Kyle Jon Burghardt Pharm.D.

Kyle Jon Burghardt Pharm.D.

Title

Associate Professor

Department

Pharmacy Practice

Office Location

4154

Phone

313-577-3132

Email

kburg@wayne.edu

Kyle Jon Burghardt Pharm.D.

Degrees and Certifications

Degrees
  • 2011-2014 - Post-Doctoral Research Fellow, Pharmacogenomics Lab, University of Michigan College of Pharmacy, Department of Clinical, Social and Administrative Sciences
  • 2011 - University of Michigan, College of Pharmacy, Ann Arbor, Doctorate of Pharmacy with Distinction
  • 2005-2007 - University of Michigan, College of LS&A, Pre-Pharmacy/Biochemistry
  • 2004-2005 - University of California at Santa Cruz, Pre-Pharmacy/Biochemistry
Certifications
  • 2019 - Certificate in Clinical Research Conduct & Management, University of California Berkeley Ext.
  • 2014 - American College of Clinical Pharmacy Focused Investigator Training Program
  • 2013 - MI Regional Comprehensive Metabolomics Resource Cores Summer Metabolomics Workshop
  • 2012 - Institute of General Medical Sciences 2nd Annual Short Course on Statistical, Genetics & Genomics
  • 2012 - Statistical Analysis with R Workshop, Michigan Center for Statistical Consultation and Research

Positions and Employment

  • 2014-Present - Assistant Professor of Pharmacy Practice - Tenure Track, Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences
  • 2011-2014 - Pharmacist at Schmidt and Sons Pharmacy (Tecumseh, MI)
  • 2009 - Research Assistant with the Highland Park Project under the Ginsberg Research Grant, University of Michigan College of Pharmacy, Department of Clinical, Social and Administrative Sciences
  • 2005-2006 - Research Assistant in the Molecular and Behavioral Neuroscience Institute Watson/Akil Lab, University of Michigan School of Medicine

Awards and Honors

  • 2019 - Original Research Award Winner for College of Psychiatric and Neurologic Pharmacist Association
  • 2017 - American College of Clinical Pharmacy Poster Accepted for CE presentation
  • 2016 - Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences College Research Day Poster Award (Mentor to Brittany Lines)
  • 2016 - Undergraduate Research Opportunity Program Grant (Mentor to Nadeen Mansour)
  • 2016 - American College of Clinical Pharmacy New Investigator Award Nomination
  • 2015 - College of Psychiatric and Neurologic Pharmacist Original Research Award
  • 2014 - American Society of Clinical Psychopharmacology (ACSP) Annual Meeting - New Investigator Award recipient
  • 2014 - Poster Award Finalist at the Schizophrenia International Research Society 2014 Meeting
  • 2012 - Travel Fellowship Award for National Institute of General Medical Sciences 2nd Annual Short Course on Statistical Genetics and Genomics
  • 2011 - Doctor of Pharmacy: Community Service Award
  • 2009-2010 - Gertrude and George Huebner Scholarship
  • 2010 - R.A. Deno Award for Significant Improvement in Scholarship

Professional Memberships

  • 2014-Present - American Association of Colleges of Pharmacy
  • 2011-Present - American College of Clinical Pharmacy
  • 2009-Present - College of Psychiatric and Neurologic Pharmacists
  • 2017 - American College of Clinical Pharmacy Grant Reviewer
  • 2012-2015 - College of Psychiatric and Neurologic Pharmacists Student Committee; Member with appointment to “Student Services” subcommittee
  • 2012-2014 - Member of the National Network of Depression Centers (NNDC) Biomarker Taskforce

Areas of Expertise

  • Pharmacoepigenetics
  • Metabolomics
  • Lipidomics
  • Antipsychotics
  • Insulin resistance

Primary Research Interest

Ongoing

  • NIH K23 Patient-Oriented Career Development Award
    Funding IC: NIDDK - K23DK118199
    “Acutely Induced Insulin Resistance by Antipsychotic Medication in Healthy Volunteers: Impact of Skeletal Muscle Epigenomic and Proteomic Mechanisms”
    Role: PI (75%)
  • American Association of Colleges of Pharmacy
    Science of Teaching and Learning Grant
    “Effects of Hands-On Personalized Genetic Testing in Pharmacogenetics Education”
    Role: Primary Investigator (5%)
  • Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences Faculty Research Award Program (FRAP) Collaborative Grant
    “The Role of Transposable Elements in Neurotoxic Effects of Chronic Methamphetamine”
    Role: Co-Primary Investigator
  • National Institutes of Health Loan Repayment Program for Extramural Clinical Research
    Funding IC: National Institute of Diabetes Digestive and Kidney Diseases (NIDDK)
    “Mechanisms of antipsychotic-induced insulin resistance in the skeletal muscle”
    NIH - L30 DK110823
    Role: Primary Investigator

Completed

  • Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences Faculty Research Award Program (FRAP) Collaborative Grant
    “Insulin Resistance Induced by Antipsychotic Medication in the Absence of Obesity: Impact of Skeletal Muscle Protein Kinase-based Mechanisms”
    Role: Primary Investigator (15%)
  • Brain & Behavior Research Foundation
    NARSAD Young Investigator Grant
    “Effects of FAAH Genotype on Fear-Related Brain Activation during Fear Extinction”
    Role: Co-Investigator (5%)
  • Michigan Diabetes Research Center (MDRC)
    P30 Pilot/Feasibility Grant
    “Insulin Resistance Induced by Antipsychotic Medication in the Absence of Weight Gain: Impact of Skeletal Muscle Epigenetic and Protein Mechanisms”
    NIH Grant 2P30-DK020572
    Role: Primary Investigator
  • American College of Clinical Pharmacy
    Futures Research Junior Investigator Grant
    “Insulin Resistance Induced by Antipsychotic Medication in the Absence of Obesity: Impact of DNA Methylation and Lipids in the Skeletal Muscle”
    Role: Primary Investigator
  • Wayne State University Office of the Vice President for Research.
    Research Mentors Program for New Faculty
    PIs: Yi and Burghardt
  • NIH: NIMH
    Sex as a Biological Variable Supplement
    “The Role of Sex in the Epigenetics of Antipsychotic-induced Metabolic Syndrome”
    PI: Ellingrod
    NIH R01 MH082784 S1
    Role: Co-I.
    Facilitate all sample preparation, analyses and data presentation. Publish results.

Recent Publications

NCBI

ORCiD

  • Burghardt KJ*, Howlett BH, Khoury A., Fern SM, Burghardt PR. Three Commonly Utilized Scholarly Databases and a Social Network Site Provide Different, but Related, Metrics of Pharmacy Faculty Publication. Publications 2020, 8(2), 18.
  • Burghardt KJ*, Khoury A, Msallaty Z, Yi Z, Seyoum B. Antipsychotic Medications and DNA Methylation in Schizophrenia and Bipolar Disorder: A Systematic Review. Pharmacotherapy. Accepted 1/24/2020.
  • Burghardt KJ*, Howlett BH, Fern SM, Burghardt PR. A Bibliometric Analysis of the Top 50 NIH-Funded Colleges of Pharmacy Using Two Databases. Research in Social and Administrative Pharmacy. 2019 Oct 9. pii: S1551-7411(19)30677-1.
  • Burghardt KJ*, Howlett BH, Sanders E, Dass SE, Msallaty Z, Mallisho A, Seyoum B, Yi Z. Skeletal Muscle DNA Methylation Modifications and Psychopharmacologic Treatment in Bipolar Disorder. European Neuropsychopharmacology. 2019 Oct 18. pii: S0924-977X(19)31700-6.
  • Kraal, AZ*, Moll AC, Arvanitis NR, Ward KM, Dougherty RJ, Grove TB, Burghardt KJ, Ellingrod VL. Metabolic Syndrome is Negatively Associated with Cognition among Endothelial Nitric Oxide Synthase (eNOS)-786C carriers in Schizophrenia-Spectrum Disorders. Journal of Psychiatric Research. 2019 Oct;117:142-147.
  • James R. Bagley, Kyle J. Burghardt, Ryan McManus, Irene S. Tobias, Bradley Howlett, Pablo B. Costa, Jared W. Coburn, Jose A. Arevalo, Moh H. Malek, and Andrew J. Galpin*. Epigenetic Responses To Acute Resistance Exercise In Trained Vs. Sedentary Men. Journal of Strength and Conditioning Research. In Press.
  • Burghardt KJ, Ward KM, Sanders E, Howlett BH, Seyoum B, Yi Z. Atypical Antipsychotics and the Human Skeletal Muscle Lipidome. Metabolites. 2018 Oct 13;8(4).
  • Bacon OM, Burghardt DR, Burghardt KJ. Management of pain in a patient taking naltrexone and needing an outpatient procedure. Current Psychiatry. Current Psychiatry. 2018 September;17(9):46-48.
  • Burghardt KJ, Goodrich JM, Line BN, EllingrodVL. The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia. Int J Genomics. Volume 2018 (2018), Article ID 8076397, 12 pages.
  • Burghardt KJ, Seyoum B, Dass SE, Sandera E, Mallisho A, Yi Z. Association of Protein Kinase B (AKT) DNA Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Patients with Bipolar Disorder. Pharmacotherapy. 2018 Apr;38(4):428-435.
  • Burghardt KJ, Seyoum B, Mallisho A, Burghardt PR, Kowluru RA, Yi Z. Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Apr 20;83:55-63.
  • Burghardt KJ, Jaber LA. Haptoglobin Gene Polymorphisms and Diabetes Risk in the Arab-American Population. Submitted to Biomarkers in Medicine. Biomarkers in Medicine. Biomark Med. 2017 Nov;11(11):937-945.
  • Moszczynska A, Burghardt KJ, Yu D. Neurotoxic Doses of Chronic Methamphetamine Trigger Retrotransposition of Identifier Element in Rat Dorsal Dentate Gyrus. Genes (Basel). Genes (Basel). 2017 Mar 6;8(3)
  • Grove TBa, Burghardt KJ, Kraal AZ, Dougherty RJ, Taylor SF, Ellingrod VL. Oxytocin Receptor (OXTR) Methylation and Cognition in Psychotic Disorders. Mol Neuropsychiatry. 2016 Oct;2(3):151-160. (adenotes equal effort)
  • Burghardt KJ, Goodrich JM, Dolinoy DC, EllingrodVL. Gene-specific DNA methylation may mediate atypical antipsychotic-induced insulin resistance. Bipolar Disord. 2016 Aug;18(5):423-32.
  • Gamal RS, Gardner KN, Burghardt KJ Pharmacogenomics Resources for the Psychiatric Practitioner. Current Psychiatry. Current Psychiatry. 2016 Sep;15(9):93-94.
  • Parker D, Sanders EJ, Burghardt KJ. Pharmacogenetics of Antiepileptic Drugs: A Brief Review. Mental Health Clinician. 2016 Jan; 6(1): 28-34.
  • Ellingrod VL, Grove TB, Burghardt KJ, Taylor SF, Dalack G. The effect of folate supplementation and genotype on cardiovascular and epigenetic measures in schizophrenia subjects. Npj Schizophrenia. 2015 November; 1:15046.
  • Burghardt KJ, Thomas ST, Tutag-Lehr V. Off-label use of duloxetine for pediatric neuropathic pain. 2015 November; 5(6):277-283.
  • Burghardt KJ, Evans SJ, Wiese KM, Ellingrod VL. An Untargeted Metabolomics Analysis of Antipsychotic Use in Bipolar Disorder. Clinical and translational science. 2015; 8(5):432-40.
  • Burghardt KJ, Goodrich JM, Dolinoy DC, EllingrodVL. DNA methylation, insulin resistance and second generation antipsychotics (SGA) in bipolar disorder. Epigenomics. 2015; 7(3):343-52.
  • Bly MJ, Taylor SF, Dalack G, Pop-Busui R, Burghardt KJ, Evans SJ, McInnis MI, Grove TB, Brook RD, Zöllner SK, Ellingrod VL. Metabolic syndrome in bipolar disorder and schizophrenia: dietary and lifestyle factors compared to the general population. Bipolar Disord. 2014 May;16(3):277-88.
  • Burghardt K, Grove T, Ellingrod V. Endothelial nitric oxide synthetase genetic variants, metabolic syndrome and endothelial function in schizophrenia. J Psychopharmacol. 2014 Apr;28(4):349-56
  • Bostwick JR, Burghardt KJ, Choe HM, Deneke E, Fluent T. Opportunities to partner with clinical pharmacists in ambulatory psychiatry. Current Psychiatry 2014 July;13(7):23-29.