Christine Rabinak Ph.D.

Christine Rabinak Ph.D.

Title

Associate Professor

Department

Pharmacy Practice

Office Location

EACPHS, Room 2136

Phone

313-577-9875

Email

rabinak@wayne.edu

Christine Rabinak Ph.D.

Degrees and Certifications

Degrees

  • 2009 - Ph.D. in Biological Psychology, University of Michigan
  • 2006 - M.S. in Biological Psychology, University of Michigan
  • 2004 - B.S. in Psychology, University of Iowa

Certification

  • United States Department of Justice, Controlled Substance Registration Certificate Research (II-V), Drug Enforcement Administration (active)

Positions and Employment

  • 2019-Present - Associate Professor, Wayne State University
  • 2014-Present - Graduate Faculty, School of Medicine & the Graduate School, Translational Neuroscience Program
  • 2014-Present - Adjunct Assistant Professor, Department of Pharmaceutical Sciences
  • 2014-Present - Adjunct Assistant Professor, School of Medicine, Department of Psychiatry & Behavioral Neurosciences
  • 2014-2019 - Assistant Professor, Wayne State University
  • 2013-2014 - Research Assistant Professor, University of Michigan
  • 2010-2013 - Postdoctoral Research Fellow, University of Michigan
  • 2009-2010 - Research Associate, University of Michigan
  • 2009 - Junior Research Scientist, New York University

Awards and Honors

  • 2019 - Excellence in Postdoctoral Mentorship Award, Graduate School, Wayne State University
  • 2018 - 15th Annual College Research Day Junior Faculty Research Award, Wayne State University
  • 2018 - Elected as an Associate Member to the American College of Neuropsychopharmacology
  • 2017 - NAMI Michigan Investigator, Brain & Behavior Research Foundation’s Research Partners Program
  • 2017 - American Pharmacists Association-Academy of Student Pharmacists (APhA-APS), “Outstanding Faculty Member”, Wayne State University Chapter
  • 2016 - Wayne State University OVPR Faculty Competition for Postdoctoral Fellows
  • 2015 - Nominated by WSU OVPR to submit an application to the Searle Scholars Program
  • 2015 - Member, The Rho Chi Honor Society (The Academic Honor Society in Pharmacy)
  • 2015 - Featured Faculty Researcher in the WSU EACPHS Dean’s Note
  • 2015 - Wayne State University Research Mentor’s Program for New Faculty

Professional Memberships

  • Society for Neuroscience (SFN)
  • Anxiety Disorders Association of America (ADAA)
  • International Cannabinoid Research Society (ICRS)
  • Society of Biological Psychiatry (SOBP)
  • Brain Research and Integrative Neuroscience Network (BRAINnet)
  • American Association of Colleges of Pharmacy (AACP)
  • College of Psychiatric & Neurologic Pharmacists (CPNP)

Areas of Expertise

  • Behavioral and neurobiological mechanisms of aversive learning and memory, threat perception and emotion regulation
  • Cannabinoid involvement during fear extinction learning and retention
  • Biomarkers of development, maintenance and treatment of posttraumatic stress disorder (PTSD) and anxiety disorders

Primary Research Interest

Research In Progress

  • 2019-2024 - National Institute of Mental Health, Mentored Research Scientist Development Award, K01, (04/01/2019-03/31/2024, $806,651); Hilary Marusak (PI), “Endocannabinoid Signaling and the Development of Fear Extinction Recall during Adolescence”
  • 2018-2023 - Veteran Affairs Career Development Program (CDA-2), 1IKRX002686 (06/01/2018-05/31/2023; $721,346 direct costs); Veronica Chui (PI), “Comorbidity of PTSD and Alcohol Dependence: Endocannabinoid Regulation”
  • 2018-2020 Wayne State University, Office of the Vice President for Research Faculty Competition for Postdoctoral Fellows (2018-2020; $60,000 direct costs), “Endocannabinoid Mechanisms Underlying Fear Extinction & Neural Circuits in PTSD”
  • 2018 - Wayne State University, Graduate School, Broadening Experiences in Scientific Training (BEST) Program Grant from WSU’S NIH BEST Institutional Grant, DP7OD018427 (04/01/2018-08/01/2018; $4,000); Alana Conti (PI), “Career Opportunities Outside of Academia for Students in Neuroscience: A Series of Personal and Career Perspectives”
  • 2017-2022 - National Institutes of Mental Health, NIH Exploratory Clinical Trials of Novel Interventions for Mental Disorders, R61MH111935 (02/24/2017-02/23/2022; $2,629,881 direct costs), “Effects of THC on Retention of Memory for Fear Extinction Learning in PTSD”
  • 2017-2019 - Brain & Behavior Research Foundation, NARSAD Young Investigator Grant (01/15/2017-01/14/2019; $70,000 direct costs [NCE 07/14/2019]), “Effects of FAAH Genotype on Fear-Related Brain Activation during Fear Extinction”
  • 2016-2019 - American Cancer Society Postdoctoral Fellowship, PF-16-057-01-PCSM (07/01/2016-06/30/2019; $163,500 direct costs), Hilary Marusak (PI), “Neurobehavioral Correlates of Learning and Memory in Child Cancer Survivors”

Completed Research

  • 2017-2019 - Australian Catholic University (AUC), AUC Women in Health and Medical Research Grant (01/02/2017-01/02/2019; $50,000 direct costs), Izelle Labuschagne (PI), “Epigenetic and hormonal influences on brain mechanisms underlying sex differences in human social behavior: a pilot study”
  • 2017-2018 - St. Baldrick’s Foundation, Supportive Care Research Grants, #523497, (07/01/2017-06/30/2018; $50,000 direct costs); Hilary Marusak (PI), “Martial Arts Therapy and Brain Mechanisms for Cancer-Related Pain”
  • 2014-2018 - National Institutes of Mental Health, Mentored Research Scientist Development Award, K01MH101123 (04/01/2014-03/31/2018; $604,569 direct costs), “Cannabinoid Control of Fear Extinction Neural Circuits in Post-Traumatic Stress Disorder”
  • 2016-2017 - Barbara Ann Karmanos Cancer Institute, Pilot Project Grant from the American Cancer Society Institutional Research Grant IRG#: 14-238-04-IRG, (09/01/2016-08/31/2017; $30,000 direct costs), “Understanding Emotional Brain Network Organization in Survivors of Childhood Cancer”
  • 2016-2019 - National Institutes of Mental Health, Ruth L. Kirschstein National Service Award, F32MH111117 (07/01/2016-06/30/2019; $152,070 direct costs); Hilary Marusak (PI), “Effects of Childhood Victimization on the Neural and Behavioral Mechanisms Underlying Fear Extinction in Adolescents”; Impact Score: 29, 16th percentile; FUNDED but already funded by another postdoctoral fellowship so returned to NIH
  • 2014-2015 - Michigan Institute for Clinical & Health Related Research, MICHR T2 Translational Science Award (02/01/2014-01/31/2015; $50,000 direct costs), “Neural Mechanisms Underlying Attentional Training in Social Anxiety Disorder”

Recent Publications

Please see Dr. Rabinak's bibliography on PubMed for a current list of publications.

  • Rabinak, C.A., Blanchette, A., Zabik, N., Peters, C, Marusak, H.A., Iadipaolo, A., & Elrahal, F. (2020). Cannabinoid modulcation of corticolimbic activation to threat In trauma-exposed adults: a preliminary study. Psychopharmacology, https://doi.org/10.1007/s00213-020-05499-8
  • Hehr, A., Marusak, H.A., Huntley, E.D. & Rabinak, C.A. (2019). Effects of duration and midpoint of sleep on cortico-limbic circuitry in youth. Chronic Stress, 3, 1-14.
  • Marusak.H.A., Harper, F.W., Taub, J.W., & Rabinak, C.A. (11 July 2019). Pediatric cancer, posttraumatic stress, and fear-related neural circuitry. International Journal of Hematologic Oncology, https://doi.org/10.2217/ijh-2019-0002
  • Hammoud, M.Z., Peters, C., Hatfield, J.R.B., Gorka, S., Phan, K.L., Milad, M.R., & Rabinak, C.A. (2019 May 16). Influence of Δ9-tetrahydrocannabinol on long-term neural correlates of threat extinction memory retention in humans. Neuropsychopharmacology, https://doi.org/10.1038/s41386-019-0416-6
  • Rabinak, C.A. (2015). Classical Conditioning. In I. Milosevic & R.E. McCabe (Eds.), Phobias: The Psychology of Irrational Fear, An Encyclopedia (74-75). Santa Barbara, CA: Greenwood.
  • Mori, S. & Rabinak, C.A. (2015). Extinction. In I. Milosevic & R.E. McCabe (Eds.), Phobias: The Psychology of Irrational Fear, An Encyclopedia (144-145). Santa Barbara, CA: Greenwood.
  • Greco, J.A. & Rabinak, C.A. (2015). Fear, Neural pathways of. In I. Milosevic & R.E. McCabe (Eds.), Phobias: The Psychology of Irrational Fear, An Encyclopedia (160-163). Santa Barbara, CA: Greenwood.
  • Mori, S. & Rabinak, C.A. (2015). Amygdala. In I. Milosevic & R.E. McCabe (Eds.), Phobias: The Psychology of Irrational Fear, An Encyclopedia (14-16). Santa Barbara, CA: Greenwood.
  • Raber, J., Arzy, S., Bertoulus Boulanger J., Depue, B., Haas, H., Kangas, M. Kenzinger, E., Lowry, C., Marusak, H.A., Minnier, J., Mouly, A.M., Muhlberger, A., Norrholm, S., Peltonen, K., Pinna, G., Rabinak, C.A., Shiban, Y., Soreq, H., van der Kooij, M., Weingast, L., Yamashita, P., & Boutros, S. (in press). Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans. Neuroscience & Biobehavioral Reviews
  • Gellci, K., Marusak, H.A., Peters, C., Elrahal, F., Iadipaolo, A., & Rabinak, C.A. (2019). Community and household-level socioeconomic disadvantage and anterior insula-based functional organization in children and adolescents. NeuroImage, 184, 729-740.
  • Marusak, H.A., Iadipalo, A.S., Paulisin, S., Harper, F.W., Taub, J.W., Dulay, K., Elrahal, F., Peters, C., Sala-Hamrick, K., Crespo, L.M., & Rabinak, C.A. (2019). Emotion-related brain organization and behavioral responses to socioemotional stimuli in pediatric cancer survivors with posttraumatic stress symptoms. Pediatric Blood Cancers, 66(1), e27470.
  • Marusak, H.A., Peters, C.A, Hehr, A., Elrahal, F., & Rabinak, C.A. (2018). Poor between-session recall of extinction learning and hippocampal activation and connectivity in children. Neurobiology of Learning & Memory, 156, 86-95.
  • Rabinak, C.A., Peters, C., Marusak, H.A., Ghosh, S., & Phan, Luan K. (2018). Effects of acute Δ9-tetrahydrocannabinol on post-extinction resting-state dynamics within fear-extinction neural circuitry. Neuropharmacology, 143, 289-298.
  • Marusak, H.A., Thomason, M.E., Sala-Hamrick, K., Crespo, L., & Rabinak, C.A. (2018). What’s parenting got to do with it: emotional autonomy and neural processing of emotional conflict in children and adolescents. Developmental Science, 21(4), e12605.
  • Iadipaolo, A.S., Marusak, H.A., Paulisin, S.M., Sala-Hamrick, K., Crespo, L.M., Elrahal, F., Peters, C., Brown, S. & Rabinak, C.A. (2018). Distinct neural correlates of trait resilience within core neurocognitive networks in at-risk children and adolescents. NeuroImage: Clinical, 20, 24-34.
  • Marusak, H.A., Iadipaolo, A.S., Harper, F., Elrahal, F.W., Taub, J.W., Goldberg, E., & Rabinak, C.A. (2018). Neurodevelopmental consequences of pediatric cancer and its treatment: applying an early adversity framework to understanding cognitive, behavioral, and emotional outcomes. Neuropsychology Review, 28(2), 123-1275.
  • Marshall, N.A., Marusak, H.A., Sala-Hamrick, K.J., Crespo, L.M., Rabinak, C.A., & Thomason, M.E. (2018). Socioeconomic disadvantage and altered corticostriatal circuitry in urban youth. Human Brain Mapping, 39(3), 1982-1994.
  • MacNamara, A., Rabinak, C.A., Kennedy, A.E., & Phan, K.L. (2018). Convergence of fMRI and ERP measures of emotional face processing in combat-exposed U.S. Military Veterans. Psychophysiology, 55(2).
  • Marusak, H.A., Elrahal, F., Peters, C.A., Kundu, P., Lombardo, M.V., Calhoun, V.D., Goldberg, E.K., Cohen, C., Taub, J.W., & Rabinak, C.A. (2018). Mindfulness and dynamic functional neural connectivity in children and adolescents. Behavioural Brain Research, 15, 211-218.
  • Marusak, H.A., Peters, C.A., Hehr, A., Elrahal, F., & Rabinak, C.A. (2017). A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality. Scientific Reports, 7(1), 16840.
  • Iadipaolo, A.S., Marusak, H.A., Sala-Hamrick, K., Crespo, L., Thomason, M.E., & Rabinak, C.A. (2017). Behavioral activation sensitivity and default mode network-subgenual cingulate cortex connectivity in youth. Behavioural Brain Research, 333, 135-141.
  • Fitzgerald, J.M., MacNamara, A., Kennedy, A.E., Rabinak, C.A., Rauch, S.A.M., Liberzon, I., & Phan, K.L. (2017). Individual differences in cognitive reappraisal use and emotion regulatory brain function in combat-exposed veterans with and without PTSD. Depression & Anxiety, 34(1), 79-88.
  • Rabinak, C.A., Mori, S.M., Lyons, M., Milad, M.R., & Phan, K.L. (2017). Acquisition of CS-US contingencies during Pavlovian fear conditioning and extinction in social anxiety disorder and posttraumatic stress disorder. Journal of Affective Disorders, 207, 76-85.
  • Marusak, H.A., Hatfield, J.R.B., Thomason, M.E., & Rabinak, C.A. (2017). Reduced ventral tegmental area-hippocampal connectivity in children and adolescents exposed to early threat. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(2), 130-137.
  • Marusak, H.A., Zundel, C., Brown, S., Rabinak, C.A., & Thomason, M.E. (2017). Convergent behavioral and corticolimbic connectivity evidence of a negativity bias in children and adolescents. Social, Cognitive, & Affective Neuroscience, 12(4), 517-525.
  • Marusak, H.A., Thomason, M.E., Peters, C., Zundel, C., Li, A., Elrahal, F., & Rabinak, C.A. (2016). You say “prefrontal cortex” and I say “anterior cingulate”: Meta-analysis of spatial overlap in amygdala to prefrontal connectivity and internalizing symptomology. Translational Psychiatry, 6(11), e944.
  • Gorka, S.M., MacNamara, A., Aase, D.M., Proescher, E., Greenstein, J.E., Walters, R., Passi, H., Babione, J.M., Levy, D.M., Kennedy, A.E., DiGangi, J.A., Rabinak, C.A., Schroth, C., Afshar, K., Fitzgerald, J., Hajcak, G., & Phan, K.L. (2016). Impact of alcohol use disorder comorbidity on defensive reactivity to errors in Veterans with post-traumatic stress disorder. Psychology of Addictive Behaviors, 30(7), 733-742.
  • Fitzgerald, J.M., MacNamara, A., DiGangi, J.A., Kennedy, A.E., Rabinak, C.A., Patwell, R.S., Greenstein, J.E., Proescher, E., Rauch, S.A.M., Hajcak, G., & Phan, K.L. (2016). An electrocortical investigation of voluntary emotion regulation in combat-related posttraumatic stress disorder. Psychiatry Research: Neuroimaging, 249, 113-121.
  • DiGangi, J.A., Tadayyon, A., Fitzgerald, D.A., Rabinak, C.A., Kennedy, A., Klumpp, H., Rauch, S.A., & Phan, K.L. (2016). Reduced default mode network connectivity following combat trauma. Neuroscience Letters, 615, 37-43.
  • Gorka, S.M. Lyons, M., Mori, S., Angstadt, M., & Phan, K.L., & Rabinak, C.A. (2016). Cannabinoid modulation of frontolimbic activation and connectivity during volitional regulation of negative affect. Neuropsychopharmacology, 41, 1888-1896.
  • MacNamara, A., Rabinak, C.A., Kennedy, A.E., Fitzgerald, D.A., Liberzon, I., Stein, M.B., & Phan, K.L. (2016). Emotion regulatory brain function and SSRI treatment in PTSD: Neural correlates and predictors of change. Neuropsychopharmacology, 41(2), 611-618.
  • MacNamara, A., Rabinak, C.A., Fitzgerald, D.A., Zhou, X.J., Shankman, S.A., Milad, M.R., & Phan, K.L. (2015). Neural correlates of individual differences in fear learning. Behavioural Brain Research, 287, 34-41.
  • Mori S., & Rabinak C.A. (2015). Regulating negative affect: a neurophysiological investigation of self-generated and externally-provided reappraisal. Biological Psychiatry, 77, 50S.
  • MacNamara, A., Rabinak, C.A., Kennedy, A.E., Fitzgerald, D.A., Liberzon, I., Stein, M.B., & Phan, K.L. (2015). Emotion regulatory brain function and SSRI treatment in PTSD: Neural correlates and predictors of change. Biological Psychiatry, 77, 233S.
  • Gorka, S.M., Rabinak, C.A., Milad, M.R., Liberzon, I., Maren, S., Phan, K.L. (2015). Effects Δ9-tetrahydrocannabinol (THC) on brain and behavior during fear extinction learning in humans: A combined psychophysiological-fMRI study. Neuropsychopharmacology, 40, S446.
  • Fitzgerald, J.M., MacNamara, A., Kennedy, A.E., Rabinak, C.A., Rauch, S.A.M., Liberzon, I, Phan, K.L. (2016). Individual tendencies to use cognitive reappraisal and emotional regulatory brain function in combat-exposed Veterans with and without PTSD. Biological Psychiatry, 79, 48S-49S.
  • Marusak, H.A., Hehr, A., Peters, C.A., & Rabinak, C.A. (2017). Fear conditioning and extinction in children: new insights into contextual modulation and approach/avoidance behavioural tendencies in virtual reality. Biological Psychiatry, 81(10), S326-S327.
  • Rabinak, C.A., Peters, C., Silverstein, B., Marusak, H.A., Gorka, S., & Phan, K.L. (2017). Effects of acute Δ9-tetrahydrocannabinol on resting-state functional connectivity in fear-related neural circuitry. Biological Psychiatry, 81(10), S327.
  • Rabinak, C.A., Peters, C., Elrahal, F., Milad, M., Rauch, S., Phan, K.L., & Greenwald, M. (2017). Cannabinoid facilitation of fear extinction in posttraumatic stress disorder. Neuropsychopharmacology, 42, S339.
  • Rabinak, C.A., Peters, C., Elrahal, F., Milad, M., Rauch, S., Phan, K.L., & Greenwald (2018). Cannabinoid facilitation of fear extinction in posttraumatic stress disorder. Biological Psychiatry, 83(9), S21.
  • Morgan, S., Marusak, H.A., Elrahal, F., Peters, C., Iadipaolo, A.S., Burghardt, K., & Rabinak, C.A. (2018). Effects of PACAP receptor gene polymorphism on limbic-based brain functional organization in youth. Biological Psychiatry, 83(9), S132.
  • Marusak, H.A., Peters, C., Elrahal, F., Burghardt, K., & Rabinak, C.A. (2018). Effects of genetic variation in endocannabinoid signaling on fear-extinction neural circuitry in children and adolescents. Biological Psychiatry, 83(9), S145.
  • Brahimi, X., Marusak, H.A., & Rabinak, C.A. (2018). Age-related changes in reversal learning and medial temporal lobe circuitry in children. Biological Psychiatry, 83(9), S254-S255.
  • Hehr, A., Marusak, H.A., Huntley, E.D., & Rabinak, C.A. (2018). Shorter sleep duration is associated with lower frontolimbic connectivity in school-age children and adolescents. Biological Psychiatry, 83(9), S259-S260.
  • Hammoud, M., Gorka, S., Rabinak, C.A., Liberzon, I., Maren, S., Phan, K.L. & Milad, M. (2018). Influence of Δ9-tetrahydrocannabinol (THC) on fear extinction learning and spontaneous recovery. Biological Psychiatry, 83(9), S348.
  • Sharif, L., Silverstein, B., Marshall, N., Marusak, H.A., Peters, C., Elrahal, F., & Rabinak, C.A. (2018). Lower trust scores of ambiguous facial expressions associated with increased electrocortical activity. Biological Psychiatry, 83(9), S416.

 

Laboratory Web Site

Translational Neuropsychopharmacology Lab