Terrence J. Monks

Terrence J. Monks

Title

Professor

Department

Pharmaceutical Sciences

Office Location

EACPHS, Room 5148

Phone

313-577-1935

Email

terrence.monks@wayne.edu

Terrence J. Monks

Degrees and Certifications

  • B.Sc. 1st Class Honors, Applied Biology – Major in Biochem (Valedictorian), The Hatfield Polytechnic (University of Hertfordshire), Hatfield, Hertfordshire, England
  • Ph.D. – Biochemical Pharmacology, St. Mary’s Hospital Medical School, University of London
    Thesis title: Metabolism and Pharmacokinetics of Theophylline and Aminophylline

Positions and Employment

Current appointments

Before joining Wayne State University in 2016, Terrence Monks was a professor of carcinogenesis at the University of Texas M. D. Anderson Cancer Center; professor of pharmacology and toxicology at University of Texas at Austin, where he founded the Center for Molecular and Cellular Toxicology; and professor and chair of pharmacology and toxicology, as well as associate dean for research and graduate studies for the College of Pharmacy, at the University of Arizona Health Sciences Center. He also served as director of the Center for Research on Environmental Disease's Mechanisms of Chemical-Induced Cell Death Research Core and the Southwest Environmental Health Sciences Center's ROS and Disease Prevention Research Core.

Dr. Monks is on the editorial board of Chemical-Biological Interactions. He has been a member of the University of Iowa Superfund Basic Research Program External Advisory Board since 2005, and he also serves on the HESI (Health and Environmental Sciences Institute Emerging Issues Committee and the Society of Toxicology Membership Committee, an elected position.

Awards and Honors

  • 1975: Departmental Award for the top graduate (Valedictorian) Biology Department, Hatfield Polytechnic, Hatfield, Hertfordshire England (currently the University of Hertfordshire)
  • 1975-1978: Medical Research Council (U.K.) Scholarship
  • 1986: Best Paper Award, Drug Metabolism and Disposition. Awarded by the Drug Metabolism Division of the American Society of Pharmacology and Experimental Therapeutics. Paper entitled “Glutathione Conjugates of 2-Bromohydroquinone are Nephrotoxic.”
  • 1988: Nomination for Best Paper Award, Drug Metabolism and Disposition. Awarded by the Drug Metabolism Division of the American Society of Pharmacology and Experimental Therapeutics. Paper entitled “Cooxidation of 2-bromohydroquinone by renal prostaglandin synthase. Modulation of prostaglandin synthesis by 2- bromohydroquinone and glutathione.”
  • 1993: Zeneca Traveling Lectureship, administered by the U.S. Society of Toxicology
  • 1994: Paper titled “Developmental toxicity of 2-bromohydroquinone (BHQ) and BHQ- glutathione conjugates in vivo and in whole embryo culture” (Toxicol. Appl. Pharm. 120,1-7, 1993) nominated for the Scientific and Technical Achievement Award, United States Environmental Protection Agency
  • 1995/96: Vice Chair/Chair, Gordon Research Conference on Drug Metabolism
  • 2001: Morton J. Rodman Distinguished Professorship in Pharmacology, Dept. of Pharmacology and Toxicology, Rutgers College of Pharmacy and the Joint Graduate Program in Toxicology of Rutgers, The State University of New Jersey, The University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School
  • 2008: Fellow of the Academy of Toxicological Sciences
  • 2016: Nominee for President of the American Society for Pharmacology & Experimental Therapeutics (ASPET)

Recent grant support

“Human Disease and the Interplay Between Genes and the Environment” (2008-2013)
T32 ES16652, 07/01/08 - 06/30/13 ($1,367,520 Total Costs)
NIEHS Training Grant
Principal Investigator: T.J. Monks.

“Hepatic Metabolism and Susceptibility to Ecstasy Toxicity” (2008-2013)
RO1 DA023525 09/30/08 - 05/31/13 ($1,672,983 Total Costs)
Principal Investigator: T.J. Monks.

“Mechanisms Underlying Benzene-Induced Occupational and Environmental Leukemia” (2013-15)
Skaggs Foundation Scholars Program
PIs: T.J. Monks, S.S. Lau, and D. Ross (Univ Colorado)
$150,000 Direct Costs

“Synthesis and Preliminary Immunotoxicological Activity of Arsenic-GSH Conjugates” (2014)
SWEHSC Pilot Project
PIs: T.J. Monks, E. Tomat, S. Burchiel (Univ. New Mexico)
$40,000 Direct Costs

“Alleviating Reactive Carbonyl Species-Induced progenitor cell Dysfunction in Diabetic Wound Healing” (2019)
12th Percentile
RO1 DK119222-A1 07/01/19 – 06/30/24
PIs: T.J. Monks and J. Wang (Corresponding PI)

Professional Memberships

  • American Society of Pharmacology and Experimental Therapeutics (ASPET)
  • Society of Toxicology (SOT)
  • International Society for the Study of Xenobiotics (ISSX)
  • American Association of Colleges of Pharmacy (AACP)
    • AACP Academic Research Fellow (2014)

Wayne State service activities

Recent Publications

  • Cohen, J.D, Labenski, M., Mastrandrea, N.J., Canatsey, R.D., Monks, T.J., and Lau, S.S. Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma. Molec. Carcinogenesis, 55, 1243-1250, 2016. PMID: 26333016.
  • Kinsky, O.R., Hargraves, T.L., Anumol, T., Jacobsen, N., Dai, J., Snyder, S., Monks, T.J., and Lau, S.S. Metformin scavenges to form a novel imidazolinone metabolite in humans. Chem. Res. Toxicol. 29, 227-234, 2016. PMID 26771051, Cover Image.
  • Cholanians, A.B., Phan, A.V., Ditzel, E.J., Camenisch, T.D., Lau, S.S. and Monks, T.J. Arsenic induces accumulation of α-synuclein: Implications for synucleinopathies and neurodegeneration. Toxicol. Sci., 153, 271-281, 2016. PMID 27413109 Cover Image.
  • Cho, S., Islas-Robles, A., Nicolini, A.M., Monks, T.J., and Yoon, J-Y. In situ, dual-mode monitoring of organ-on-a-chip with a smartphone-based fluorescence microscope. Biosensors and Bioelectronics PMID 27474967 (IF 7.47), 86, 697-705, 2016.
  • Xu, K., Radabaugh, T, Lu, Z., Galligan, M., Billheimer, D., Vercelli, D., Wright, A.L., Monks, T.J., Halonen, M., and Lau, S.S. Exploration of early-life candidate biomarkers for childhood asthma using antibody arrays. Pediatric Allergy and Immunology, 27, 696-701, 2016. PMID 27434124.
  • Eddington, N.D., Aube, J., Das, S.K., Ellingrod, V.L., Hansen, R., Madhavan, S.S., Monks, T.J., Morris, M.M., and Lakowski, J.M. Report of the 2014-2016 AACP Research and Graduate Affairs Committee. Am. J. Pharm. Edu., 80, S21, 2016. PMID 28090116.
  • Munoz, F .M., Zhang, F ., Islas-Robles, A., Lau, S.S., and Monks, T .J. ROS-induced store- operated Ca2+ entry coupled to PARP-1 hyperactivation is independent of PARG activity in necrotic cell death. Tox Sci., 158, 444-453, 2017, PMID 28525621. Cover Image.
  • Sapiro, J.M., Lau, S.S., and Monks, T.J. Activation of p-ERK initiates all-trans retinoic acid- mediated cytoprotection in renal epithelial cells. Am J Physiol. Renal Physiol, 313, F1200- F1208, 2017, PMID 28768661.
  • Li, H., Wang, Y., Fu, Z., Monks, T.J., Chen, A., and Wang, J-M. MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in type 2 diabetes. Am J Physiol. Endocrinology & Metab., 313, E391-E401, 2017, PMID 28698281.
  • Zhang, F ., Munoz, F ., Sun, L., Zhang, S., Lau, S.S., and Monks, T .J. Cell specific regulation of Nrf2 during ROS-dependent cell death caused by 2,3,5-tris(glutathione-S-yl)hydroquinone. Chem-Biol Interact., 302, 1-10, 2019, PMID 30703377
  • Li, H., O’Meara, M., Zhang, X., Zhang, K., Seyoun, B., Yi, Z., Kuafman, R.J., Monks, T.j., and Wang, J-M. Ameliorating methylglyoxal-induced progenitor cell dysfunction for tissue repair in diabetes. Diabetes, 68, 1287-1302, 2019, PMID 30885990.
  • Cholanians, A.B., Lizarraga, L.E., Phan, A.V., Lau, S.S. and Monks, T.J. Concurrent inhibition of the vesicular monoamine transporter 2 does not protect against 3,4-(±)-methylenedioxy-amphetamine (MDMA, Ecstacy) induced serotonergic neurotoxicity. Toxicol. Sci., In press kfz085, 2019, PMID 30923810.
  • Islas-Robles, A., Yedlapudi, D., Lau, S.S., and Monks, T.J. Proteomic analysis of poly(ADP-ribose)-associated proteins induced by oxidative stress in human proximal tubule cells. In Press kfz131, Toxicol. Sci., 2019, PMID31165168.
  • Sapiro, J.M., Gurdziel, K.G., Lau, S.S., and Monks, T.J. Profiling of p-ERK mediated signaling in all-trans retinoic acid-mediated cytoprotection. Submitted to Chem-Biol Interact, February 2019.