Henry Claude Wormser Ph.D.

Henry Claude Wormser Ph.D.

Title

Professor Emeritus

Department

Pharmaceutical Sciences

Office Location

EACPHS, Room 3116

Phone

313-993-4244

Email

henryw@wayne.edu

Henry Claude Wormser Ph.D.

Degrees and Certifications

  • Ph.D. Degree, Medicinal Chemistry, University of Wisconsin, Madison, WI, 1965
  • M.S. Degree, Pharmaceutical Chemistry, Temple University, Philadelphia, PA, 1961
  • B.S. Degree, Pharmacy, Temple University, Philadelphia, PA, 1959

Positions and Employment

Wayne State University, Detroit, MI 1965 - present
Professor of Medicinal Chemistry 1976 - present
Associate Professor of Medicinal Chemistry 1968-1976
Assistant Professor of Medicinal Chemistry 1965-1976

Wisconsin University, Madison, WI 1964 - 1965
Instructor of Pharmacognosy
Research assistant 1961 - 1964

Temple University School of Pharmacy, Philadelphia, PA
Graduate assistant in undergraduate chemistry laboratory 1959 - 1961

Awards and Honors

  • Induction into Rho Chi Honor Society, 1958
  • Teacher of the Year 1980, 1983, 1985

Areas of Expertise

Synthesis of potentially active medicinals and natural products

Primary Research Interest

  • Synthesis of substituted indole-3-caboxamide compounds as local anesthetics
  • Synthesis of natural products (Aristolochic acid and derivatives)
  • Photochemical synthesis of phenanthrenes
  • Synthesis of biotin analogs for biochemical enzymatic studies
  • Synthesis of anthracycline derivatives as anticancer drugs
  • Synthesis of novel heterocyclic ring systems as potential drugs

Recent Publications

  1. H. C. Wormser, S. Elkin, "Synthesis of Pharmacology of Several Substituted Indole-3-carboxamide Derivatives", J. Pharm. Sci., 50: 976, (1961).
  2. S. Morris Kupchan and Henry C. Wormser, "Tumor Inhibitors. IX. Synthesis of 10-Nitro-1-phenanthroic Acid", J. Org. Chem., 30: 3933 (1965).
  3. S. Morris Kupchan and Henry C. Wormser, "Tumor Inhibitors. X. Photochemical Synthesis of Phenanthrenes. Synthesis of Aristolochic Acid and Related Compounds", J. Org. Chem., 30: 3792 (1965).
  4. Henry C. Wormser, "Synthetic Approaches to the Pyrrolo[3,4-d]Imidazole Nucleus", J. Pharm. Sci., 58: 1038 (1969).
  5. Henry C. Wormser, "Synthesis of Azabiotin Analogs as Potential Cofactors for Biotin-Dependent Enzymes", J. Pharm. Sci., 59: 1732 (1970).
  6. Edward J. Randinitis, Martin Barr, Henry C. Wormser and Janardan B. Nagwekar, "Kinetics of Urinary Secretion of D(-)-Mandelic Acid and its Homologs. I. Mutual Inhibitory Effects of D(-)-Mandelic Acid and its Certain Homologs on Their Renal Tubular Secretion in Rats", J. Pharm. Sci., 59: 806 (1970).
  7. Henry C. Wormser, Santhong Israsena, Meredith S. Meiling, Craig Williams and D. Perlman, "Synthesis and Growth-Promoting Activity of dl-cis-Hexahydro-4-(4-carboxybutyl)-2-cyclopentimida-zolone: Carbobiotin", J. Pharm. Sci., 61, 1168 (1972).
  8. Henry C. Wormser and Wen-Hsiung Chiu, "Synthetic Study in the Pyrrolo[2,3-d]imidazole System", J. Heterocyclic Chem., 12: 595 (1975).
  9. Henry C. Wormser and Hanley N. Abramson, "Synthesis of dl-4 -(4-carboxybutyl)-5-carbethoxy-cis-hexahydropyrrolo [3,4-d]imidazol-2-one: N-Carbethoxyazabiotin", J. Pharm. Sci., 64: 1514 (1975).
  10. H. C. Wormser and Hanley N. Abramson, "Synthesis of dl-4-(2-carboxyethyl)-cis-hexahydropyrrolo [3,4-d]imidazol-2-one: Bisnorazabiotin", J. Pharm. Sci., 64: 1882 (1975).
  11. Henry C. Wormser and Hanley N. Abramson, "Air Oxidation of Tetra-substituted 3-Pyrrolines to their Corresponding Pyrroles in the Solid State", J. Heterocyclic Chem., 13: 113, (1975).
  12. Henry C. Wormser and Hanley N. Abramson, "A Study of the Fragmentation of 3-Oximino-4-chromanone", J. Pharm. Sci. 65: 397 (1976).
  13. Henry C. Wormser and Hanley N. Abramson, "The Total Synthesis of dl-3a,4,6a-cis-4-(4-carboxybutyl)hexahydropyrrolo[3,4-d]-imidazol-2-one Hydrochloride: (dl-Azabiotin Hydrochloride)", J. Pharm. Sci. 66: 1208 (1977).
  14. M. D. Glick, Henry C. Wormser and Hanley N. Abramson, "Crystal and Molecular Structure of (+)-Azabiotin Hydrochloride, The Nitrogen Analog of Biotin", Acta Crystallogr., B33, 1095 (1977).
  15. Hanley N. Abramson and Henry C. Wormser "Synthesis of Nectriapyrone", J. Heterocyclic Chem., 18, 363 (1981).
  16. D. L. Vesely, Hanley N. Abramson and Henry C. Wormser, "Biotin Analogs Activate Guanylate Cyclase", Molecular and Cellular Biochemistry, 60: 109 (1984).
  17. Joseph P. Nachtman, E. T. Roginski, Jon W. Banning, Henry C. Wormser, Hanley N. Abramson and T. H. Corbett, "DNA Binding, Cardiac Superoxide Production and Cytotoxicity of Daunomycin Analogs", Research Communications in Chemical Pathology and Pharmacology, 47: 73 (1985).
  18. Hanley N. Abramson, Jon W. Banning, Joseph P. Nachtman, E. T. Roginski, M. Sardessai, Henry C. Wormser, Jender Wu, Ziad Nagia,
  19. R. R. Schroeder and M. M. Bernardo, "Synthesis of Anthraquinonyl Glucosaminosides and Studies on the Influence of Hydroxyl Substitution on Superoxide Generation, DNA Binding, and Antimicrobial Properties," J. Med. Chem., 29: (1986).
  20. Jon W. Banning, Hanley N. Abramson, Henry C. Wormser, Jender Wu and T. H. Corbett, "Relative Cardiotoxicity and Cytotoxicity Anthraquinonlyl Glucosaminosides," Cancer Chemotheraphy and Pharmacol., 19: 207 (1987).
  21. Michael T. Furlong, Hanley N. Abramson, Nnaemeka A. Akamike and Henry C. Wormser, "Approach to Aminated Anthracyclines via an intramolecular Marschalk Reaction", Synthetic Communications, 20: 2691 (1990).
  22. Henry C. Wormser, Manik S. Sardessai, and Hanley N. Abramson, "A Facile Method for Preparing Substituted 1-Aminoanthraquinones",Synthetic Communications, 23(22):3211 (1993).
  23. Manik S. Sardessai, Henry C. Wormser, and Hanley N. Abramson, "Synthesis of Aminated Naphthacenetriones: Precursors to Aminated Anthracyclines" Synthetic Communications, 23(22):3223 (1993).

Invited Review Articles

  1. Henry C. Wormser, "Oral Contraceptives", J. Kansas Pharmacy, 42: No. 11 (1966).
  2. Henry C. Wormser, "O-T-C Poison Ivy and Poison Oak Remedies", J. APhA, 7, No. 2 (1967).
  3. Henry C. Wormser, "Oral Contraceptives", Michigan State Pharmaceutical Association Continuing Education Lectures, Manual for 1966-67, Lansing, MI.
  4. Henry C. Wormser, "Over-the Counter Poison Ivy and Poison Oak Remedies", Cutis, 4, 730 (1968).
  5. Hanley N. Abramson and Henry C. Wormser, "Migraine", The Michigan Pharmacist, Jan., 1972, p. 14.
  6. Hanley Abramson and Henry C. Wormser, "Glaucoma", The Michigan Pharmacist, March, 1972, p. 13.
  7. Hanley N. Abramson and Henry C. Wormser, "Psoriasis", The Michigan Pharmacist, May, 1972, p. 14.
  8. Henry C. Wormser and Hanley N. Abramson, "Bronchial Asthma - Part I", The Michigan Pharmacist, Nov., 1972, p. 23.
  9. Hanley N. Abramson and Henry C. Wormser, "Drugs and Pregnancy - Part II", The Michigan Pharmacist, Nov., 1972, p. 23.
  10. Hanley N. Abramson and Henry C. Wormser, "Drugs and Pregnancy - Part III", The Michigan Pharmacist, May, 1973, p. 24.
  11. Mary Kerins, Lawrence Power and Henry C. Wormser, "A Study of Pharmacist Contributions in an Outpatient Diabetic Clinic", Lippincott's Hospital Pharmacy, 8: 1 (1973).
  12. Henry C. Wormser and Hanley N. Abrams, "Atherosclerosis and Antilipemic Agents", The Apothecary, April, 1974, p. 26.
  13. Henry C. Wormser and Hanley N. Abramson, "A Review of Digitals Therapy", U. S. Pharmacist, 2, 50 (1977).
  14. Henry C. Wormser and Hanley N. Abramson, "Controlling and Treating Pinworm Infestations", U. S. Pharmacist, 4, 61 (1979).
  15. Hanley N. Abramson, Henry C. Wormser and M. Taylor-Wehr, "Therapeutic Uses of Oral Zinc", U. S. Pharmacist, 4, 61 (1979).