Wayne State University
Zhihui Qin Ph.D.

Zhihui Qin Ph.D.

Assistant Professor, Pharmaceutical Sciences

Contact

313-577-1567
zqin@wayne.edu

Office location

EACPHS, Room 3144

Appointments

Assistant Professor

Department of Pharmaceutical Sciences

Degrees and Certifications

Ph.D. in Medicinal Chemistry (2000), Peking University Health Science Center

B.S. in Medicinal Chemistry (1992), Peking University Health Science Center

Positions and Employment

2013- Assistant Professor, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University.

2010-2013 Research Assistant Professor (Dr. Judy L. Bolton, Dr. Gregory R. J. Thatcher), Department of Medicinal Chemistry &Pharmacognosy, College of Pharmacy, University of Illinois at Chicago.

2005-2010 Postdoctoral Research Associate (Dr. Judy L. Bolton, Dr. Gregory R. J. Thatcher), Department of Medicinal Chemistry &Pharmacognosy, College of Pharmacy, University of Illinois at Chicago; Research: drug discovery and chemical toxicology.

2002-2004 Postdoctoral Fellow (Dr. John-Stephen Taylor), Department of Chemistry, Washington University in St. Louis; Research: nucleic acid chemistry.

2000-2002 Postdoctoral Fellow (Dr. Zhao Yu-fen), Departemnt of Chemistry, Tsinghua University, Beijing, China; Research: nucleic acid chemistry, phosphorus chemistry.

1995-2000 Graduate Research Assistant (Drs. Cai Meng-Shen, Li Zhong-Jun), Departemnt of Chemical Biology, Peking University Health Science Center, Beijing, China; Research: carbohydrate chemistry, peptide chemistry.

 

Areas of Expertise

Synthetic Medicinal Chemistry

Analytical Chemistry (LC-MS)

Drug Metabolism (bioactivation, biotransformation and metabolite identification)

Primary Research Interest

The current cancer drug discovery project focuses on the discovery of multifunctional hybrid drugs and drug combinations that can synergistically inhibit the growth of prostate cancer cells and leukemia cells.

Recent Publications

1.   Yi Liao, Xiaojia Niu, Bailing Chen, Holly Edwards, Liping Xu, Chengzhi Xie, Hai Lin, Lisa Polin, Jeffrey W. Taub, Yubin Ge, Zhihui Qin           Synthesis and antileukemic activities of piperlongumine and HDAC Inhibitor hybrids against acute myeloid leukemia cell     Journal of Medicinal Chemistry, 2016, 7974-7990.

2.  Rayna Rosati, Bailing Chen, Mugdha Patki, Thomas McFall, Siyu Ou, Elisabeth Heath, Manohar Ratnam, Zhihui Qin   Hybrid enzalutamide derivatives with histone deacetylase inhibitor activity decrease heat schock protein 90 and androgen receptor levels and inhibit viability in enzalutamide-resistant C4-4 prostate cancer cells    Molecular Pharmacology, 2016, 90(3), 225-237.

3.  Jia Luo, Sue H. Lee, Lawren VandeVrede, Zhihui Qin, Sujeewa Piyankarage, Ehsan Tavassoli, Rezene T. Asghodom, Manel Ben Aissa, Mauro Fà, Ottavio Arancio, Lan Yue, David R. Pepperberg, Gregory R. J. Thatcher   Reengineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia  BMC Neurosci 2015, 16,67-76.

4.    Vandevrede L, Tavassoli E; Luo J,; Qin, Zhihui; Yue L; Pepperberg DR; Thatcher GR. Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation. Br J Pharmacol. 2014 171(2): 389-402.   

5.    Qin, Zhihui    Modulating nitric oxide signaling in CNS for Alzheimers disease therapy (review)  Future Medicinal Chemistry 2013, 5(12), 1451-1468.

6.    VandeVrede, Lawren; Abdelhamid, Ramy; Qin, Zhihui; Choi, Jaewoo; Piyankarage, Sujeewa; Luo, Jia;Larson, John;Bennett, Brian M.;Thatcher, Gregory R. J. An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic risk  PLOS ONE 2013, 8, e70740

7.    Qin, Zhihui; Luo, Jia; VandeVrede, Lawren; Tavassoli, Ehsan; Thatcher, Gregory R.J. Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy Journal of Medicinal Chemistry 2012, 55(15), 6784-6801.

8.    Michalsen, Bradley; Gherezghiher,Teshome; Choi, Jaewoo; Chandrasena, Esala; Qin, Zhihui; Thatcher, Gregory R.J.; Bolton, Judy L. Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol  Chemical Research in Toxicology 2012, 25(7), 1472-1483.

9.    Gherezghiher, Teshome B.; Michalsen, Bradley; Chandrasena, R. Esala P.; Qin, Zhihui; Sohn, Johann; Thatcher, Gregory R. J.; Bolton, Judy L. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin    Chemico-Biological Interactions 2012,196(1-2),1-10.

10.  Schiefer, Isaac T.; Abdul-Hay, Samer; Wang, Huali; Vanni, Michael;Qin, Zhihui; Thatcher, Gregory R. J. Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates Journal of Medicinal Chemistry 2011, 54(7), 2293-2306.

11.  Peng, Kuan-Wei; Chang, Minsun; Wang, Yue-Ting; Wang, Zhican; Qin, Zhihui; Bolton, Judy L.; Thatcher, Gregory R. J. Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation Chemical Research in Toxicology 2010, 23(8), 1374-1383.

12. Peng, Kuan-Wei; Wang, Huali; Qin, Zhihui; Wijewickrama, Gihani T.; Lu, Meiling; Wang, Zhican; Bolton, Judy L.; Thatcher, Gregory R. J. Selective Esten Receptor Modulator Delivery of Quinone Warheads to DNA Triggering Apoptosis in Breast Cancer Cells  ACS Chemical Biology, 2009, 4(12), 1039-1049.

13.  Qin, Zhihui; Kastrati, Irida; Ashgodom,Rezene T.; Lantvit, Daniel D.; Overk, Cassia R.; Choi, Yongsoo; Van Bremen, Richard B.; Bolton, Judy L.; Thatcher, Gregory R. J.  Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators (SERMs)  Drug metabolism and Disposition, 2009, 37(1), 161-169.

14. Yu, Bolan; Qin, Zhihui; Wijewickrama,Gihani T.; Edirisinghe, Praneeth; Bolton, Judy L.; Thatcher, Gregory R. J. Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics  Bioconjugate Chemistry, 2009, 20(4), 728-741.

15.  Wang, Zhican; Edirisinghe, Praneeth; Sohn, Johann; Qin, Zhihui; Geacintov, Nicholas E.; Thatcher, Gregory R. J.;Bolton, Judy L.  Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells  Chemical Research in Toxicology 2009, 22(6), 1129-1136.

16.  Qin, Zhihui; Kastrati, Irida;Bolton, Judy L.; Chandrasena, R. Esala P.; Hong, Liu; Petukhov, Pavel A.;Yao, Ping.; Thatcher, Gregory R. J. Design & synthesis of benzothiophene SERMs with modulated oxidative activity & receptor affinity Journal of Medicinal Chemistry 2007, 50(11), 2682-2692.

17. Liu, Hong, Qin, Zhihui; Thatcher, Gregory R. J.; Bolton, Judy L. Uterine peroxidase oxidizes raloxifene and desmethylated arzoxifene to diquinone methides    Chemical Research in Toxicology 2007, 20(11), 1676-1684.

18. Overk, Cassia R.; Peng, Kuan-Wei; Asghodom, Rezene T.; Kastrati, Irida; Lantvit, Daniel D.; Qin, Zhihui; Frasor, Jonna; Bolton, Judy L.; Thatcher, Gregory R. J.Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene  ChemMedChem 2007,2(10),1520-1526.

19.  Yu, Bolan; Dietz, Birgit M.;Dunlap,Tareisha;Kastrati, Irida;Lantvit, Daniel D.;Overk, Cassia R.; Yao, Ping; Qin, Zhihui; Bolton, Judy L.; Gregory R. J. Thatcher Structural modulation of reactivity/activity in design of improved benzothiophene SERMs: Induction of chemopreventive mechanisms Molecular Cancer Therapeutics  2007,6(9),2418-2428.

20. Chang, Minsun; Overk, Cassia; Peng, Kuanwei; Qin, Zhihui; Yao, Ping; Bolton, Judy, L.; Kastrati, Irida; Thatcher, Gregory R.J.Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells Endocrinology 2007, 148(10), 4793-4802.

21. Dowers, Tamara S.; Qin, Zhi-Hui; Thatcher, Gregory R. J.; Bolton, Judy L.  Bioactivation of selective estrogen receptor modulators (SERMs) Chemical Research in Toxicology 2006, 19(9), 1125-1137 (review).

22. Huang, He-Qing; Li, Shu-Chun; Qin, Zhi-Hui; Cao, Sheng-Li; Yao, Yun; Liu, Yu-Shi; Li, Huai-Yu; Cai, Meng-Shen; Li, Zhong-Jun; Shi, You-En.Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma  Bioorganic & Medicinal Chemistry Letters 2005, 15(9), 2415-2419.

23. Qin, Zhi-Hui; Lin, Chang-Xue; Ju, Yong; Zhao, Yu-Fen Synthesis of serine/alanine conjugated 3',5'-TpT  Nucleosides, Nucleotides & Nucleic Acids  2003,22(1),63-69.

24. Qin, Zhi-Hui; Lin, Chang-Xue; Chen, Yi; Ju, Yong; Zhao, Yu-Fen Electrospray ionization mass spectrometry of serine/alanine conjugated 5'-UMP and 3',5'-dithymidine phosphoramidates   Rapid Communications in Mass Spectrometry 2002,16(20),1997-2002.

25. Qin, Zhi-Hui; Liu, Hong; Li, Hui; Cai, Meng-Shen; Li, Zhong-Jun Synthesis of a potential tetrasaccharide ligand for E-selectin  Carbohydrate Research 2002, 337(7), 621-628.

26. Qin, Zhi-Hui; Li, Hui; Cai, Meng-Shen; Li, Zhong-Jun Bromonium ion-promoted glycosidic bond formation and simultaneous bromination of an activated aryl aglycon. Carbohydrate Research 2002, 337(1), 31-36.

 

Research Connect link

https://researchconnect.wayne.edu/en/persons/zhihui-qin

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