Wayne State University
Serrine S. Lau Ph.D.

To live is the rarest thing in the world, most people exist, that is all.

Oscar Wilde

Serrine S. Lau Ph.D.

Dean and Professor, Pharmaceutical Sciences

Contact

313-577-1574
serrine.lau@wayne.edu

Appointments

 Dean, Eugene Applebaum College of Pharmacy and Health Sciences

Professor, Department of Pharmaceutical Sciences

Degrees and Certifications

  • Ph.D., University of Michigan (Major: Pharmacology), 1980
  • B.S., University of Houston (Major: Mathematics and Chemistry), 1974

Positions and Employment

  • 2016-present, Dean and Professor, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI
  • 2013-2015, Director, Arizona Board of Regents Center for Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ
  • 2003-2015, Director, Southwest Environmental Health Sciences Center, Center for Toxicology, University of Arizona, Tucson, AZ
  • 2003-2015, Professor, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ
  • 1996-2003, Director, Analytical Instrumentation Facility Core, Center for Research on Environmental Disease
  • 1996-2003, Adjunct Professor, Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park Research Division, Smithville, TX
  • 1996-2003, Director, Toxicology Training Program, College of Pharmacy, The University of Texas, Austin, TX
  • 1995-2003, Professor, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas, Austin, TX
  • 1990-1995, Associate Professor, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas, Austin, TX
  • 1986-1990, Assistant Professor, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas, Austin, TX
  • 1983-1986, Senior Staff Fellow, Laboratory of Experimental Therapeutics and Metabolism, National Cancer Institute, NIH, Bethesda, MD
  • 1981-1983, Visiting Fellow, Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
  • 1971-1975, Research Assistant - Institute for Lipid Research, Baylor College of Medicine, Houston, TX

Awards and Honors

  • Treasurer, HESI, 2012-2016
  • Member, Board of Trustees, The Health and Environmental Sciences Institute (HESI), 2011-2017
  • The George H. Scott Memorial Award, The Toxicology Forum, 2015
  • Member, Board of Scientific Counselors of the NIEHS, 2010-2015
  • Distinguished Chinese Toxicologist Lectureship Award, sponsored by the American Association of Chinese in Toxicology, SOT special interest group, 2009
  • Society of Toxicology Education Award, 2009
  • Committee on Human Health Risks of Trichloroethylene, an advisory committee under the National Research Council of the National Academy of Sciences, 2005-2006
  • Committee on Emerging Issues and Data on Environmental Contaiminants, an advisory committee under the National Research Council of the National Academy of Sciences, 2002-2004
  • Johnson and Johnson Centennial Professor in Pharmacy, University of Texas at Austin, 1996-2003
  • Behrens Centennial Professor in Pharmacy, University of Texas at Austin, 1995-1996
  • Alan W. Hamm Centennial Fellow of College of Pharmacy, University of Texas at Austin, 1993-1995
  • Alfred and Dorothy Mannino Fellow of College of Pharmacy, University of Texas at Austin, 1988-1993. She represents the first Endowed Assistant Professor in the history of the College of Pharmacy at the University of Texas.
  • Nominated for the Texas Excellent Teaching Award of the College of Pharmacy, The University of Texas for the years of 1989 and 1990
  • Nominated for the Best Paper Award of Drug Metabolism and Disposition, 1987, Paper title: Cooxidation of 2-bromohydroquinone by renal prostaglandin synthase. Modulation of prostaglandin synthesis by 2-bromohydroquinone and glutathione.
  • Best Paper Award of Drug Metabolism and Disposition, 1985. Awarded by the Drug Metabolism Division of American Society of Pharmacology and Experimental Therapeutics. Paper entitled “Glutathione Conjugates of 2-Bromohydroquinone are Nephrotoxic.”
  • Rackham Dissertation Grant, University of Michigan, 1979
  • Hoffman-LaRoche Fellowship, University of Michigan, 1978-1980
  • University of Michigan Cancer Research Grant, 1977
  • Barbour Scholarship, University of Michigan, 1976-1978
  • Rackham Block Grant, University of Michigan, 1975-1976
  • Pharmacology Fellowship, University of Michigan, 1975-1976

Professional Memberships

  • Phi Kappa Phi
  • Mortar Board
  • Alpha Lambda Delta
  • Rho Chi
  • American Association of Colleges of Pharmacy
  • American Association for the Advancement of Science
  • American Society of Mass Spectrometry
  • American Society of Pharmacology and Experimental Therapeutics
  • International Society for the Study of Xenobiotics
  • Society of Toxicology
  • American Chemical Society
  • American Association for Cancer Research
  • Association of Biomolecular Resource Facilities

Recent Publications

Kinsky, O.R., Hargraves, T.L., Anumol, T. Jacobsen, N.E., Dai, J., Shane A. Snyder, S.A., Monks, T.J. and Lau, S.S. Metformin scavenges methylglyoxal to form a novel imidazolinone metabolite in humans. Chem Res Toxicol, just accepted (Cover Article February issue). 2016.

Kimzey, M.J., Kinsky, O.R., Yassine, H.N., Tsaprailis, G., Monks, T.J. and Lau, S. S. Site specific modification of the human plasma proteome by methylglyoxal. Toxicol. Appl. Pharmcol., epub ahead. 2015.  PMID: 26435215

Cohen, J.D., Labenski, M.T., Mastrandrea, N.J., Monks, T.J. and Lau, S.S. Transcriptional and Post-translational Modifications of B-Raf in Quinol-Thioether Induced Tuberous Sclerosis Renal Cell Carcinoma. Mol. Carcinogenesis, epub ahead. 2015. PMID: 26333016

Lizarraga, L.E., Cholanians, A.B., Phan, A.V., Herndon, J.M., Lau, S.S. and Monks, T.J. Vesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)-methylenedioxymethamphetamine. Toxicol Sci, 143:209-218, 2014. PMID:25370842; PMCID: 4274386

Yassine, H.N., Jackson, A.M., Reaven, P.D., Nedelkov, D., Nelson, R.W., Lau, S.S. and Borchers, C.H. The Application of multiple reaction monitoring to assess apo A-I methionine oxidations in diabetes and cardiovascular disease. J Translational Proteomics, 4:18-24, 2014. PMID: 25705587; PMCID: 4331021

Yassine, H.N., Belopolskaya, A., Schall, C., Stump, C.S., Lau, S.S. and Reaven, P.D., Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes. Metabolism, 63(5):727-734, 2014. PMID: 24636347; PMCID: 4014062

Lizarraga, L.E., Phan, A.V., Cholanians, A.B., Herndon, J.M., Lau, S.S. and Monks, T.J. Serotonin reuptake transporter (SERT) deficiency modulates the acute thermoregulatory and locomotor activity response to 3,4-(±)-methylenedioxymeth-amphetamine, and attenuates depletions in serotonin levels in Sert-KO rats. Toxicol Sci, 139(2): 421-431, 2014.  PMID: 24595820; PMCID: 4031621

Zhang F., Xie, R., Munoz F., Lau S.S. and Monks T.J. PARP-1 Hyperactivation and reciprocal elevations in intracellular Ca2+ during ROS-induced nonapoptotic cell death. Toxicol Sci, 140(1):118-134, 2014. PMID: 24752504; PMCID: 4081636

Yassine, H.N., Jackson, A.M., Borges, C.R., Billheimer, D., Koh, H., Smith, D., Reaven, P., Lau, S.S. and Borchers, C.H. The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins. Journal of Lipids in Health and Disease, 13:8-18, 2014. PMID: 24397693; PMCID: 3900256

Herndon, J.M.,Cholanians, A.B, Lizarraga, L.E., Lau, S.S., and Monks, T.J. Catechol O-methyltransferase and 3,4-(±)methylenedioxy-methamphetamine toxicity. Toxicol Sci, 139(1):162-73, 2014. PMID: 24591155; PMCID: 4007109

Herndon, J.M., Cholanians, A.B, Lau, S.S., and Monks, T.J. Glial cell response to 3,4-(±)-methylenedioxymethamphetamine and its metabolites. Toxicol Sci, 138:130-138, 2014. PMID: 24299738; PMCID: 3930364

Yassine, H., Borges, C.R., Schaab, M.R., Billheimer, D., Stump, C., Reaven, P., Lau, S.S., and Nelson, R. Mass spectrometric immunoassay and MRM as targeted MS-based quantitative approaches in biomarker development: Potential applications to cardiovascular disease and diabetes. Proteomics Clin Appl, 7: 528–540, 2013. PMID: 23696124; PMCID: 4029342

Monks, T.J. and Lau, S.S. Reactive Intermediates: Molecular and MS-based approaches to assess the functional significance of chemical-protein adducts. Toxicol Pathol, 41(2):315-321, 2013. PMID: 23222993; PMCID: 4007760

Ricardo J. Flores, R.J., Li, Y., Yu, A., Jianhe Shen, J., Lau, S.S., Vannucci, M., Lau, C.C., and Man, T-K. A Systems biology approach reveals common metastatic pathways in osteosarcoma. BMC Systems Biology Journal, 6:50, 2012. PMID: 22640921; PMCID: 3431263 Highly Accessed, categorized by BioMed Central, July 23, 2012; published on May 28, 2012 and total accesses on November 29, 2012 are 1453

Zhang, F., Lau, S.S and Monks, T. J. A Dual role for poly (ADP-ribose) polymerase-1 (PARP-1) during caspase-dependent apoptosis. Toxicol Sci, 128(1):103-114, 2012. PMID: 22523229; PMCID: 3491962

Yassine, H., Kimzey, M.J., Galligan, M. A., Gandolfi, A.J., Stump, C.S. and Lau, S.S. Adjusting for urinary creatinine overestimates arsenic concentrations in diabetics. CardioRenal Medicine, 2: 26-32, 2012. PMID: 22493600; PMCID: 3318926

Cohen, J.D., Gard, J.M.C., Nagle, R.B., Dietrich, J.D. Monks, T.J. and Lau, S.S. ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether induced Tuberous Sclerosis renal cell carcinoma. Toxicol Sci, 124 (1): 75-87, 2011. PMID: 21813464; PMCID: 3196650  

Wnek, S.M., Kuhlman, C.L., Camarillo, J. M., Medeiros, M.K., Liu, K.J., Lau, S.S. and Gandolfi, A.J. Interdependent genotoxic mechanisms of monomethylarsonous acid: Role of ROS-induced DNA damage and poly (ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells. Toxicol Appl Pharm, 257: 1-13, 2011. PMID: 21925530; PMCID: 3220758

Cohen, J.D., Tham, K., Mastrandrea, N.J., Gallegos, A.C., Monks, T.J. and Lau, S.S. cAMP-Dependent cytosolic mislocalization of p27kip-cyclin D1 during quinol-thioether induced Tuberous Sclerosis renal cell carcinoma. Toxicol Sci, 122(2): 361-371, 2011. PMID: 21693435; PMCID: 3155088

Kimzey, M.J., Zarate, X., Galbraith, D.W. and Lau, S.S. Optimizing microarray-based in situ transcription-translation of proteins for matrix-assisted laser desorption ionization mass spectrometry. Anal Biochem, 414: 282-286, 2011. PMID: 21477576; PMCID: 4120701

Fisher, A.A., Labenski, M.T., Malladi, S., Chapman, J.D., Bratton, S.B., Monks, T.J. and Lau, S.S. The frequency of 1, 4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation. Toxicol Sci, 122(1):64-72, 2011. PMID: 21527774; PMCID: 3203403  

Felter, S.P., Conolly, R.B., Bercu, J.P., Bolger, P.M., Boobis, A.R., Bos, P.M.J., Carthew, P., Doerrer, N.G., Goodman, J.I., Harrouk, W.A., Kirkland, D.J., Lau, S.S., Llewellyn, G.C., Preston, R.J., Schoeny, R., Schnatter, A.R., Tritscher A., van Velsen, F. and Williams, G.M. A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens. Critical Reviews in Toxicology, 41(6): 507–544, 2011. PMID: 21591905

Felter, S.P., Conolly, R.B., Bercu, J.P., Bolger, P.M., Boobis, A.R., Bos, P.M.J., Carthew, P., Doerrer, N.G., Goodman, J.I., Harrouk, W.A., Kirkland, D.J., Lau, S.S., Llewellyn, G.C., Preston, R.J., Schoeny, R., Schnatter, A.R., Tritscher A., van Velsen, F. and Williams, G.M. A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens. Critical Reviews in Toxicology, 41(6): 507–544, 2011. PMID: 21591905

Kimzey, M.J., Yassine, H.N., Riepel, B.M., Tsaprailis, G., Monks, T.J. and Lau, S.S. New Site(s) of Methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism. Chemico-Biol Inter, 192: 122-128, 2011. PMID: 20934417; PMCID: 3050118

Labenski, M.T., Fisher, A.A., Monks, T.J., and Lau, S.S. Mass spectrometry-based methods to identify chemical modifications on proteins. IV. Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS). In: Gautier, J.-C. (Ed.). Drug Safety Evaluation Series - Methods of Molecular Medicine. Humana Press 2011; Methods Mol Biol, 691: 339-350. PMID: 20972764; PMCID: 4083842

Labenski, M.T., Fisher, A.A., Monks, T.J., and Lau, S.S. Mass spectrometry-based methods to identify chemical modifications on proteins. III. One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine. In: Gautier, J.-C. (Ed.). Drug Safety Evaluation Series - Methods of Molecular Medicine. Humana Press 2011; Methods Mol Biol, 691:327-338. PMID: 20972763; PMCID: 4096012

Fisher, A.A., Labenski, M.T., Monks, T.J, and Lau, S.S. Mass spectrometry-based methods to identify chemical modifications on proteins: II. Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro. In: Gautier, J.-C. (Ed.). Drug Safety Evaluation Series - Methods in Molecular Medicine. Humana Press 2011; Methods Mol Biol, 691: 317-326. PMID: 20972762; PMCID: 4120700

Fisher, A.A., Labenski, M.T., Monks, T.J., and Lau, S.S. Mass spectrometry-based methods to identify chemical modifications on proteins. I. Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro. In: Gautier, J.-C. (Ed.). Drug Safety Evaluation Series - Methods of Molecular Medicine. Humana Press 2011; Methods Mol Biol, 691:303-316. PMID: 20972761; PMCID: 4096023  

Monks, T.J., Butterworth, M., and Lau, S.S. The fate of benzene oxide. Chemico-Biol Inter, 184:201-206, 2010.  PMID: 20036650; PMCID: 4414400

Lau, S.S., Kuhlman, C., Bratton S.B. and Monks, T.J. Role of hydroquinone-thiol conjugates in benzene-mediated toxicity. Chemico-Biol Inter, 184: 212-217, 2010. PMID: 20034486; PMCID: 2846198

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