Kyle Jon Burghardt Pharm.D.

Kyle Jon Burghardt Pharm.D.

Title

Assistant Professor

Department

Pharmacy Practice

Office Location

4154

Phone

313-577-3132

Email

kburg@wayne.edu

Kyle Jon Burghardt Pharm.D.

Degrees and Certifications

  • Certificate in Clinical Research Conduct and Management, University of California Berkeley Extension, April 2019
  • American College of Clinical Pharmacy Focused Investigator Training Program, July 2014
  • Post-Doctoral Research Fellow, Pharmacogenomics Lab, University of Michigan College of Pharmacy, Department of Clinical, Social and Administrative Sciences, June 2011-May 2014
  • Michigan Regional Comprehensive Metabolomics Resource Cores Summer Metabolomics Workshop, June 2013
  • National Institute of General Medical Sciences 2nd Annual Short Course on Statistical, Genetics and Genomics, July 9, 2012
  • Statistical Analysis with R Workshop, Michigan Center for Statistical Consultation and Research, March 2012
  • University of Michigan, College of Pharmacy, Ann Arbor, Doctorate of Pharmacy with Distinction, May 2011
  • University of Michigan, College of LS&A, Pre-Pharmacy/Biochemistry, Sept. 2005-April 2007
  • University of California at Santa Cruz, Pre-Pharmacy/Biochemistry, Sept. 2004-June 2005

Positions and Employment

  • Assistant Professor of Pharmacy Practice - Tenure Track, Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences, Aug. 2014-present
  • Pharmacist at Schmidt and Sons Pharmacy (Tecumseh, MI), Aug. 2011-Aug. 2014
  • Research Assistant with the Highland Park Project under the Ginsberg Research Grant, University of Michigan College of Pharmacy, Department of Clinical, Social and Administrative Sciences, July 2009-Oct. 2009
  • Research Assistant in the Molecular and Behavioral Neuroscience Institute Watson/Akil Lab, University of Michigan School of Medicine, Sept. 2005-Sept. 2006

Awards and Honors

  • Wayne State College of Pharmacy Research Day Best Poster (role: mentor to student), Oct. 2016
  • Undergraduate Research Opportunity Award (role: mentor to student), June 2016
  • Original Research Award 2015 - College of Neurologic and Psychiatric Pharmacists, May 2015
  • American Society of Clinical Psychopharmacology (ACSP) Annual Meeting - New Investigator Award Recipient, June 2014
  • Poster Award Finalist at the Schizophrenia International Research Society 2014 Meeting, April 2014
  • Travel Fellowship Award for National Institute of General Medical Sciences 2nd Annual Short Course on Statistical Genetics and Genomics, June 2012
  • Doctor of Pharmacy: Community Service Award, June 4, 2011
  • Gertrude and George Huebner Scholarship, Sept. 2009 and 2010
  • R.A. Deno Award for Significant Improvement in Scholarship, March 2010

Professional Memberships

  • College of Psychiatric and Neurologic Pharmacists, 2009-present
  • American College of Clinical Pharmacy, 2011-present
  • Member of the National Network of Depression Centers (NNDC) Biomarker Taskforce, 2012-2014
  • College of Psychiatric and Neurologic Pharmacists Student Committee; Member with appointment to “Student Services” subcommittee, 2012-2015
  • American College of Clinical Pharmacy Grant Reviewer, 2017-present

Areas of Expertise

  • Pharmacoepigenetics
  • Metabolomics
  • Lipidomics
  • Antipsychotics
  • Insulin resistance

Primary Research Interest

Ongoing

NIH K23 Patient-Oriented Career Development Award Funding IC: NIDDK - K23DK118199
“Acutely Induced Insulin Resistance by Antipsychotic Medication in Healthy Volunteers: Impact of Skeletal Muscle Epigenomic and Proteomic Mechanisms”
Role: Primary Investigator (75%)
The goal of this work it to analyze epigenomic (Aim 1) and proteomic (Aim 2) underpinnings of antipsychotic-induced insulin resistance.
Period: 8/1/2018 – 7/31/2022

American Association Of Colleges of Pharmacy Science of Teaching and Learning Grant
“Effects of Hands-On Personalized Genetic Testing in Pharmacogenetics Education”
Role: Primary Investigator (5%)
The goal of this work is to evaluate personal genetic testing and hands-on learning effects on pharmacy student knowledge, abilities and attitudes within a pharmacogenetics course.
Period: 6/1/2018-5/30/2019

Brain & Behavior Research Foundation, NARSAD Young Investigator Grant
Title: Effects of FAAH Genotype on Fear-Related Brain Activation during Fear Extinction (PI:Christine Rabinak)
Role: Co-Investigator (5%)
Responsibilities: Performing candidate pharmacogenetics analyses, assisting in interpreting and publishing results.
Goal: Identify the effects of candidate Fatty acid amide hydrolase (FAAH) polymorphisms on brain activation during fear extinction in post-traumatic stress disorder.
Period: 01/15/2017-01/14/2019

Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences Faculty Research Award Program (FRAP) Collaborative Grant
Title: Insulin Resistance Induced by Antipsychotic Medication in the Absence of Obesity: Impact of Skeletal Muscle Protein Kinase-based Mechanisms
Role: Primary Investigator
Responsibilities: Running, interpreting and publishing epigenomic data
Goal: Identify changes in the skeletal muscle epigenome based on insulin sensitivity from a cross-sectional sample of psychiatric subjects currently stable on atypical antipsychotics (utilizing samples banked from studies below).
Period: 3/1/2016 – 2/28/2019

Completed

Michigan Diabetes Research Center (MDRC) P30 Pilot/Feasibility Grant
Title: Insulin Resistance Induced by Antipsychotic Medication in the Absence of Weight Gain: Impact of Skeletal Muscle Epigenetic and Protein Mechanisms
NIH Grant 2P30-DK020572
Role: Primary Investigator
Responsibilities: Directing research, collecting samples, analyzing samples and sharing data through publication and presentations.
Goal: Analyze DNA methylation and overall proteomic changes based on insulin sensitivity from a cross-sectional sample of bipolar subjects
Period: 1/1/2016 – 12/31/2017

American College of Clinical Pharmacy Research Institute Futures Grant Junior Investigator Award
Title: Insulin Resistance Induced by Antipsychotic Medication in the Absence of Obesity: Impact of DNA Methylation and Lipids in the Skeletal Muscle.
Mentors: Dr. Renu Kowluru, Dr. Zhengping Yi
Role: Primary Investigator
Responsibilities: Directing research, collecting samples, analyzing samples and sharing data through publication and presentations.
Goal: Identify differential skeletal muscle gene methylation involved in antipsychotic-induced insulin resistance from a cross-sectional sample of bipolar subjects
Period: 9/15/2015 – 9/14/2017

NIH: Antipsychotic and Folate Pharmacogenetics- Gender Supplement
Principal: Ellingrod
NIH R01 MH082784 S1 (PI: Vicki Ellingrod)
Role: Co-Investigator (10%)
Responsibilities: Assisting in idea development and supplement grant submission, using previously collected samples to prepare DNA for Illumina 450K BeadChip (Epigenome-wide analysis), analyzing data, interpreting and publishing.
Goal: Identify candidate epigenes that may help to explain the increased risk of metabolic syndrome in female patients with schizophrenia
Period: 7/1/14 – 12/30/2015

Pilot Grant From Univeristy of Michigan CTSA
Role: Primary Investigator
Michigan Institute for Clinical and Health (MICHR). Pharmacometabolomics of Bipolar Disorder Treatments.
Project # UL1RR024986
Period: 12/2013-12/2014

Rachel Upjohn Clinical Scholars Award 2012.
Principal: Primary Investigator
University of Michigan Depression Center. The Epigenetics of Atypical Antipsychotic-Associated Metabolic Syndrome in Bipolar Disorder.
Period: 11/2013 – 11/2015

Recent Publications