Wayne State University
Zhihui Qin Ph.D.

Zhihui Qin Ph.D.

Assistant Professor, Pharmaceutical Sciences



Office location

EACPHS, Room 3144


Assistant Professor

Department of Pharmaceutical Sciences

Degrees and Certifications

Ph.D. in Medicinal Chemistry (2000), Peking University Health Science Center

B.S. in Medicinal Chemistry (1992), Peking University Health Science Center

Positions and Employment

2013- Assistant Professor, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University.

2010-2013 Research Assistant Professor (Dr. Judy L. Bolton, Dr. Gregory R. J. Thatcher), Department of Medicinal Chemistry &Pharmacognosy, College of Pharmacy, University of Illinois at Chicago.

2005-2010 Postdoctoral Research Associate (Dr. Judy L. Bolton, Dr. Gregory R. J. Thatcher), Department of Medicinal Chemistry &Pharmacognosy, College of Pharmacy, University of Illinois at Chicago; Research: drug discovery and chemical toxicology.

2002-2004 Postdoctoral Fellow (Dr. John-Stephen Taylor), Department of Chemistry, Washington University in St. Louis; Research: nucleic acid chemistry.

2000-2002 Postdoctoral Fellow (Dr. Zhao Yu-fen), Departemnt of Chemistry, Tsinghua University, Beijing, China; Research: nucleic acid chemistry, phosphorus chemistry.

1995-2000 Graduate Research Assistant (Drs. Cai Meng-Shen, Li Zhong-Jun), Departemnt of Chemical Biology, Peking University Health Science Center, Beijing, China; Research: carbohydrate chemistry, peptide chemistry.


Areas of Expertise

Synthetic Medicinal Chemistry

Analytical Chemistry (LC-MS)

Drug Metabolism (bioactivation, biotransformation and metabolite identification)

Primary Research Interest

The current cancer drug discovery project focuses on the discovery of multifunctional hybrid drugs and drug combinations that can synergistically inhibit the growth of prostate cancer cells and leukemia cells.

Recent Publications

  1. Qin, Zhihui Modulating nitric oxide signaling in CNS for Alzheimers disease therapy (review)Future Medicinal Chemistry 2013,5(12), 1451-1468.
  2. VandeVrede, Lawren; Abdelhamid, Ramy; Qin, Zhihui; Choi, Jaewoo; Piyankarage, Sujeewa; Luo, Jia;Larson, John;Bennett, Brian M.;Thatcher, Gregory R. J. An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic riskPLOS ONE 2013, 8, e70740
  3. Qin, Zhihui;Luo, Jia;VandeVrede, Lawren; Tavassoli, Ehsan; Thatcher, Gregory R.J. Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy Journal of Medicinal Chemistry 2012, 55(15), 6784-6801.
  4. Michalsen, Bradley; Gherezghiher,Teshome; Choi, Jaewoo; Chandrasena, Esala; Qin, Zhihui;Thatcher, Gregory R.J. ; Bolton, Judy L. Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiolChemical Research in Toxicology 2012,25(7), 1472-1483.
  5. Gherezghiher, Teshome B.; Michalsen, Bradley; Chandrasena, R. Esala P.; Qin, Zhihui; Sohn, Johann; Thatcher, Gregory R. J.; Bolton, Judy L. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin Chemico-Biological Interactions2012,196(1-2),1-10.
  6. Schiefer, Isaac T.; Abdul-Hay, Samer; Wang, Huali; Vanni, Michael;Qin, Zhihui; Thatcher, Gregory R. J. Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates Journal of Medicinal Chemistry 2011, 54(7), 2293-2306.
  7. Peng, Kuan-Wei; Chang, Minsun; Wang, Yue-Ting; Wang, Zhican; Qin, Zhihui; Bolton, Judy L.; Thatcher, Gregory R. J. Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation Chemical Research in Toxicology 2010, 23(8), 1374-1383.
  8. Peng, Kuan-Wei; Wang, Huali; Qin, Zhihui; Wijewickrama, Gihani T.; Lu, Meiling; Wang, Zhican; Bolton, Judy L.; Thatcher, Gregory R. J. Selective Estrogen Receptor Modulator Delivery of Quinone Warheads to DNA Triggering Apoptosis in Breast Cancer CellsACS Chemical Biology,2009, 4(12), 1039-1049.
  9. Qin, Zhihui; Kastrati, Irida; Ashgodom,Rezene T.; Lantvit, Daniel D.; Overk, Cassia R.; Choi, Yongsoo;Van Bremen, Richard B.;Bolton, Judy L.; Thatcher, Gregory R. J. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators (SERMs) Drug metabolism and Disposition, 2009, 37(1), 161-169.
  10. Yu, Bolan; Qin, Zhihui; Wijewickrama,Gihani T.; Edirisinghe, Praneeth; Bolton, Judy L.; Thatcher, Gregory R. J. Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics Bioconjugate Chemistry, 2009, 20(4), 728-741.
  11. Wang, Zhican; Edirisinghe, Praneeth; Sohn, Johann; Qin, Zhihui; Geacintov, Nicholas E.; Thatcher, Gregory R. J.;Bolton, Judy L.Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells Chemical Research in Toxicology2009, 22(6), 1129-1136.
  12. Qin, Zhihui; Kastrati, Irida;Bolton, Judy L.; Chandrasena, R. Esala P.; Hong, Liu; Petukhov, Pavel A.;Yao, Ping.; Thatcher, Gregory R. J. Design & synthesis of benzothiophene SERMs with modulated oxidative activity & receptor affinity Journal of Medicinal Chemistry 2007, 50(11), 2682-2692.
  13. Liu, Hong, Qin, Zhihui; Thatcher, Gregory R. J.; Bolton, Judy L. Uterine peroxidase oxidizes raloxifene and desmethylated arzoxifene to diquinone methides Chemical Research in Toxicology 2007, 20(11), 1676-1684.
  14. Overk, Cassia R.; Peng, Kuan-Wei; Asghodom, Rezene T.; Kastrati, Irida; Lantvit, Daniel D.; Qin, Zhihui; Frasor, Jonna; Bolton, Judy L.; Thatcher, Gregory R. J.Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene ChemMedChem2007,2(10),1520-1526.
  15. Yu, Bolan; Dietz, Birgit M.;Dunlap,Tareisha;Kastrati, Irida;Lantvit, Daniel D.;Overk, Cassia R.;Yao, Ping;Qin, Zhihui;Bolton, Judy L.; Gregory R. J. Thatcher Structural modulation of reactivity/activity in design of improved benzothiophene SERMs: Induction of chemopreventive mechanisms Molecular Cancer Therapeutics2007,6(9),2418-2428.
  16. Chang, Minsun; Overk, Cassia; Peng, Kuanwei; Qin, Zhihui; Yao, Ping; Bolton, Judy, L.; Kastrati, Irida; Thatcher, Gregory R.J.Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cellsEndocrinology 2007, 148(10), 4793-4802.
  17. Dowers, Tamara S.; Qin, Zhi-Hui; Thatcher, Gregory R. J.; Bolton, Judy L.Bioactivation of selective estrogen receptor modulators (SERMs) Chemical Research in Toxicology 2006, 19(9), 1125-1137 (review).
  18. Huang, He-Qing; Li, Shu-Chun; Qin, Zhi-Hui; Cao, Sheng-Li; Yao, Yun; Liu, Yu-Shi; Li, Huai-Yu; Cai, Meng-Shen; Li, Zhong-Jun; Shi, You-En.Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma Bioorganic & Medicinal Chemistry Letters 2005, 15(9), 2415-2419.
  19. Qin, Zhi-Hui; Lin, Chang-Xue; Ju, Yong; Zhao, Yu-Fen Synthesis of serine/alanine conjugated 3',5'-TpTNucleosides, Nucleotides & Nucleic Acids2003,22(1),63-69.
  20. Qin, Zhi-Hui; Lin, Chang-Xue; Chen, Yi; Ju, Yong; Zhao, Yu-Fen Electrospray ionization mass spectrometry of serine/alanine conjugated 5'-UMP and 3',5'-dithymidine phosphoramidates Rapid Communications in Mass Spectrometry2002,16(20),1997-2002.
  21. Qin, Zhi-Hui; Liu, Hong; Li, Hui; Cai, Meng-Shen; Li, Zhong-Jun Synthesis of a potential tetrasaccharide ligand for E-selectinCarbohydrate Research 2002, 337(7), 621-628.
  22. Qin, Zhi-Hui; Li, Hui; Cai, Meng-Shen; Li, Zhong-Jun Bromonium ion-promoted glycosidic bond formation and simultaneous bromination of an activated aryl aglycon.Carbohydrate Research 2002, 337(1), 31-36.
  23. Qin, Zhi-Hui; Cai, Meng-shen; Li, Zhong-jun Studies on the migration of acetyl group during the process of reductive ring-opening of 4,6-O-benzylidene thioglycoside with NaBH3CN-HCl. Youji Huaxue 2001, 21(3), 214-217.
  24. Qin, Zhi-Hui; Li, Hui; Cai, Meng Shen; Li, Zhong JunSelective de-O-acetylation of tetrachlorophthaloyl (TCP)-containing glycosides with magnesium methoxide Chinese Chemical Letters2000,11(11),941-944.
  25. Cao, Sheng-Li; Qin, Zhihui; Cai, Meng-Shen; Shi, You-en Syntheses and bioactivities of multiple antigenic peptide vaccines against Schistosomiasis Yaoxue Xuebao,1999, 34(5): 368-371
  26. Xu, Jia-Xi; Qin, Zhihui; Cai, Meng-Sheng; Zhuang, Hui Chemical synthesis of antigenic peptides from proteins of hepatitis E virus and their use in serodiagnosis of HEV infection Yaoxue Xuebao, 1999, 34(4): 286-289.

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