Wayne State University
Anjaneyulu Kowluru Ph.D.

Anjaneyulu Kowluru Ph.D.

Distinguished Professor and Associate Dean

Contact

313-577-5490
akowluru@med.wayne.edu

Office location

EACPHS, Room 3617

Appointments

Distinguished Professor and Associate Dean for External Scientific Affairs

Degrees and Certifications

B.Sc [Botany, Zoology and Chemistry] Andhra University, India
M.Sc [Agricultural Biochemistry] Allahabad University, India
Ph.D. [Biochemistry] Indian Institute of Technology, Delhi, India
Post-Doctoral Fellow, Brussels Free University School of Medicine, Brussels, Belgium
JDRF Fellow, University of Wisconsin School of Medicine, Madison, WI. USA

Positions and Employment

Staff Scientist, Division of Life Sciences, Los Alamos National Laboratory, Los Alamos, NM [1984-1991]
Senior Scientist, Department of Medicine, University of Wisconsin-Madison, and Health Science Specialist, VA
Medical Center-Madison, WI [1991-1998]
Associate Professor, Department of Pharmaceutical Sciences, Wayne State University, and Research Scientist, VA Medical Center-Detroit [1998-2001]
Research Career Scientist-VA Medical Center-Detroit [2001-2006]
Professor-Transplant Program, Department of Surgery, Wayne State University and Professor
[with tenure], Department of Pharmaceutical Sciences, Wayne State University [2001-present]
Senior Research Career Scientist, John D. Dingell VA Medical Center, Detroit [2004-present]
Member, Michigan Diabetes Research and Training Center [2001-present]
Chair, Research and Development Committee, JDD VA Medical Center, Detroit [2012-2014]
Associate Dean for External Scientific Affairs, College of Pharmacy, Wayne State University [2012-present]
Adjunct Professor, School of Biomedical Sciences, Curtin University, Perth, Australia [2013-present]
Adjunct Professor, Interdisciplinary Science and Technology Research Academy, University of Pune, India
[2014-present]
Member, Diabetes and Obesity Team Science Group, Wayne State University, Detroit [2014-present]
Deputy ACOS-R&D, John D. Dingell VA Medical Center, Detroit [2015-present]

Awards and Honors

Junior and Senior Research Fellowships, Council of Scientific and Industrial Research, India [1974-1979] Fellow of the Belgian Institute for Research in Scientific Industry and Agriculture, Belgium [1979-1981]
Fellow, Juvenile Diabetes Research Foundation [1982-1984]
Coordinator, Diabetes Research Training Program, VA Medical Center, Detroit [2001-2015]
Visiting Professor [Burroughs Wellcome Trust], University of Keele, Staffordshire, UK [2001]
Visiting Professor, National University of Singapore, Singapore [2001]
Board of Governors Charles H. Gershenson Distinguished Faculty Fellow [2004]
Elected Member-WSU Academy of Scholars [2006]
Visiting Professor, University of Dundee, Scotland [2006]
Bayard D. Catherwood Memorial Lecture, Emory University School of Medicine [2010]
Visiting Professor, Curtin University, Perth, Western Australia [2014]
Professor, Interdisciplinary Science and Technology Research Academy, University of Pune, India [2014]
Distinguished Graduate Faculty Award, Wayne State University [2015]
Distinguished Professor, Wayne State University [2017]
 

                          

 

                                                                                                                       

Professional Memberships

Current Membership in Professional Societies

American Diabetes Association
American Society of Biochemistry and Molecular Biology
American Society for Cell Biology
Association for Research in Vision and Ophthalmology
American Physiological Society
American Association for Pharmaceutical Scientists
Endocrine Society
European Association for the Study of Diabetes
Islet Society
Alpha Chi Chapter on National Pharmacy Honor Society, Wayne State University
Life member, Atherosclerosis Society-India
Life Member, Research Society for the Study of Diabetes-India
Life Member, Free Radical Society-India
Society for Free Radical Biology and Medicine
AAPS-Clinical Pharmacology and Translational Research Section
AAPS-Drug Discovery and Development Interface Section

Membership- Journal Editorial Boards

Endocrinology [2000-04]
American Journal of Physiology: Endocrinology and Metabolism [2000-2012]
Associate Editor, Experimental Diabetes Research [2008-2011]
Regional Editor, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery [2005-present]
Biochemical Pharmacology [2007-present]
Islets [2008-present]
Review Editor, Frontiers in Endocrinology [2013-present] The Open Enzyme Inhibition Journal [2007-present]
The Open Nitric Oxide Journal [2007-2010]
Metabolic and Functional Research on Diabetes [2008-present]
JOP- Journal of Pancreas [2009-present]
Journal of Membrane Science and Technology [2010-present]
Journal of Diabetes and Metabolism [2010-present]
OA Diabetes [London; 2013-present]
International Journal of Diabetology and Vascular Disease Research [2013-present]
American Journal of Physiology-Endocrinology and Metabolism [2015-present]

Manuscript Reviewer- Peer Reviewed Journals

Acta Diabetologica
American J of Physiology
Biochemistry
Biochemistry and Cell Biology
Biochemical Pharmacology
Biochimica Biophysica Acta
Cellular Physiology and Biochemistry
Diabetes
Diabetologia
Endocrinology
Endocrine
Endocrine Metabolism and Immune Drug Discovery
Endocrine Research
Expert Review of Endocrinology and Metabolism
European Journal of Pharmacology
FEBS Letters
Hormone and Metabolic Research
International Journal of Experimental Diabetes Research
International Journal of Biochemistry and Cell Biology
Journal of Biomedicine and Biotechnology
Journal of Cell Science
Journal of Diabetes Research
Journal of Endocrinology
Journal of Free Radical Biology and Medicine
Journal of Histochemistry and Cytochemistry
Journal of Molecular Endocrinology
Journal of Nutrition
Journal of Nutrition and Metabolism
Journal of Molecular and Cellular Biochemistry
Journal of Pathology
Journal of Pancreas
Journal of Toxicology
Lipids
Metabolism
Molecular and Cellular Biochemistry
Molecular and Cellular Endocrinology
Molecular Endocrinology
Molecular Pharmaceutics
Pancreas
Proceedings of National Academy of Sciences, USA
Plos ONE
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Scientific Reports [Nature Publishing]
Toxicology and Applied Pharmacology
 

Membership on Grant Review Panels
Regular member, American Diabetes Association; National Affiliate [1999-2002]
Endocrinology Subcommittee - Department of VA [2000-2003]
Regular member, Department of VA Non-Clinician Eligibility Review Panel [2008-2010]
Special Emphasis Review Panel-Nutrition and Metabolic Sciences NIDDK [1999-2001]
Innovative Partnerships in type 1 Diabetes NIDDK [2004]
Cellular Aspects of Diabetes and Obesity; NIDDK [2007-2008]
Medical Research Review Committee, Juvenile Diabetes Research Foundation [2008-2011]
Research Grant Council of Hong Kong [2011]
Regular member Cellular Aspects of Diabetes and Obesity Study Section NIDDK [2008-2012]
Diabetes UK Program [2003-present]
Burroughs Wellcome Trust [2004]
Department of VA Merit Review and Career Development Grants [2004-present]
National Science Foundation [2007]
Walloon Excellence in Science and Biotechnology, Brussels, Belgium [2010]
Member, College of Reviewers for the Canada Research Chairs Program [2011-present]
Regular Member, Endocrinology A study section, Department of VA National Affiliate [2011-2015]
Member Research Career Scientist and PhD Promotions Panel, Department of VA [2013-present]
Fund for Scientific Research-FNRS, Brussels, Belgium [2014-present]
Member, Special Emphasis Panel-CTSA Innovation Grant Reviews. NCATS/NIH [2015]
 

Recent Publications

Publications since 2010 [from more than 160 peer-revied articles. Not included are more than 280 presentations at local, regional, national and international meetings]

Goalstone M, Kamath V and Kowluru A: Glucose activates prenyltransferases in pancreatic islet β-cells. Biochem Biophys Res Commun 391:895-898, 2010. [PMID: 19951701]

Kowluru A: Small G-proteins in islet β-cell function. Endocrine Reviews 31: 52-76, 2010 [PMID: 19890090]

Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch B: Protein farnesylation dependent Raf/ERK signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic β-cells. Diabetes 59:967-77, 2010 [PMID: 20071600]

Syed I, Jayaram B and Kowluru A: Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-dependent generation of oxidative stress in pancreatic β-cells. Biochem Pharmacol 80:874-83, 2010 [PMID: 20493824]

Kamath V, Kyathanahalli CN, Syed I, Jayaram B, Koch B, Ludwig K, Klumpp S, Krieglstein J and Kowluru A: A novel protein histidine phosphatase regulates glucose and mitochondrial fuel-induced insulin secretion in pancreatic β-cells Amer J Physiol-Endocrinol Metab 299:E276-86, 2010 [PMID: 20501872]

Du Y, Kowluru A, Kern TS: PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine. Amer Journal of Physiology Regulatory, Integrative and Comparative Physiology 299:R1610-7, 2010 [PMID: 20881100]

Subasinghe C, Syed I and Kowluru A: Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: Evidence for regulation by Rac1. Am J Physiol Regul Integr Comp Physiol. 300:R12-20, 2011[PMID: 20943855]

Jayaram B, Syed S, Singh A, Subasinghe W, Kyathanahalli CN, Kowluru A: Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells. Islets 3:1-10, 2011 [PMID: 21346419]

Kowluru A: Friendly, and not so friendly, roles of Rac1 in islet β-cell function: Lessons learnt from pharmacological and molecular biological approaches. Biochemical Pharmacology. 81:965-975, 2011 [PMID: 21300027]

Syed I, Kyathanahalli CN, Kowluru A: Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: Role of protein prenylation [2011] Am J Physiol Regul Integr Comp Physiol 300: R756-R762, 2011 [PMID: 21228337]

Jayaram B, Syed I, Kyathanahalli CN, Rhodes CJ, Kowluru A: Arf nucleotide binding site opener [ARNO] promotes the sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets. Biochemical Pharmacol 81:1016-1027, 2011 [PMID: 21276423]

Kowluru A, Klumpp S, Krieglstein J. Protein Histidine Kinases and Phosphatases in the Pancreatic Islet Beta-Cell: Evidence for Altered Expression and Function in Models of Glucolipotoxicity and Diabetes Naunyn-Schmiedeberg's Archives of Pharmacology 384:383-90, 2011 [PMID: 21626002]

Kyathanahalli CN, Kowluru A: A farnesylated pertussis toxin-sensitive G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets. Biochem Pharmacol. 81:1237-47, 2011 [PMID: 21406184]

Graciano MFR, Valle MMR, Kowluru A, Curi R, Carpinelli AR: Regulation of insulin secretion and production of reactive oxygen species by free fatty acids in pancreatic islets. Islets 3:1-11, 2011 [PMID: 21750413]

Syed I, Kyathanahalli CN, Jayaram B, Govind S, Rhodes CJ, Kowluru RA, Kowluru A: Increased phagocyte-like NADPH oxidase and ROS generation in type-2 diabetic ZDF rat and human islets: Roles of Rac1- JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes 60:2843-52, 2011 [PMID: 21911753]

Matti A, Kyathanahalli CN, Kowluru A: Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: Further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells. Islets 4:74-77, 2012 [PMID: 22504835]

Kowluru A, Matti A. Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: Underlying mechanisms and functional consequences. Biochemical Pharmacology 84: 591-597, 2012 [PMID:22583922]

Syed I, Szulc ZM, Ogretmen B and Kowluru A. L-threo-C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells. Cell Physiol Biochem 30:1051-1058, 2012 [PMID: 23052231]

Jayaram B, Kowluru A: Phagocytic NADPH oxidase links ARNO-Arf6 signaling pathway in glucose-stimulated insulin secretion from the pancreatic β-cell. Cell Physiol and Biochem 30:1351-1362, 2012. [PMID: 23095975]

Arora D, Syed I, Machhadieh B, McKenna CE, Kowluru A: Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β-cells. Islets 4:1-5, 2012 [PMID: 23114750]

Mohammed AM, Khadija S, Hadden T, Kowluru A. Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic β-cells: Attenuation of oxidative and nitrosative stress by 2-bromopalmitate. Biochemical Pharmacology 85:109-14, 2013 [PMID: 23092759]

Arora D, Mohammed AM, Kowluru A. Nifedipine prevents etoposide-induced caspase-3 activation and prenyl transferase degradation and loss in cell viability in pancreatic β-cells. Apoptosis 18:1-8, 2013 [PMID: 23054080]

Mohammed A, Chen F and Kowluru A: The Two Faces of Protein Palmitoylation in Islet β-Cell Function: Potential Implications in the Pathophysiology of Islet Metabolic Dysregulation and Diabetes. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 7:203-212, 2013 [PMID:23829395]

Mohammed A, Kowluru A: Activation of apocynin-sensitive NADPH oxidase (Nox2) activity in INS-1 832/13 cells under glucotoxic conditions. Islets 5:1-3, 2013 [PMID: 23695780]

Syeda K, Mohammed A, Arora DK and Kowluru A: Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine. Biochemical Pharmacology 86:1338-46, 2013 [PMID: 23994168]

Veluthakal R, Kaetzel D, Kowluru A: Nm23-H1 regulates glucose-stimulated insulin secretion in pancreatic beta-cells via Arf6-Rac1 signaling axis. Cell Physiol Biochem 32:533-541, 2013 [PMID: 24008651]

Wu K, Chang Q, Lu Y, Qiu P, Chen B, Thakur C, Sun J, Li L, Kowluru A and Chen F: Gefitinib resistance resulted from SATA3-mediated Akt activation in lung cancer cells. Oncotarget 12:2430-2438, 2013 [PMID:24280348]

Kowluru A and Kowluru RA: Phagocyte-like NADPH oxidase [Nox2] in cellular dysfunction in models of glucolipotoxicity and diabetes. Biochemical Pharmacol 88: 275-283, 2014 [PMID 2446291]

Arora DK, Machhadieh B, Matti A, Wadzinski B, Ramanadham S, Kowluru A: Hgh glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 cells by increasing the post-translational carboxylmethylation of its catalytic subunit. Endocrinology 155:380-91, 2014 [PMID: 24265448]

Kowluru A: Deoxysphingolipids: Beta-cell, beware of these new kids on the block. Diabetes 63:1191-1193, 2014 [PMID: 24651803]

Kowluru RA, Kowluru A, Veluthakal R, Mohammad G, Santos J, Mishra M: Tiam1-Rac1 signaling axis mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Diabetologia 57: 1047-56, 2014 [PMID:24554007]

Khadija S, Veluthakal R, Sidarala V, and Kowluru A: Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells. Apoptosis 19:1691-1701, 2014 [PMID: 25292013]

Kowluru A: On a sugary-relationship between caspases and lamins. Cell Cycle 13: 3787-3788, 2014 [PMID: 25470565]

Sidarala V, Veluthakal R, Khadija S, and Kowluru A: EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells. Cellular Signalling 27:1159-1167, 2015 [PMID: 25725286]

Sidarala V, Veluthakal R, Syeda K, Vlaar C, Newsholme P, and Kowluru A: Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1). Biochemical Pharmacology 95:301-10, 2015 [PMID: 257252]

Novak M, Leonard MK, Yang HH, Kowluru A, Belkin AM, Kaetzel DM: Metastasis Suppressor NME1 Regulates Melanoma Cell Morphology, Self-Adhesion and Motility via Induction of Fibronectin Expression. Experimental Dermatology 24:455-61, 2015. [PMID: 25808322].

Veluthakal R, Kumar B, Mohammad G, Kowluru A and Renu A. Kowluru Tiam1-Rac1 axis promotes activation of p38 MAP kinase in the development of diabetic retinopathy: Evidence for a requisite role for protein palmitoylation. Cell Physiol Biochem 36:208-20, 2015. [PMID: 25967961].

Kowluru R, Kowluru A and Kumar B: Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci 56:2985-92, 2015. [PMID: 26024084].

Kowluru RA, Kowluru A, Mishra M, and Kumar B: Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy. Progress in Retinal and Eye Research 48:40-61, 2015 [PMID: 25975734]

Fang J, Liu M, Sakamoto T, Zhang X, Taatjes D, Jena BP, Kowluru A, Zhang K, Chen X: COPII dependent ER export: a critical component of insulin biogenesis and beta cell ER homeostasis. Mol Endocrinol 29:1156-69, 2015 [PMID: 26083833]

Veluthakal R, Tunduguru R, Arora DK, Sidarala V, Syeda K, Vlaar CP, Thurmond DC, and Kowluru A. Vav2, a guanine nucleotide exchange factor for Ras-related C3 botulinum toxin substrate 1 (Rac1), regulates glucose-stimulated insulin secretion in pancreatic β-cells Diabetologia. 58:2573-81, 2015 [PMID: 26224100]

Kowluru A and Kowluru RA: Protein prenylation in islet β-cell function in health and diabetes: Putting the pieces of the puzzle together. Biochemical Pharmacology 98:363-70, 2015. [PMID: 26215874]

Syeda K, Chen F, Hadden T, Commissaris R, Kowluru A. Nuclear lamins in islet β-cell function. Recent Patents on Endocrine Metabolic and Immune Drug Discovery 9:111-120, 2015. [PMID: 26453024]

Kowluru A. A lack of glue misplaces Rab27A to cause islet dysfunction in diabetes. J Pathol 238:375-377, 2016. [PMID:26575346]

Zhang X, Damacharla D, Ma D, Qi Y, Tagett R, Draghici S, Kowluru A, and Yi Z: Quantitative mass spectrometric identification of protein interaction partners of the catalytic subunit of protein phosphatase 2A in pancreatic β-cells. Molecular and Cellular Endocrinology 424:1-11, 2016 [PMID: 26780722]

Veluthakal R, Sidarala V, Kowluru A: NSC23766, a known inhibitor of Tiam1-Rac1 signaling module, prevents the onset of type 1 diabetes in the NOD mouse model. Cell Physiol Biochem 39:760-767, 2016. [PMID: 27467102]

Kowluru RA, Mishra M, Kowluru A, Kumar B: hyperlipidemia and the development of diabetic retinopathy: Comparison between type1 and type 2 animal models. Metabolism 65:1570-1581, 2016. [PMID:27621192]

Veluthakal R, Arora DK, Goalstone ML, Kowluru RA and Kowluru A: Metabolic stress induces caspase-3 mediated degradation and inactivation of farnesyl and geranylgeranyl transferase activities in pancreatic β-cells. Cell Physiol Biochem 39:2110-2120, 2016. [PMID: 27802439]

Sidarala V and Kowluru A: The regulatory roles of mitogen-activated protein kinase (MAPK) pathways in health and diabetes: Lessons learnt from the pancreatic beta-cell Recent Patents on Endocrine, Metabolic and Immune Drug Discovery 10: 76-84, 2016. [PMID: 27779078]

Kowluru A. Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction. Biochemical Pharmacology 132:9-17, 2017 [PMID:28202288]

Sidarala V and Kowluru A. Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 [Rac1]-mediated activation of p53 and ATM kinase in pancreatic β-cells. Apoptosis 22: 597-607, 2017 [PMID:28220272].

Kowluru A. Role of G-proteins in islet function in health and diabetes. Diabetes Obes Metab [2017] in press.

 

Active Research Support

1101BX002801 [Department of VA MERIT Review Grant]
Duration: 07/01/2015-06/30/2019
Title: Novel Regulators of Islet β-Cell Function in Health and Diabetes
Objective: To investigate novel regulatory roles of guanine nucleotide exchange factors in the activation of specific G-proteins in islet beta cell function in health and diabetes. [Continuous support for years 23-27].
Role: PI

13S-RCS-006 [Department of VA-SRCS Award]
Duration: 09/01/2013-03/31/2020
Senior Research Career Scientist Award [Continuous support from the VA for years 13-20].
Role: PI

5RO1EY022230-04 [NIH/NEI]
Duration: 04/01/2012-03/31/2018
Title: NADPH Oxidase, Mitochondrial Dysfunction and Diabetic Retinopathy
Objective: To examine the roles of NADPH oxidase-derived reactive oxygen species in the onset of mitochondrial dysfunction and demise of retinal capillary endothelial cells leading to the onset of diabetic retinopathy.
Role: PI [Multi-PI award with Dr. Renu Kowluru]

2R01DK081750-05 [NIH/NIDDK]
Duration: 08/01/2014-04/30/2018
Title: Human Skeletal Muscle Proteome & Phosphoproteome in Obesity and Type 2 diabetes
Objective: To determine functional regulation of PP2A in human skeletal muscle in obesity and type 2 diabetes.
Role: Co-I [Dr. Zhengping Yi; PI]

1R01DK107666-01 [NIH/NIDDK]
Duration: 09/25/2015-08/31/2020
Title: Serine/threonine Protein Phosphatase 1 in Insulin resistance and Type 2 Diabetes
Objective: To investigate the role of protein phosphatase1 regulatory subunit 12 in human skeletal muscle insulin resistance and type 2 diabetes.
Role: Co-I [Dr. Zhengping Yi; PI]

1 R01 DK110314-01 [NIH/NIDDK]
Duration: 09/01/2016-08/31/2021
Title: Proinsulin ER export and β-cell ER homeostasis in health and diabetes
Objective: To determine mechanisms underlying proinsulin ER export and beta cell ER homeostasis in health and diabetes.
Role: Co-I [Dr. Xuequn Chen; PI]

5101BX001019-02 [Department of VA]
Duration: 04/01/2014-03/31/2018
Title: Diabetes ERK5 and Vascular Inflammation
Objective: To examine contributory roles of ERK5 signaling pathway in vascular inflammation in diabetes
Role: Co-I [Dr. Marc Goalstone; PI]

 

Link for complete list of publications

https://www.ncbi.nlm.nih.gov/pubmed/?term=kowluru+a+or+anjaneyulu+k


 

 

 

 

 

 

Research Connect link

https://researchconnect.wayne.edu/en/persons/anjaneyulu-kowluru

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