*, Zhang KZ. Microarray analysis of microRNA expression in bone marrow-derived progenitor cells from mice with type 2 diabetes. Genomics Data 23:86-87, 2015. (*: Corresponding author)

Wang JM, Tao J, Chen DD, Cai JJ, Wang QD, Irani K, Yuan H, Chen AF. MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology. 34:99-109,2014. Impact factor: 6.607

Wang JM, Isenberg JS, Billiar TR, Chen AF. Thrombospondin-1/CD36 Pathway Contributes to Bone Marrow-Derived Angiogenic Cell Dysfunction in Type 1 Diabetes via Sonic Hedgehog Pathway Suppression. American Journal of Physiology-Endocrinology and Metabolism. 305:E1464-1472, 2013. Impact factor: 3.925

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