Positions and Employment
- Associate Professor, Institute of Environmental Health Sciences
Primary Research Interest
Immunosuppression: The drugs that made organ transplantation possible are immunosuppressants that inhibit Calcineurin Phosphatase activity. The mechanism of action of those drugs, Cyclosporin-A and Tacrolimus, remains an active area of research. The integration of regulatory mechanisms to control phosphates activity and drug action is studied in my laboratory using manufactured proteins and assays directed at the five mechanisms regulating calcineurin activity.
- Feng, B. and Stemmer, P.M.: Interactions of Calcineurin A, Calcineurin B, and Ca(2+). Biochemistry 38:12481-12489, 1999.
- Persechini, A., Yano, K. and Stemmer, P.M.: Ca2+ binding and energy coupling in the calmodulin-myosin light chain complex. J. Biol. Chem. 275: 4199-204, 2000.
- Sommer, D. and Stemmer, P.M.: Modulation of calcineurin activity by oxidants and antioxidants. Eur. J. Biochem., 267: 2312-2322, 2000.
- Stemmer, P.M., Ledyard, T.H. and Watanabe, A.M.: Protein dephosphorylation rates in myocytes after isoproterenol withdraw. Biochem. Pharmacol., 59: 1513-1519, 2000.
- Feng, B. and Stemmer, P.M.: Ca2+-binding site 2 in calcineurin-B modulates calmodulin-dependent calcineurin phosphatase activity. Biochemistry, 40: 8808-8814, 2001.
- Persechini, A and Stemmer, P.M.: Calmodulin is a Limiting Factor in the Cell. Trends in Cardiovascular Med., 12: 32-37, 2002.
- Sommer, D., Coleman, S., Swanson, S.A. and Stemmer, P.M.: Differential Susceptibilities of Serine/Threonine Phosphatases to Oxidative and Nitrosative Stress, Arch Biochem Biophys., 404: 271-278, 2002.
- Ohashi, I., Pohoreki, R., Morita, K. and Stemmer, P.M.: Alcohols increase calmodulin affinity for Ca2+ and decrease target affinity for calmodulin. Biochimica et Biophysica Acta. 1691: 161-167, 2004.
- Rai, A.J., Stemmer, P.M., Zhang, Z., Morgan, B., Caffrey, B.R., Podusk, V., Leung, E.H.C.: Analysis of HUPO-PPP Reference Specimens using SELDI-TOF Mass Spectrometry: Multi-Institution Correlation of Spectra and Identification of Biomarkers. Proteomics, In Press.