Hosam Abdelhady Ph.D., M.S.

Degrees and Certifications

• PhD in Pharmacy with specialization in genetic nano-formulation and molecular biophysics (4D Atomic Force Microscopy Imaging, and nano-mechanics), Nottingham University, Nottingham, UK (2004)
• Master of Pharmacy in drug formulation, Cairo University, Egypt (1999)
• Bachelor of Pharmacy, Tripoli University, Libya (1993)

Positions and Employment

• Part Time Faculty, Eugene Applebaum College of Pharmacy, Wayne State University, Detroit, MI, December 2018-Current. (Teaching: PharmD program & Postgraduates)
• Adjunct Professor, Chemistry and Biochemistry Department, Central Michigan University (CMU), September 2018-December 2018
• Assistant/Associate Professor, Pharmaceutical Sciences and Molecular Biophysics, established and Led the advanced Nano-formulation and Bio-nano-imaging lab, Taibah University, Al Madinah Al Munawarrah, Saudi Arabia, 2010- 2018
• Senior scientist established and led the nano-analytical department, Dendritic Nanotechnologies, Central Michigan University Research Corporation, Mount Pleasant, MI, 2006-2009
• Postdoctoral/Assistant Professor, Chemistry Department, Central Michigan University. 2004-2006. Established the Real-Time Atomic Force Microscopy Imaging Lab
• Research Scientist, Bioavailability center, National Organization for Drug Quality Control & Research (equivalent to FDA)-Cairo-Egypt. 1993-2000

Leadership 

• Chair of the department of Pharmaceutics and industrial Pharmacy, college of pharmacy, Taibah University, Saudi Arabia, 2010-2011.
• Director of the nanoanalytical department, Dendritic Nanotechnologies, CMURC, Mount Pleasant, MI, 2006-2008.
• President, MSA, CMU, MI, 2005-2006. 
• President, Egyptian Society, 2003-2004-Nottingham, UK.
• Treasurer, MSA, Nottingham University, UK, 2002-2003. 

Teaching area (courses, labs and tutorials)

Biopharmaceutics, Pharmacokinetics, Pharmaceutical Nanotechnologies, Pharmaceutical calculations, Physical Pharmacy, Novel Drug Delivery systems, Principles of Pharmacotherapy, Pharmacotherapeutic Problem Solving, Biophysics, and Bionanotechnology

Awards and Honors

• King Abdulaziz City for Science and Technology (KACST) Grant of $500,000 to 4D AFM imaging of the effect of suicidal gene nano-systems on cancer cells, 2013
• Golden Medal -4th International Workshop on Ultra Fast Laser Technology and Application 8, 2012 Cairo, Egypt
• KACST Grant of ~ ($500,000) to build a nano-lab for 4DAFM-biomolecular imaging, Taibah University, KSA, 2011
• CMU, $12,500, developing the first dendritic Quantum dot device- 2005
• The University of Nottingham grant, $1500 (international conference), 2003
• PhD grant, $120,000, Egyptian Ministry of Higher education. 1999

Professional Memberships

• Control Release Society
• Biophysical Society
• American Chemical Society

Primary Research Interest

• Formulation of theranostic nanoparticles for targeted cancer therapy (pancreatic stroma & Glioblastoma), gene silencing and drug delivery
• 4D Atomic Force Microscopy (4D AFM) investigations of the effect of AuNPs (anti-cancer nanoparticles) on DNA and chromosomal damage (genotoxicity)
• Biostatistics, bioavailability, and stability studies
• Developed and validated many analytical methods for hundreds of Nanomedical polymeric molecules with different functional groups and large molecular weight range (few tens of Da to 1 mega Da)

Techniques

 

4 Dimensions Atomic Force Microscopy (4D AFM), TEM, UPLC-ESI-TOF-MS, NMR, SEC, IC, Gel electrophoresis, UV/vis, FTIR, Florescence, DSC, TGA, USP dissolution profiles, disintegration, friability testing, and automatic titrations using different probes and applying first and second derivatives & using ASTM when needed.

Patents

• Title: Bio-Nano Power Cells and Their Uses
• Inventors: Nathan R. Long, Jie Wang, Hosam Gharib Abdelhady
• International Publication #WO2015030725

Recent Publications

1. Fulwah Yahya Alqahtani, Fadilah Sfouq Aleanizy, Eram El Tahir, Bushra T. Alquadeib,Ibrahim A. Alsarra, Jouri S. Alanazi, Hosam Gharib Abdelhady. Preparation, characterization, and antibacterial activity of diclofenac-loaded chitosan nanoparticles. Saudi Pharmaceutical Journal, 27(2019), Pages 82-87.
2. Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Gamal Shazly, Rihaf Alfaraj, Ibrahim Alsarra, Aws Alshamsan, Hosam G Abdelhady. Measurement and evaluation of the effects of pH gradients on the antimicrobial and antivirulence activities of chitosan nanoparticles in Pseudomonas aeruginosa. Saudi Pharmaceutical Journal 26 (2017)79–83.
3. Hosam G. Abdelhady, Hassan A. Abdel-Salam, Esmaeel M. Niazy, Anja Mueller, Matthew J. Quast, Ahmed M. Effat, Serag-Eldin I. Elbehairi. Spatiotemporal PFQNM visualization of the effect of suicide dendriplexes on dividing HeLa cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12, 2365-2371.
4. Hosam G Abdelhady, Yen-Ling, Haiping Sund, and Mohamed ElSayed. Visualizing the Attack of RNase Enzymes on Dendriplexes and Naked RNA Using Atomic Force Microscopy. PLOS ONE, 2013, 8(40), e61710.
5. Hosam G. Abdelhady. Morphological and Nanomechanical Investigations of Magnevist Nano-encapsulated Dendrimers by Atomic Force Microscopy. LJPCP, 1, 1-8, 2012.
6. Hosam G. Abdelhady. Fast Sensitive UPLC ESI Time of Flight Mass Spectroscopy Determination of Diethanolamine in Small Dendritic Nanomolecules. J T U Med Sc, 6, 2, 2011.
7. Minghui Chai, Anton W. Jensen, Hosam G. Abdelhady, and Donald A. Tomalia. AFM Analysis of C60 and A PAMAM Dendrimer-C60 Nanoconjugate. Journal Nanoscience and Nanotechnology. 7(4-5), 1401-1405(5), 2007.
8. Unique steric and geometry induced stoichiometries observed in the divergent synthesis of poly(ester-acrylate/amine) (PEA) dendrimers. Douglas R. Swanson, Baohua Huang, Hosam G. Abdelhady and Donald A. Tomalia, New J. Chem., 31, 1368. 2007.
9. Hosam G. Abdelhady et al. Towards nanoscale metrology for biomolecular imaging by atomic force microscopy. Nanotechnology 16, 2005, 966-973.
10. E. Kleemann, L. A. Dailey, H. G. Abdelhady, T. Gessler, T. Schmehl, C. J. Roberts, M. C. Davies, W. Seeger, T. Kissel . Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy. Journal of Controlled Release 100, 2004, 437–450.
11. Hosam G. Abdelhady, Stephanie Allen, Martyn C. Davies, Clive J. Roberts, Saul J.B. Tendler & Philip M. Williams. Atomic Force Microscopy Studies of Generation 4 Poly (amidoamine) (PAMAM) Dendrimers on Functionalized Surfaces. Surface Science 558, 2004, 99–110.
12. Ellis, J.S*., Abdelhady, HG*, Allen, S., Davies, MC., Tendler, SJB, Williams PM & Roberts, CJ. Direct atomic force microscopy observations of monovalent ion induced binding of DNA to mica. Journal of Microscopy, 215, 2004 297-301. (joint first author)
13. Hosam G. Abdelhady, Stephanie Allen, Martyn C. Davies, Clive J. Roberts, Saul J.B. Tendler & Philip M. Williams. Direct real time molecular scale visualization of the degradation of condensed DNA complexes exposed to DNase I. Nucleic Acid Research. 31(14) 2003, 4001-4005.

Book chapter

1. Hosam G Abdelhady. Dendrimers DNA Nanoplexes, in CRC Concise Encyclopedia of Nanotechnology, editor {Ildusovich, Kharisov and Vasilievna, Kharissova and Ortiz-Mendez}, CRC Press, 2015.

Conference proceeding and newsletters

1. Hosam G. Abdelhady. The Formation and Deformation of an Individual DNA Toroid in 4D. Ultrafast of laser technology and application (UFLTA) 2012 conference proceeding.
2. C.E. Madden, J. Zhang, H.G. Abdelhady, N. Patel, C.J. Roberts, S Allen. Size Matters: Biometrology for AFM. Nanovations, Veeco European newsletter, Spring 2004.

Presentations and invited talks

1. Invited Speaker, Insight Institute of Neurosurgery & Neuroscience, Flint, MI, Feb 2019.
2. Invited speaker, Field Institute of Neuroscience, Saginaw, MI, April 2019.
3. Invited speaker, Michigan center for material characterization, University of Michigan Ann Arbor, September 26th, 2018.
4. Invited Speaker, 6th International Conference on Modern Trends in Physics (MTP), Egypt- December 2016.
5. Speaker at 2nd World Bio Summit & Expo, Dubai, UAE, October 2016.
6. Speaker at 5th KIPC, Kuwait, February 2015.
7. Invited Speaker, 5th International Conference on MTP, Egypt- December 2014
8. Invited speaker, Department of Astronomy, Ohio state University. August 1st, 2012.
9. Invited Speaker International Conference of Photodynamic and Nanomedicine for Cancer Diagnosis and Therapy- GUC-Egypt. February 2012.
10. Speaker at "Seeing at Nanoscal" University of California, Santa Barbara, USA. Jul 2011.
11. Speaker at Bruker, Santa Barbara, USA. Aug 2011.
12. Speaker, 3rd ICDDT –Dubai-Feb-2011.
13. Speaker, 4th Saudi science conference. Mar 2010.
14. Invited speaker- 1st Alexandria International Congress on Tissue Engineering-Egypt Feb 2009.
15. Invited speaker, Materials and Process Simulation Center, Caltech Jan 2009.
16. Invited Speaker, Wayne state university-MI-USA. Size Matters: Biometrology for AFM. Feb 2007.
17. Periodic Patterns, Relationships and Categories of Well-Defined Nanoscale Building Blocks, NSF, 2007.
18. Invited Speaker, Broad Institute-MIT and Harvard. Aug 2006. Physical & chemical characterizations of PAMAM dendrimers by Atomic force microscopy in real time.
19. Invited Speaker, Chemical engineering, MIT- Aug 2006. Real time molecular scale investigations of biomaterials.
20. Invited Speaker, Harvard Medical School, 2005. Investigation of novel polymers; a real time molecular scale studies by Pico-Newton forces.
21. Invited Speaker, 4th IDS-CMU-Michigan. 2005. AFM characterizations of priostars.

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