
Hosam Abdelhady Ph.D., M.S.
Title
Part-Time Faculty
Department
Pharmaceutical Sciences
Hosam Abdelhady Ph.D., M.S.
Degrees and Certifications
- PhD in Pharmacy with specialization in genetic nano-formulation and molecular biophysics (4D Atomic Force Microscopy Imaging, and nano-mechanics), Nottingham University, Nottingham, UK (2004)
- Master of Pharmacy in drug formulation, Cairo University, Egypt (1999)
- Bachelor of Pharmacy, Tripoli University, Libya (1993)
Positions and Employment
- Part Time Faculty, Eugene Applebaum College of Pharmacy, Wayne State University, Detroit, MI, December 2018-Current. (Teaching: PharmD program & Postgraduates)
- Adjunct Professor, Chemistry and Biochemistry Department, Central Michigan University (CMU), September 2018-December 2018
- Assistant/Associate Professor, Pharmaceutical Sciences and Molecular Biophysics, established and Led the advanced Nano-formulation and Bio-nano-imaging lab, Taibah University, Al Madinah Al Munawarrah, Saudi Arabia, 2010- 2018
- Senior scientist established and led the nano-analytical department, Dendritic Nanotechnologies, Central Michigan University Research Corporation, Mount Pleasant, MI, 2006-2009
- Postdoctoral/Assistant Professor, Chemistry Department, Central Michigan University. 2004-2006. Established the Real-Time Atomic Force Microscopy Imaging Lab
- Research Scientist, Bioavailability center, National Organization for Drug Quality Control & Research (equivalent to FDA)-Cairo-Egypt. 1993-2000
Leadership
- Chair of the department of Pharmaceutics and industrial Pharmacy, college of pharmacy, Taibah University, Saudi Arabia, 2010-2011.
- Director of the nanoanalytical department, Dendritic Nanotechnologies, CMURC, Mount Pleasant, MI, 2006-2008.
- President, MSA, CMU, MI, 2005-2006.
- President, Egyptian Society, 2003-2004-Nottingham, UK.
- Treasurer, MSA, Nottingham University, UK, 2002-2003.
Teaching area (courses, labs and tutorials)
Biopharmaceutics, Pharmacokinetics, Pharmaceutical Nanotechnologies, Pharmaceutical calculations, Physical Pharmacy, Novel Drug Delivery systems, Principles of Pharmacotherapy, Pharmacotherapeutic Problem Solving, Biophysics, and Bionanotechnology
Awards and Honors
- King Abdulaziz City for Science and Technology (KACST) Grant of $500,000 to 4D AFM imaging of the effect of suicidal gene nano-systems on cancer cells, 2013
- Golden Medal -4th International Workshop on Ultra Fast Laser Technology and Application 8, 2012 Cairo, Egypt
- KACST Grant of ~ ($500,000) to build a nano-lab for 4DAFM-biomolecular imaging, Taibah University, KSA, 2011
- CMU, $12,500, developing the first dendritic Quantum dot device- 2005
- The University of Nottingham grant, $1500 (international conference), 2003
- PhD grant, $120,000, Egyptian Ministry of Higher education. 1999
Professional Memberships
- Control Release Society
- Biophysical Society
- American Chemical Society
Primary Research Interest
- Formulation of theranostic nanoparticles for targeted cancer therapy (pancreatic stroma & Glioblastoma), gene silencing and drug delivery
- 4D Atomic Force Microscopy (4D AFM) investigations of the effect of AuNPs (anti-cancer nanoparticles) on DNA and chromosomal damage (genotoxicity)
- Biostatistics, bioavailability, and stability studies
- Developed and validated many analytical methods for hundreds of Nanomedical polymeric molecules with different functional groups and large molecular weight range (few tens of Da to 1 mega Da)
Techniques
4 Dimensions Atomic Force Microscopy (4D AFM), TEM, UPLC-ESI-TOF-MS, NMR, SEC, IC, Gel electrophoresis, UV/vis, FTIR, Florescence, DSC, TGA, USP dissolution profiles, disintegration, friability testing, and automatic titrations using different probes and applying first and second derivatives & using ASTM when needed.
Patents
- Title: Bio-Nano Power Cells and Their Uses
- Inventors: Nathan R. Long, Jie Wang, Hosam Gharib Abdelhady
- International Publication #WO2015030725
Recent Publications
- Fulwah Yahya Alqahtani, Fadilah Sfouq Aleanizy, Eram El Tahir, Bushra T. Alquadeib,Ibrahim A. Alsarra, Jouri S. Alanazi, Hosam Gharib Abdelhady. Preparation, characterization, and antibacterial activity of diclofenac-loaded chitosan nanoparticles. Saudi Pharmaceutical Journal, 27(2019), Pages 82-87.
- Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Gamal Shazly, Rihaf Alfaraj, Ibrahim Alsarra, Aws Alshamsan, Hosam G Abdelhady. Measurement and evaluation of the effects of pH gradients on the antimicrobial and antivirulence activities of chitosan nanoparticles in Pseudomonas aeruginosa. Saudi Pharmaceutical Journal 26 (2017)79–83.
- Hosam G. Abdelhady, Hassan A. Abdel-Salam, Esmaeel M. Niazy, Anja Mueller, Matthew J. Quast, Ahmed M. Effat, Serag-Eldin I. Elbehairi. Spatiotemporal PFQNM visualization of the effect of suicide dendriplexes on dividing HeLa cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12, 2365-2371.
- Hosam G Abdelhady, Yen-Ling, Haiping Sund, and Mohamed ElSayed. Visualizing the Attack of RNase Enzymes on Dendriplexes and Naked RNA Using Atomic Force Microscopy. PLOS ONE, 2013, 8(40), e61710.
- Hosam G. Abdelhady. Morphological and Nanomechanical Investigations of Magnevist Nano-encapsulated Dendrimers by Atomic Force Microscopy. LJPCP, 1, 1-8, 2012.
- Hosam G. Abdelhady. Fast Sensitive UPLC ESI Time of Flight Mass Spectroscopy Determination of Diethanolamine in Small Dendritic Nanomolecules. J T U Med Sc, 6, 2, 2011.
- Minghui Chai, Anton W. Jensen, Hosam G. Abdelhady, and Donald A. Tomalia. AFM Analysis of C60 and A PAMAM Dendrimer-C60 Nanoconjugate. Journal Nanoscience and Nanotechnology. 7(4-5), 1401-1405(5), 2007.
- Unique steric and geometry induced stoichiometries observed in the divergent synthesis of poly(ester-acrylate/amine) (PEA) dendrimers. Douglas R. Swanson, Baohua Huang, Hosam G. Abdelhady and Donald A. Tomalia, New J. Chem., 31, 1368. 2007.
- Hosam G. Abdelhady et al. Towards nanoscale metrology for biomolecular imaging by atomic force microscopy. Nanotechnology 16, 2005, 966-973.
- E. Kleemann, L. A. Dailey, H. G. Abdelhady, T. Gessler, T. Schmehl, C. J. Roberts, M. C. Davies, W. Seeger, T. Kissel . Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy. Journal of Controlled Release 100, 2004, 437–450.
- Hosam G. Abdelhady, Stephanie Allen, Martyn C. Davies, Clive J. Roberts, Saul J.B. Tendler & Philip M. Williams. Atomic Force Microscopy Studies of Generation 4 Poly (amidoamine) (PAMAM) Dendrimers on Functionalized Surfaces. Surface Science 558, 2004, 99–110.
- Ellis, J.S*., Abdelhady, HG*, Allen, S., Davies, MC., Tendler, SJB, Williams PM & Roberts, CJ. Direct atomic force microscopy observations of monovalent ion induced binding of DNA to mica. Journal of Microscopy, 215, 2004 297-301. (joint first author)
- Hosam G. Abdelhady, Stephanie Allen, Martyn C. Davies, Clive J. Roberts, Saul J.B. Tendler & Philip M. Williams. Direct real time molecular scale visualization of the degradation of condensed DNA complexes exposed to DNase I. Nucleic Acid Research. 31(14) 2003, 4001-4005.
Book chapter
- Hosam G Abdelhady. Dendrimers DNA Nanoplexes, in CRC Concise Encyclopedia of Nanotechnology, editor {Ildusovich, Kharisov and Vasilievna, Kharissova and Ortiz-Mendez}, CRC Press, 2015.
Conference proceeding and newsletters
- Hosam G. Abdelhady. The Formation and Deformation of an Individual DNA Toroid in 4D. Ultrafast of laser technology and application (UFLTA) 2012 conference proceeding.
- C.E. Madden, J. Zhang, H.G. Abdelhady, N. Patel, C.J. Roberts, S Allen. Size Matters: Biometrology for AFM. Nanovations, Veeco European newsletter, Spring 2004.
Presentations and invited talks
- Invited Speaker, Insight Institute of Neurosurgery & Neuroscience, Flint, MI, Feb 2019.
- Invited speaker, Field Institute of Neuroscience, Saginaw, MI, April 2019.
- Invited speaker, Michigan center for material characterization, University of Michigan Ann Arbor, September 26th, 2018.
- Invited Speaker, 6th International Conference on Modern Trends in Physics (MTP), Egypt- December 2016.
- Speaker at 2nd World Bio Summit & Expo, Dubai, UAE, October 2016.
- Speaker at 5th KIPC, Kuwait, February 2015.
- Invited Speaker, 5th International Conference on MTP, Egypt- December 2014
- Invited speaker, Department of Astronomy, Ohio state University. August 1st, 2012.
- Invited Speaker International Conference of Photodynamic and Nanomedicine for Cancer Diagnosis and Therapy- GUC-Egypt. February 2012.
- Speaker at "Seeing at Nanoscal" University of California, Santa Barbara, USA. Jul 2011.
- Speaker at Bruker, Santa Barbara, USA. Aug 2011.
- Speaker, 3rd ICDDT –Dubai-Feb-2011.
- Speaker, 4th Saudi science conference. Mar 2010.
- Invited speaker- 1st Alexandria International Congress on Tissue Engineering-Egypt Feb 2009.
- Invited speaker, Materials and Process Simulation Center, Caltech Jan 2009.
- Invited Speaker, Wayne state university-MI-USA. Size Matters: Biometrology for AFM. Feb 2007.
- Periodic Patterns, Relationships and Categories of Well-Defined Nanoscale Building Blocks, NSF, 2007.
- Invited Speaker, Broad Institute-MIT and Harvard. Aug 2006. Physical & chemical characterizations of PAMAM dendrimers by Atomic force microscopy in real time.
- Invited Speaker, Chemical engineering, MIT- Aug 2006. Real time molecular scale investigations of biomaterials.
- Invited Speaker, Harvard Medical School, 2005. Investigation of novel polymers; a real time molecular scale studies by Pico-Newton forces.
- Invited Speaker, 4th IDS-CMU-Michigan. 2005. AFM characterizations of priostars.