Steven M. Firestine Ph.D.

Steven M. Firestine Ph.D.



Office Location

EACPHS, Room 3134





Pharmaceutical Sciences


Professor, Department of Pharmaceutical Sciences

Steven M. Firestine Ph.D.

Degrees and Certifications

B.S. Chemistry - University of Michigan, Ann Arbor MI

PhD. Medicinal Chemistry - Purdue University, West Lafayette IN

Postdoc Enzymology - Pennsylvania State University, University Park PA

Positions and Employment

1988-1990 Undergraduate Research Assistant (Dr. James K. Coward), University of Michigan,
Ann Arbor, MI

1990-1995 Graduate Research Assistant (Dr. V. Jo Davission), Purdue University , West Lafayette, IN

1996-2000 Postdoctoral Fellow (Dr. Stephen J. Benkovic), The Pennsylvania State University,
University Park, PA

2000-2005 Assistant Professor of Medicinal Chemistry, Duquesne University Mylan School of Pharmacy, Pittsburgh PA

2005-2010 Assistant Professor of Pharmaceutical Sciences, Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI

2010-2016 Associate Professor of Pharmaceutical Sciences, Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI

2016-present Professor of Pharmaceutical Sciences,  Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI 

Awards and Honors

1989 Gomberg Summer Research Fellowship, University of Michigan

1990 Merck Award, University of Michigan

1992-1993 NIH Predoctoral Training grant, Purdue University

1994-1995 American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship, Purdue University

1995 Jenkins/Knevel Award for Outstanding Graduate Research, Purdue University

1996-1999 Damon Runyon-Walter Winchell Fellowship, Penn State

1999 ASBMB Travel Award, Penn State

2005 Outstanding Young Investigator, Duquesne University

2012 Research Recognition Award, Outstanding Achievement in Basic Science Research, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University

2015 Outstanding Graduate Mentor, Wayne State University

2016 Faculty Recognition Award in Pharmaceutical Sciences, Class of 2016, Wayne State University

Areas of Expertise

 Medicinal Chemistry; Biochemistry; Molecular Biology; Enzymology; Computational Chemistry; Organic Chemistry

Primary Research Interest

Antiinfective Drug Discovery; Organic Chemistry; Biochemistry; Chemical Biology

Recent Publications

  1. Rowe H.M., Hanson B.R., Runft D.L., Lin Q., Firestine S.M. and Neely M.N.* Modification of the CpsA Protein Reveals a Role in Alteration of the Streptococcus agalactiae Cell Envelope. Infect Immun., 1497-506, 2015.
  2. Kochanek, S., Clymer, T., Pakkala, V., Hebert, S., Reeping, K., Firestine, S.M.*, and Evanseck, J.D.*, Intramolecular Charge-Assisted Hydrogen Bond Strength in Pseudo-Chair Carboxyphosphate. J. Phys. Chem. B., 1184-91, 2015.
  3. Dewal, M. B. and Firestine, S. M.* Site-Directed Mutagenesis of Catalytic Residues in N5-Carboxyaminoimidazole Ribonucleotide Synthetase. Biochemistry, 52, 6559-6567, 2013.
  4. Islam, M.S. and Firestine, S.M.* Synthesis of substituted pyridyl-pyrimidines as potential protein-protein interaction inhibitors. J. Heterocycl. Chem., 50, 1043-1048, 2013.
  5. Li J., Zhu Y., Hazeldine S.T., Firestine S.M. and Oupický D*. Cyclam-Based Polymeric Copper Chelators for Gene Delivery and Potential PET Imaging. Biomacromolecules, 13, 3220-3227, 2012.
  6. Dewal, M.B., Wani, A.S., Vidaillac, C., Oupicky, D., Rybak, M.J. and Firestine, S.M.* Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents. Eur. J. Med. Chem., 51, 145-53, 2012.
  7. Fawaz, M.V., Topper, M.E. and Firestine, S.M.* The ATP-grasp enzymes. Bioorg. Chem., 39, 185-191, 2011.
  8. Vooturi, S.K., Dewal, M.B. and Firestine, S.M.* Examination of a synthetic benzophenone membrane-targeted antibiotic. Org. Biomol. Chem., 9, 6367-6372, 2011.
  9. Dewal, M.B. and Firestine, S.M.* Non-peptidic α-helical mimetics as protein-protein interaction inhibitors. Curr. Med. Chem., 18, 2420-2428, 2011.
  10. Vooturi, S.K. and Firestine, S.M. Synthetic Membrane-Targeted Antibiotics. Curr. Med. Chem.,. 2010, 17, 2292-2300.
  11. Thoden, J.B., Holden, H.M., Paritala, H., and Firestine, S.M. Structure and Site-Directed Mutagenesis ofAspergillus clavatus N5-Carboxylaminoimidazole Ribonucleotide Synthetase. Biochemistry, 2010, 49, 752-60.
  12. Paritala, H. and Firestine, S.M. Characterization of insulin ILPR sequences for their ability to adopt a G-quadruplex structure. Nucleosides Nucleotides Nucleic Acids, 2010, 29, 81-90.
  13. Vooturi, S.K. and Firestine, S.M.* Solution-Phase Parallel Synthesis of Novel Membrane-Targeted Antibiotics. J. Comb. Chem., 2010, 12, 151-160.

Publications: 43

Poster and Oral Presentations: Over 100 presentations.

Research website