Kyle Jon Burghardt Pharm.D.

Kyle Jon Burghardt Pharm.D.

Title

Assistant Professor

Department

Pharmacy Practice

Office Location

4154

Phone

313-577-3132

Email

kburg@wayne.edu

Kyle Jon Burghardt Pharm.D.

Degrees and Certifications

Degrees
  • 2011-2014 - Post-Doctoral Research Fellow, Pharmacogenomics Lab, University of Michigan College of Pharmacy, Department of Clinical, Social and Administrative Sciences
  • 2011 - University of Michigan, College of Pharmacy, Ann Arbor, Doctorate of Pharmacy with Distinction
  • 2005-2007 - University of Michigan, College of LS&A, Pre-Pharmacy/Biochemistry
  • 2004-2005 - University of California at Santa Cruz, Pre-Pharmacy/Biochemistry
Certifications
  • 2019 - Certificate in Clinical Research Conduct & Management, University of California Berkeley Ext.
  • 2014 - American College of Clinical Pharmacy Focused Investigator Training Program
  • 2013 - MI Regional Comprehensive Metabolomics Resource Cores Summer Metabolomics Workshop
  • 2012 - Institute of General Medical Sciences 2nd Annual Short Course on Statistical, Genetics & Genomics
  • 2012 - Statistical Analysis with R Workshop, Michigan Center for Statistical Consultation and Research

Positions and Employment

  • 2014-Present - Assistant Professor of Pharmacy Practice - Tenure Track, Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences
  • 2011-2014 - Pharmacist at Schmidt and Sons Pharmacy (Tecumseh, MI)
  • 2009 - Research Assistant with the Highland Park Project under the Ginsberg Research Grant, University of Michigan College of Pharmacy, Department of Clinical, Social and Administrative Sciences
  • 2005-2006 - Research Assistant in the Molecular and Behavioral Neuroscience Institute Watson/Akil Lab, University of Michigan School of Medicine

Awards and Honors

  • 2019 - Original Research Award Winner for College of Psychiatric and Neurologic Pharmacist Association
  • 2017 - American College of Clinical Pharmacy Poster Accepted for CE presentation
  • 2016 - Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences College Research Day Poster Award (Mentor to Brittany Lines)
  • 2016 - Undergraduate Research Opportunity Program Grant (Mentor to Nadeen Mansour)
  • 2016 - American College of Clinical Pharmacy New Investigator Award Nomination
  • 2015 - College of Psychiatric and Neurologic Pharmacist Original Research Award
  • 2014 - American Society of Clinical Psychopharmacology (ACSP) Annual Meeting - New Investigator Award recipient
  • 2014 - Poster Award Finalist at the Schizophrenia International Research Society 2014 Meeting
  • 2012 - Travel Fellowship Award for National Institute of General Medical Sciences 2nd Annual Short Course on Statistical Genetics and Genomics
  • 2011 - Doctor of Pharmacy: Community Service Award
  • 2009-2010 - Gertrude and George Huebner Scholarship
  • 2010 - R.A. Deno Award for Significant Improvement in Scholarship

Professional Memberships

  • 2014-Present - American Association of Colleges of Pharmacy
  • 2011-Present - American College of Clinical Pharmacy
  • 2009-Present - College of Psychiatric and Neurologic Pharmacists
  • 2017 - American College of Clinical Pharmacy Grant Reviewer
  • 2012-2015 - College of Psychiatric and Neurologic Pharmacists Student Committee; Member with appointment to “Student Services” subcommittee
  • 2012-2014 - Member of the National Network of Depression Centers (NNDC) Biomarker Taskforce

Areas of Expertise

  • Pharmacoepigenetics
  • Metabolomics
  • Lipidomics
  • Antipsychotics
  • Insulin resistance

Primary Research Interest

Ongoing

  • NIH K23 Patient-Oriented Career Development Award
    Funding IC: NIDDK - K23DK118199
    “Acutely Induced Insulin Resistance by Antipsychotic Medication in Healthy Volunteers: Impact of Skeletal Muscle Epigenomic and Proteomic Mechanisms”
    Role: PI (75%)
  • American Association of Colleges of Pharmacy
    Science of Teaching and Learning Grant
    “Effects of Hands-On Personalized Genetic Testing in Pharmacogenetics Education”
    Role: Primary Investigator (5%)
  • Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences Faculty Research Award Program (FRAP) Collaborative Grant
    “The Role of Transposable Elements in Neurotoxic Effects of Chronic Methamphetamine”
    Role: Co-Primary Investigator
  • National Institutes of Health Loan Repayment Program for Extramural Clinical Research
    Funding IC: National Institute of Diabetes Digestive and Kidney Diseases (NIDDK)
    “Mechanisms of antipsychotic-induced insulin resistance in the skeletal muscle”
    NIH - L30 DK110823
    Role: Primary Investigator

Completed

  • Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences Faculty Research Award Program (FRAP) Collaborative Grant
    “Insulin Resistance Induced by Antipsychotic Medication in the Absence of Obesity: Impact of Skeletal Muscle Protein Kinase-based Mechanisms”
    Role: Primary Investigator (15%)
  • Brain & Behavior Research Foundation
    NARSAD Young Investigator Grant
    “Effects of FAAH Genotype on Fear-Related Brain Activation during Fear Extinction”
    Role: Co-Investigator (5%)
  • Michigan Diabetes Research Center (MDRC)
    P30 Pilot/Feasibility Grant
    “Insulin Resistance Induced by Antipsychotic Medication in the Absence of Weight Gain: Impact of Skeletal Muscle Epigenetic and Protein Mechanisms”
    NIH Grant 2P30-DK020572
    Role: Primary Investigator
  • American College of Clinical Pharmacy
    Futures Research Junior Investigator Grant
    “Insulin Resistance Induced by Antipsychotic Medication in the Absence of Obesity: Impact of DNA Methylation and Lipids in the Skeletal Muscle”
    Role: Primary Investigator
  • Wayne State University Office of the Vice President for Research.
    Research Mentors Program for New Faculty
    PIs: Yi and Burghardt
  • NIH: NIMH
    Sex as a Biological Variable Supplement
    “The Role of Sex in the Epigenetics of Antipsychotic-induced Metabolic Syndrome”
    PI: Ellingrod
    NIH R01 MH082784 S1
    Role: Co-I.
    Facilitate all sample preparation, analyses and data presentation. Publish results.

Recent Publications

NCBI

ORCiD

  • James R. Bagley, Kyle J. Burghardt, Ryan McManus, Irene S. Tobias, Bradley Howlett, Pablo B. Costa, Jared W. Coburn, Jose A. Arevalo, Moh H. Malek, and Andrew J. Galpin*. Epigenetic Responses To Acute Resistance Exercise In Trained Vs. Sedentary Men. Journal of Strength and Conditioning Research. In Press.
  • Burghardt KJ, Ward KM, Sanders E, Howlett BH, Seyoum B, Yi Z. Atypical Antipsychotics and the Human Skeletal Muscle Lipidome. Metabolites. 2018 Oct 13;8(4).
  • Bacon OM, Burghardt DR, Burghardt KJ. Management of pain in a patient taking naltrexone and needing an outpatient procedure. Current Psychiatry. Current Psychiatry. 2018 September;17(9):46-48.
  • Burghardt KJ, Goodrich JM, Line BN, EllingrodVL. The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia. Int J Genomics. Volume 2018 (2018), Article ID 8076397, 12 pages.
  • Burghardt KJ, Seyoum B, Dass SE, Sandera E, Mallisho A, Yi Z. Association of Protein Kinase B (AKT) DNA Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Patients with Bipolar Disorder. Pharmacotherapy. 2018 Apr;38(4):428-435.
  • Burghardt KJ, Seyoum B, Mallisho A, Burghardt PR, Kowluru RA, Yi Z. Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Apr 20;83:55-63.
  • Burghardt KJ, Jaber LA. Haptoglobin Gene Polymorphisms and Diabetes Risk in the Arab-American Population. Submitted to Biomarkers in Medicine. Biomarkers in Medicine. Biomark Med. 2017 Nov;11(11):937-945.
  • Moszczynska A, Burghardt KJ, Yu D. Neurotoxic Doses of Chronic Methamphetamine Trigger Retrotransposition of Identifier Element in Rat Dorsal Dentate Gyrus. Genes (Basel). Genes (Basel). 2017 Mar 6;8(3)
  • Grove TBa, Burghardt KJ, Kraal AZ, Dougherty RJ, Taylor SF, Ellingrod VL. Oxytocin Receptor (OXTR) Methylation and Cognition in Psychotic Disorders. Mol Neuropsychiatry. 2016 Oct;2(3):151-160. (adenotes equal effort)
  • Burghardt KJ, Goodrich JM, Dolinoy DC, EllingrodVL. Gene-specific DNA methylation may mediate atypical antipsychotic-induced insulin resistance. Bipolar Disord. 2016 Aug;18(5):423-32.
  • Gamal RS, Gardner KN, Burghardt KJ Pharmacogenomics Resources for the Psychiatric Practitioner. Current Psychiatry. Current Psychiatry. 2016 Sep;15(9):93-94.
  • Parker D, Sanders EJ, Burghardt KJ. Pharmacogenetics of Antiepileptic Drugs: A Brief Review. Mental Health Clinician. 2016 Jan; 6(1): 28-34.
  • Ellingrod VL, Grove TB, Burghardt KJ, Taylor SF, Dalack G. The effect of folate supplementation and genotype on cardiovascular and epigenetic measures in schizophrenia subjects. Npj Schizophrenia. 2015 November; 1:15046.
  • Burghardt KJ, Thomas ST, Tutag-Lehr V. Off-label use of duloxetine for pediatric neuropathic pain. 2015 November; 5(6):277-283.
  • Burghardt KJ, Evans SJ, Wiese KM, Ellingrod VL. An Untargeted Metabolomics Analysis of Antipsychotic Use in Bipolar Disorder. Clinical and translational science. 2015; 8(5):432-40.
  • Burghardt KJ, Goodrich JM, Dolinoy DC, EllingrodVL. DNA methylation, insulin resistance and second generation antipsychotics (SGA) in bipolar disorder. Epigenomics. 2015; 7(3):343-52.
  • Bly MJ, Taylor SF, Dalack G, Pop-Busui R, Burghardt KJ, Evans SJ, McInnis MI, Grove TB, Brook RD, Zöllner SK, Ellingrod VL. Metabolic syndrome in bipolar disorder and schizophrenia: dietary and lifestyle factors compared to the general population. Bipolar Disord. 2014 May;16(3):277-88.
  • Burghardt K, Grove T, Ellingrod V. Endothelial nitric oxide synthetase genetic variants, metabolic syndrome and endothelial function in schizophrenia. J Psychopharmacol. 2014 Apr;28(4):349-56
  • Bostwick JR, Burghardt KJ, Choe HM, Deneke E, Fluent T. Opportunities to partner with clinical pharmacists in ambulatory psychiatry. Current Psychiatry 2014 July;13(7):23-29.