Kyle Burghardt, Pharm.D.

Kyle Burghardt, Pharm.D.

Associate Professor

Office Location

4154

Phone

313-577-3132

Email

kburg@wayne.edu

Department

Pharmacy Practice

Research website

https://orcid.org/0000-0003-2319-5149

Kyle Burghardt, Pharm.D.

Degrees and Certifications

Degrees
  • 2011-2014 - Post-Doctoral Research Fellow, Pharmacogenomics Lab, University of Michigan College of Pharmacy, Department of Clinical, Social and Administrative Sciences
  • 2011 - University of Michigan, College of Pharmacy, Ann Arbor, Doctorate of Pharmacy with Distinction
  • 2005-2007 - University of Michigan, College of LS&A, Pre-Pharmacy/Biochemistry
  • 2004-2005 - University of California at Santa Cruz, Pre-Pharmacy/Biochemistry
Certifications
  • 2021 - Certificate in Applied Biostatsitics, Harvard University Catalyst
  • 2019 - Certificate in Clinical Research Conduct & Management, University of California Berkeley Ext.
  • 2014 - American College of Clinical Pharmacy Focused Investigator Training Program
  • 2013 - MI Regional Comprehensive Metabolomics Resource Cores Summer Metabolomics Workshop
  • 2012 - Institute of General Medical Sciences 2nd Annual Short Course on Statistical, Genetics & Genomics
  • 2012 - Statistical Analysis with R Workshop, Michigan Center for Statistical Consultation and Research

Positions and Employment

  • 2020-present - Associate Professor of Pharmacy Practice - Tenured, Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences
  • 2014-2020 - Assistant Professor of Pharmacy Practice - Tenure Track, Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences
  • 2011-2014 - Pharmacist at Schmidt and Sons Pharmacy (Tecumseh, MI)
  • 2009 - Research Assistant with the Highland Park Project under the Ginsberg Research Grant, University of Michigan College of Pharmacy, Department of Clinical, Social and Administrative Sciences
  • 2005-2006 - Research Assistant in the Molecular and Behavioral Neuroscience Institute Watson/Akil Lab, University of Michigan School of Medicine

Awards and Honors

  • 2023 - Wayne State University Career Development Chairs Award
  • 2020 - American College of Clinical Pharmacy New Investigator 2020 Award
  • 2019 - Original Research Award Winner for College of Psychiatric and Neurologic Pharmacist Association
  • 2017 - American College of Clinical Pharmacy Poster Accepted for CE presentation
  • 2016 - Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences College Research Day Poster Award (Mentor to Brittany Lines)
  • 2016 - Undergraduate Research Opportunity Program Grant (Mentor to Nadeen Mansour)
  • 2016 - American College of Clinical Pharmacy New Investigator Award Nomination
  • 2015 - College of Psychiatric and Neurologic Pharmacist Original Research Award
  • 2014 - American Society of Clinical Psychopharmacology (ACSP) Annual Meeting - New Investigator Award recipient
  • 2014 - Poster Award Finalist at the Schizophrenia International Research Society 2014 Meeting
  • 2012 - Travel Fellowship Award for National Institute of General Medical Sciences 2nd Annual Short Course on Statistical Genetics and Genomics
  • 2011 - Doctor of Pharmacy: Community Service Award
  • 2009-2010 - Gertrude and George Huebner Scholarship
  • 2010 - R.A. Deno Award for Significant Improvement in Scholarship

Professional Memberships

  • 2014-Present - American Association of Colleges of Pharmacy
  • 2011-Present - American College of Clinical Pharmacy
  • 2009-Present - College of Psychiatric and Neurologic Pharmacists
  • 2017 - American College of Clinical Pharmacy Grant Reviewer
  • 2012-2015 - College of Psychiatric and Neurologic Pharmacists Student Committee; Member with appointment to “Student Services” subcommittee
  • 2012-2014 - Member of the National Network of Depression Centers (NNDC) Biomarker Taskforce

Areas of Expertise

  • Pharmacoepigenetics
  • Metabolomics
  • Lipidomics
  • Antipsychotics
  • Insulin resistance

Primary Research Interest

Ongoing

  • NIH K23 Patient-Oriented Career Development Award
    Funding IC: NIDDK - K23DK118199
    “Acutely Induced Insulin Resistance by Antipsychotic Medication in Healthy Volunteers: Impact of Skeletal Muscle Epigenomic and Proteomic Mechanisms”
    Role: PI (75%)
  • American Association of Colleges of Pharmacy
    Science of Teaching and Learning Grant
    “Effects of Hands-On Personalized Genetic Testing in Pharmacogenetics Education”
    Role: Primary Investigator (5%)
  • Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences Faculty Research Award Program (FRAP) Collaborative Grant
    “The Role of Transposable Elements in Neurotoxic Effects of Chronic Methamphetamine”
    Role: Co-Primary Investigator
  • National Institutes of Health Loan Repayment Program for Extramural Clinical Research
    Funding IC: National Institute of Diabetes Digestive and Kidney Diseases (NIDDK)
    “Mechanisms of antipsychotic-induced insulin resistance in the skeletal muscle”
    NIH - L30 DK110823
    Role: Primary Investigator

Completed

  • Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences Faculty Research Award Program (FRAP) Collaborative Grant
    “Insulin Resistance Induced by Antipsychotic Medication in the Absence of Obesity: Impact of Skeletal Muscle Protein Kinase-based Mechanisms”
    Role: Primary Investigator (15%)
  • Brain & Behavior Research Foundation
    NARSAD Young Investigator Grant
    “Effects of FAAH Genotype on Fear-Related Brain Activation during Fear Extinction”
    Role: Co-Investigator (5%)
  • Michigan Diabetes Research Center (MDRC)
    P30 Pilot/Feasibility Grant
    “Insulin Resistance Induced by Antipsychotic Medication in the Absence of Weight Gain: Impact of Skeletal Muscle Epigenetic and Protein Mechanisms”
    NIH Grant 2P30-DK020572
    Role: Primary Investigator
  • American College of Clinical Pharmacy
    Futures Research Junior Investigator Grant
    “Insulin Resistance Induced by Antipsychotic Medication in the Absence of Obesity: Impact of DNA Methylation and Lipids in the Skeletal Muscle”
    Role: Primary Investigator
  • Wayne State University Office of the Vice President for Research.
    Research Mentors Program for New Faculty
    PIs: Yi and Burghardt
  • NIH: NIMH
    Sex as a Biological Variable Supplement
    “The Role of Sex in the Epigenetics of Antipsychotic-induced Metabolic Syndrome”
    PI: Ellingrod
    NIH R01 MH082784 S1
    Role: Co-I.
    Facilitate all sample preparation, analyses and data presentation. Publish results.

Recent Publications

  • Howlett BH, Kassa M, Burghardt KJ*. 1st ed. Machado-Vieira R and Soares JC (Editors). Elsevier (New York); 2022. Biomarkers in Bipolar Disorders. Chapter 15. DNA Methylation in Bipolar Disorder. Pgs. 267-286.
  • Burghardt KJ*, Mando M, Seyoum B, Yi Z, Burghardt PR. The Effect of Antipsychotic Treatment on Hormonal, Inflammatory and Metabolic Biomarkers in Healthy Volunteers; A Systematic Review and Meta-Analysis. Accepted. In Press.
  • Burghardt KJ*, Calme G, Caruso M, Howlett BH, Sanders E, Zhang X, Msallaty Z, Mallisho A, Seyoum B, Qi YA, Yi Z. Profiling the Skeletal Muscle Proteome in Patients on Atypical Antipsychotics and Mood Stabilizers. Brain Sciences (MDPI). 2022; 12(2):259.
  • Zabik NL, Iadipaolo AS, Marusak HA, Peters C, Burghardt KJ, Rabinak CA*. A Common Genetic Variant in Fatty Acid Amide Hydrolase is Linked to Alterations in Fear Extinction Neural Circuitry in a Racially Diverse, Non-Clinical Sample of Adults. Journal of Neuroscience Research. 2022 Mar;100(3):744-761.
  • Mestareehi A, Zhang X, Seyoum B, Msallaty Z, Abdullah Mallisho A, Burghardt KJ, Kowluru A, Yi Z*. Metformin Increases Protein Phosphatase 2A Activity In Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants. Journal of Diabetes Research (Hindawi). 2021 Jul 28;2021:9979234.
  • Ward KM*, Burghardt KJ, Kraal AZ, Jaeger A, Yeomans L, Mchugh C, Karnovsky A, Stringer KA, Ellingrod VL. Genetic and Metabolite Variability in One-Carbon Metabolism Applied to an Insulin Resistance Model in Patients with Schizophrenia Receiving Atypical Antipsychotics. Frontiers Neuroscience. 2021 May 25;12:623143.
  • Burghardt KJ*, Ward KM, Howlett BH, Burghardt PR. Personal Genotyping and Student Outcomes in Genetic and Pharmacogenetic Teaching; A Systematic Review and Meta-Analysis. Pharmacogenomics (Futures Medicine). 2021 May;22(7):423-433
  • Ward KM*, Taubman DS, Pasternak AL, Burghardt KJ, Ellingrod VL, Parikh SV. Teaching Psychiatric Pharmacogenomics Effectively: Evaluation of a Novel Interprofessional Online Course. Journal of the American College of Clinical Pharmacy. February 2021. 4(2). 176-183.
  • Burghardt KJ*, Howlett BH, Khoury A., Fern SM, Burghardt PR. Bibliometric data based on the Pharm.D. and Ph.D. degree in United States research-intensive colleges of pharmacy. International Journal of Pharmacy Practice. 2021 Feb 10;29(1):78-83.
  • Burghardt KJ*, Howlett BH, Khoury A., Fern SM, Burghardt PR. Three Commonly Utilized Scholarly Databases and a Social Network Site Provide Different, but Related, Metrics of Pharmacy Faculty Publication. Publications 2020, 8(2), 18.
  • Burghardt KJ*, Khoury A, Msallaty Z, Yi Z, Seyoum B. Antipsychotic Medications and DNA Methylation in Schizophrenia and Bipolar Disorder: A Systematic Review. Pharmacotherapy. Accepted 1/24/2020.
  • Burghardt KJ*, Howlett BH, Fern SM, Burghardt PR. A Bibliometric Analysis of the Top 50 NIH-Funded Colleges of Pharmacy Using Two Databases. Research in Social and Administrative Pharmacy. 2019 Oct 9. pii: S1551-7411(19)30677-1.
  • Burghardt KJ*, Howlett BH, Sanders E, Dass SE, Msallaty Z, Mallisho A, Seyoum B, Yi Z. Skeletal Muscle DNA Methylation Modifications and Psychopharmacologic Treatment in Bipolar Disorder. European Neuropsychopharmacology. 2019 Oct 18. pii: S0924-977X(19)31700-6.
  • Kraal, AZ*, Moll AC, Arvanitis NR, Ward KM, Dougherty RJ, Grove TB, Burghardt KJ, Ellingrod VL. Metabolic Syndrome is Negatively Associated with Cognition among Endothelial Nitric Oxide Synthase (eNOS)-786C carriers in Schizophrenia-Spectrum Disorders. Journal of Psychiatric Research. 2019 Oct;117:142-147.

Courses taught by Kyle Burghardt, Pharm.D.

Spring-Summer Term 2024 (future)

Winter Term 2024 (current)

Spring-Summer Term 2023

Winter Term 2023

Spring-Summer Term 2022

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