Anjaneyulu Kowluru Ph.D.

Anjaneyulu Kowluru Ph.D.

Distinguished Professor

Contact

313-577-5490
akowluru@med.wayne.edu

Office location

EACPHS, Room 3617

Department

Pharmaceutical Sciences

Appointments

Distinguished Professor

Degrees and Certifications

  • B.Sc [Botany, Zoology and Chemistry] Andhra University, India
  • M.Sc [Agricultural Biochemistry] Allahabad University, India
  • Ph.D. [Biochemistry] Indian Institute of Technology, Delhi, India
  • Post-Doctoral Fellow, Brussels Free University School of Medicine, Brussels, Belgium
  • JDRF Fellow, University of Wisconsin School of Medicine, Madison, WI, USA

Positions and Employment

  • Staff Scientist, Division of Life Sciences, Los Alamos National Laboratory, Los Alamos, NM [1984-1991]
  • Senior Scientist, Department of Medicine, University of Wisconsin-Madison, and Health Science Specialist, VA
  • Medical Center-Madison, WI [1991-1998]
  • Associate Professor, Department of Pharmaceutical Sciences, Wayne State University, and Research Scientist, VA Medical Center-Detroit [1998-2001]
  • Research Career Scientist-VA Medical Center-Detroit [2001-2006]
  • Professor-Transplant Program, Department of Surgery, Wayne State University and Professor [with tenure], Department of Pharmaceutical Sciences, Wayne State University [2001-present]
  • Senior Research Career Scientist, John D. Dingell VA Medical Center, Detroit [2004-present]
  • Member, Michigan Diabetes Research and Training Center [2001-present]
  • Chair, Research and Development Committee, JDD VA Medical Center, Detroit [2012-2014]
  • Associate Dean for External Scientific Affairs, College of Pharmacy, Wayne State University [2011-2017]
  • Adjunct Professor, School of Biomedical Sciences, Curtin University, Perth, Australia [2013-present]
  • Adjunct Professor, Interdisciplinary Science and Technology Research Academy, University of Pune, India
  • [2014-present]
  • Member, Diabetes and Obesity Team Science Group, Wayne State University, Detroit [2014-present]
  • Deputy ACOS-R&D, John D. Dingell VA Medical Center, Detroit [2015-2016]
  • Acting ACOS-R&D, John D. Dingell VA Medical Center, Detroit [2016-2017]

Awards and Honors

  • Junior and Senior Research Fellowships, Council of Scientific and Industrial Research, India [1974-1979] Fellow of the Belgian Institute for Research in Scientific Industry and Agriculture, Belgium [1979-1981]
  • Fellow, Juvenile Diabetes Research Foundation [1982-1984]
  • Coordinator, Diabetes Research Training Program, VA Medical Center, Detroit [2001-2015]
  • Visiting Professor [Burroughs Wellcome Trust], University of Keele, Staffordshire, UK [2001]
  • Visiting Professor, National University of Singapore, Singapore [2001]
  • Board of Governors Charles H. Gershenson Distinguished Faculty Fellow [2004]
  • Elected Member-WSU Academy of Scholars [2006]
  • Visiting Professor, University of Dundee, Scotland [2006]
  • Bayard D. Catherwood Memorial Lecture, Emory University School of Medicine [2010]
  • Visiting Professor, Curtin University, Perth, Western Australia [2014]
  • Professor, Interdisciplinary Science and Technology Research Academy, University of Pune, India [2014]
  • Distinguished Graduate Faculty Award, Wayne State University [2015]
  • Distinguished Professor, Wayne State University [2017]
  • President, Wayne State University Academy of Scholars [2018-19]  

Professional Memberships

Current Membership in Professional Societies

  • American Diabetes Association
  • American Society of Biochemistry and Molecular Biology
  • American Society for Cell Biology
  • Association for Research in Vision and Ophthalmology
  • American Physiological Society
  • American Association for Pharmaceutical Scientists
  • Endocrine Society
  • European Association for the Study of Diabetes
  • Islet Society
  • Alpha Chi Chapter on National Pharmacy Honor Society, Wayne State University
  • Life member, Atherosclerosis Society-India
  • Life Member, Research Society for the Study of Diabetes-India
  • Life Member, Free Radical Society-India
  • Society for Free Radical Biology and Medicine
  • AAPS-Clinical Pharmacology and Translational Research Section
  • AAPS-Drug Discovery and Development Interface Section

Membership- Journal Editorial Boards

  • Endocrinology [2000-04]
  • American Journal of Physiology: Endocrinology and Metabolism [2000-2012]
  • Associate Editor, Experimental Diabetes Research [2008-2011]
  • Regional Editor, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery [2005-present]
  • Biochemical Pharmacology [2007-present]
  • Islets [2008-present]
  • Review Editor, Frontiers in Endocrinology [2013-present]
  • The Open Enzyme Inhibition Journal [2007-present]
  • The Open Nitric Oxide Journal [2007-2010]
  • Metabolic and Functional Research on Diabetes [2008-present]
  • JOP- Journal of Pancreas [2009-present]
  • Journal of Membrane Science and Technology [2010-present]
  • Journal of Diabetes and Metabolism [2010-present]
  • OA Diabetes [London; 2013-present]
  • International Journal of Diabetology and Vascular Disease Research [2013-present]
  • American Journal of Physiology-Endocrinology and Metabolism [2015-present]

Manuscript Reviewer- Peer Reviewed Journals

  • Acta Diabetologica
  • American J of Physiology
  • Biochemistry
  • Biochemistry and Cell Biology
  • Biochemical Pharmacology
  • Biochimica Biophysica Acta
  • Cellular Physiology and Biochemistry
  • Diabetes
  • Diabetologia
  • Endocrinology
  • Endocrine
  • Endocrine Metabolism and Immune Drug Discovery
  • Endocrine Research
  • Expert Review of Endocrinology and Metabolism
  • European Journal of Pharmacology
  • FEBS Letters
  • Hormone and Metabolic Research
  • International Journal of Experimental Diabetes Research
  • International Journal of Biochemistry and Cell Biology
  • Journal of Biomedicine and Biotechnology
  • Journal of Cell Science
  • Journal of Diabetes Research
  • Journal of Endocrinology
  • Journal of Free Radical Biology and Medicine
  • Journal of Histochemistry and Cytochemistry
  • Journal of Molecular Endocrinology
  • Journal of Nutrition
  • Journal of Nutrition and Metabolism
  • Journal of Molecular and Cellular Biochemistry
  • Journal of Pathology
  • Journal of Pancreas
  • Journal of Toxicology
  • Lipids
  • Metabolism
  • Molecular and Cellular Biochemistry
  • Molecular and Cellular Endocrinology
  • Molecular Endocrinology
  • Molecular Pharmaceutics
  • Pancreas
  • Proceedings of National Academy of Sciences, USA
  • Plos ONE
  • Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
  • Scientific Reports [Nature Publishing]
  • Toxicology and Applied Pharmacology

Membership on Grant Review Panels

  • Regular member, American Diabetes Association; National Affiliate [1999-2002]
  • Endocrinology Subcommittee - Department of VA [2000-2003]
  • Regular member, Department of VA Non-Clinician Eligibility Review Panel [2008-2010]
  • Special Emphasis Review Panel-Nutrition and Metabolic Sciences NIDDK [1999-2001]
  • Innovative Partnerships in type 1 Diabetes NIDDK [2004]
  • Cellular Aspects of Diabetes and Obesity; NIDDK [2007-2008]
  • Medical Research Review Committee, Juvenile Diabetes Research Foundation [2008-2011]
  • Research Grant Council of Hong Kong [2011]
  • Regular member Cellular Aspects of Diabetes and Obesity Study Section NIDDK [2008-2012]
  • Diabetes UK Program [2003-present]
  • Burroughs Wellcome Trust [2004]
  • Department of VA Merit Review and Career Development Grants [2004-present]
  • National Science Foundation [2007]
  • Walloon Excellence in Science and Biotechnology, Brussels, Belgium [2010]
  • Member, College of Reviewers for the Canada Research Chairs Program [2011-present]
  • Regular Member, Endocrinology A study section, Department of VA National Affiliate [2011-2015]
  • Member Research Career Scientist and PhD Promotions Panel, Department of VA [2013-present]
  • Fund for Scientific Research-FNRS, Brussels, Belgium [2014-present]
  • Member, Special Emphasis Panel-CTSA Innovation Grant Reviews. NCATS/NIH [2015]
  • Member, PhD Promotions and S/RCS Evaluations Panel, Department of VA  [2011-present]
  • Member, RCS Advisory Committee, Department of VA [2018-19] 
  • Reviewer, King Abdulaziz City For Science and Technology [2018]
  • Reviewer, Czech Science Foundation [2018]

Areas of Expertise

  • G-protein-mediated signal transduction mechanisms
  • Post-translational modification of proteins, including prenylation, carboxylmethylation, palmitoylation, phosphorylation and dephosphorylation                                                                                             

Primary Research Interest

Molecular and cellular mechanisms underlying islet beta-cell function in health and diabetes.

Recent Publications

Select publications [from more than 170 peer-revied articles. Not included are more than 300 presentations at local, regional, national and international meetings]

Goalstone M, Kamath V and Kowluru A: Glucose activates prenyltransferases in pancreatic islet β-cells. Biochem Biophys Res Commun 391:895-898, 2010. [PMID: 19951701]

Kowluru A: Small G-proteins in islet β-cell function. Endocrine Reviews 31: 52-76, 2010 [PMID: 19890090]

Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch B: Protein farnesylation dependent Raf/ERK signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic β-cells. Diabetes 59:967-77, 2010 [PMID: 20071600]

Syed I, Jayaram B and Kowluru A: Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-dependent generation of oxidative stress in pancreatic β-cells. Biochem Pharmacol 80:874-83, 2010 [PMID: 20493824]

Kamath V, Kyathanahalli CN, Syed I, Jayaram B, Koch B, Ludwig K, Klumpp S, Krieglstein J and Kowluru A: A novel protein histidine phosphatase regulates glucose and mitochondrial fuel-induced insulin secretion in pancreatic β-cells Amer J Physiol-Endocrinol Metab 299:E276-86, 2010 [PMID: 20501872]

Du Y, Kowluru A, Kern TS: PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine. Amer Journal of Physiology Regulatory, Integrative and Comparative Physiology 299:R1610-7, 2010 [PMID: 20881100]

Subasinghe C, Syed I and Kowluru A: Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: Evidence for regulation by Rac1. Am J Physiol Regul Integr Comp Physiol. 300:R12-20, 2011[PMID: 20943855]

Jayaram B, Syed S, Singh A, Subasinghe W, Kyathanahalli CN, Kowluru A: Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells. Islets 3:1-10, 2011 [PMID: 21346419]

Kowluru A: Friendly, and not so friendly, roles of Rac1 in islet β-cell function: Lessons learnt from pharmacological and molecular biological approaches. Biochemical Pharmacology. 81:965-975, 2011 [PMID: 21300027]

Syed I, Kyathanahalli CN, Kowluru A: Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: Role of protein prenylation [2011] Am J Physiol Regul Integr Comp Physiol 300: R756-R762, 2011 [PMID: 21228337]

Jayaram B, Syed I, Kyathanahalli CN, Rhodes CJ, Kowluru A: Arf nucleotide binding site opener [ARNO] promotes the sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets. Biochemical Pharmacol 81:1016-1027, 2011 [PMID: 21276423]

Kowluru A, Klumpp S, Krieglstein J. Protein Histidine Kinases and Phosphatases in the Pancreatic Islet Beta-Cell: Evidence for Altered Expression and Function in Models of Glucolipotoxicity and Diabetes Naunyn-Schmiedeberg's Archives of Pharmacology 384:383-90, 2011 [PMID: 21626002]

Kyathanahalli CN, Kowluru A: A farnesylated pertussis toxin-sensitive G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets. Biochem Pharmacol. 81:1237-47, 2011 [PMID: 21406184]

Graciano MFR, Valle MMR, Kowluru A, Curi R, Carpinelli AR: Regulation of insulin secretion and production of reactive oxygen species by free fatty acids in pancreatic islets. Islets 3:1-11, 2011 [PMID: 21750413]

Syed I, Kyathanahalli CN, Jayaram B, Govind S, Rhodes CJ, Kowluru RA, Kowluru A: Increased phagocyte-like NADPH oxidase and ROS generation in type-2 diabetic ZDF rat and human islets: Roles of Rac1- JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes 60:2843-52, 2011 [PMID: 21911753]

Matti A, Kyathanahalli CN, Kowluru A: Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: Further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells. Islets 4:74-77, 2012 [PMID: 22504835]

Kowluru A, Matti A. Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: Underlying mechanisms and functional consequences. Biochemical Pharmacology 84: 591-597, 2012 [PMID:22583922]

Syed I, Szulc ZM, Ogretmen B and Kowluru A. L-threo-C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells. Cell Physiol Biochem 30:1051-1058, 2012 [PMID: 23052231]

Jayaram B, Kowluru A: Phagocytic NADPH oxidase links ARNO-Arf6 signaling pathway in glucose-stimulated insulin secretion from the pancreatic β-cell. Cell Physiol and Biochem 30:1351-1362, 2012. [PMID: 23095975]

Arora D, Syed I, Machhadieh B, McKenna CE, Kowluru A: Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β-cells. Islets 4:1-5, 2012 [PMID: 23114750]

Mohammed AM, Khadija S, Hadden T, Kowluru A. Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic β-cells: Attenuation of oxidative and nitrosative stress by 2-bromopalmitate. Biochemical Pharmacology 85:109-14, 2013 [PMID: 23092759]

Arora D, Mohammed AM, Kowluru A. Nifedipine prevents etoposide-induced caspase-3 activation and prenyl transferase degradation and loss in cell viability in pancreatic β-cells. Apoptosis 18:1-8, 2013 [PMID: 23054080]

Mohammed A, Chen F and Kowluru A: The Two Faces of Protein Palmitoylation in Islet β-Cell Function: Potential Implications in the Pathophysiology of Islet Metabolic Dysregulation and Diabetes. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 7:203-212, 2013 [PMID:23829395]

Mohammed A, Kowluru A: Activation of apocynin-sensitive NADPH oxidase (Nox2) activity in INS-1 832/13 cells under glucotoxic conditions. Islets 5:1-3, 2013 [PMID: 23695780]

Syeda K, Mohammed A, Arora DK and Kowluru A: Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine. Biochemical Pharmacology 86:1338-46, 2013 [PMID: 23994168]

Veluthakal R, Kaetzel D, Kowluru A: Nm23-H1 regulates glucose-stimulated insulin secretion in pancreatic beta-cells via Arf6-Rac1 signaling axis. Cell Physiol Biochem 32:533-541, 2013 [PMID: 24008651]

Wu K, Chang Q, Lu Y, Qiu P, Chen B, Thakur C, Sun J, Li L, Kowluru A and Chen F: Gefitinib resistance resulted from SATA3-mediated Akt activation in lung cancer cells. Oncotarget 12:2430-2438, 2013 [PMID:24280348]

Kowluru A and Kowluru RA: Phagocyte-like NADPH oxidase [Nox2] in cellular dysfunction in models of glucolipotoxicity and diabetes. Biochemical Pharmacol 88: 275-283, 2014 [PMID 2446291]

Arora DK, Machhadieh B, Matti A, Wadzinski B, Ramanadham S, Kowluru A: Hgh glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 cells by increasing the post-translational carboxylmethylation of its catalytic subunit. Endocrinology 155:380-91, 2014 [PMID: 24265448]

Kowluru A: Deoxysphingolipids: Beta-cell, beware of these new kids on the block. Diabetes 63:1191-1193, 2014 [PMID: 24651803]

Kowluru RA, Kowluru A, Veluthakal R, Mohammad G, Santos J, Mishra M: Tiam1-Rac1 signaling axis mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Diabetologia 57: 1047-56, 2014 [PMID:24554007]

Khadija S, Veluthakal R, Sidarala V, and Kowluru A: Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells. Apoptosis 19:1691-1701, 2014 [PMID: 25292013]

Kowluru A: On a sugary-relationship between caspases and lamins. Cell Cycle 13: 3787-3788, 2014 [PMID: 25470565]

Sidarala V, Veluthakal R, Khadija S, and Kowluru A: EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells. Cellular Signaling 27:1159-1167, 2015 [PMID: 25725286]

Sidarala V, Veluthakal R, Syeda K, Vlaar C, Newsholme P, and Kowluru A: Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1). Biochemical Pharmacology 95:301-10, 2015 [PMID: 257252]

Novak M, Leonard MK, Yang HH, Kowluru A, Belkin AM, Kaetzel DM: Metastasis Suppressor NME1 Regulates Melanoma Cell Morphology, Self-Adhesion and Motility via Induction of Fibronectin Expression. Experimental Dermatology 24:455-61, 2015. [PMID: 25808322].

Veluthakal R, Kumar B, Mohammad G, Kowluru A and Renu A. Kowluru Tiam1-Rac1 axis promotes activation of p38 MAP kinase in the development of diabetic retinopathy: Evidence for a requisite role for protein palmitoylation. Cell Physiol Biochem 36:208-20, 2015. [PMID: 25967961].

Kowluru R, Kowluru A and Kumar B: Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci 56:2985-92, 2015. [PMID: 26024084].

Kowluru RA, Kowluru A, Mishra M, and Kumar B: Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy. Progress in Retinal and Eye Research 48:40-61, 2015 [PMID: 25975734]

Fang J, Liu M, Sakamoto T, Zhang X, Taatjes D, Jena BP, Kowluru A, Zhang K, Chen X: COPII dependent ER export: a critical component of insulin biogenesis and beta cell ER homeostasis. Mol Endocrinol 29:1156-69, 2015 [PMID: 26083833]

Veluthakal R, Tunduguru R, Arora DK, Sidarala V, Syeda K, Vlaar CP, Thurmond DC, and Kowluru A. Vav2, a guanine nucleotide exchange factor for Ras-related C3 botulinum toxin substrate 1 (Rac1), regulates glucose-stimulated insulin secretion in pancreatic β-cells Diabetologia. 58:2573-81, 2015 [PMID: 26224100]

Kowluru A and Kowluru RA: Protein prenylation in islet β-cell function in health and diabetes: Putting the pieces of the puzzle together. Biochemical Pharmacology 98:363-70, 2015. [PMID: 26215874]

Syeda K, Chen F, Hadden T, Commissaris R, Kowluru A. Nuclear lamins in islet β-cell function. Recent Patents on Endocrine Metabolic and Immune Drug Discovery 9:111-120, 2015. [PMID: 26453024]

Kowluru A. A lack of glue misplaces Rab27A to cause islet dysfunction in diabetes. J Pathol 238:375-377, 2016. [PMID:26575346]

Zhang X, Damacharla D, Ma D, Qi Y, Tagett R, Draghici S, Kowluru A, and Yi Z: Quantitative mass spectrometric identification of protein interaction partners of the catalytic subunit of protein phosphatase 2A in pancreatic β-cells. Molecular and Cellular Endocrinology 424:1-11, 2016 [PMID: 26780722]

Veluthakal R, Sidarala V, Kowluru A: NSC23766, a known inhibitor of Tiam1-Rac1 signaling module, prevents the onset of type 1 diabetes in the NOD mouse model. Cell Physiol Biochem 39:760-767, 2016. [PMID: 27467102]

Kowluru RA, Mishra M, Kowluru A, Kumar B: hyperlipidemia and the development of diabetic retinopathy: Comparison between type1 and type 2 animal models. Metabolism 65:1570-1581, 2016. [PMID:27621192]

Veluthakal R, Arora DK, Goalstone ML, Kowluru RA and Kowluru A: Metabolic stress induces caspase-3 mediated degradation and inactivation of farnesyl and geranylgeranyl transferase activities in pancreatic β-cells. Cell Physiol Biochem 39:2110-2120, 2016. [PMID: 27802439]

Sidarala V and Kowluru A: The regulatory roles of mitogen-activated protein kinase (MAPK) pathways in health and diabetes: Lessons learnt from the pancreatic beta-cell Recent Patents on Endocrine, Metabolic and Immune Drug Discovery 10: 76-84, 2016. [PMID: 27779078]

Kowluru A. Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction. Biochemical Pharmacology 132:9-17, 2017 [PMID:28202288]

Sidarala V and Kowluru A. Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 [Rac1]-mediated activation of p53 and ATM kinase in pancreatic β-cells. Apoptosis 22: 597-607, 2017 [PMID:28220272].

Kowluru A. Role of G-proteins in islet function in health and diabetes. Diabetes Obes Metab 19 (supplement 1) 63-75, 2017 [PMID:28880478]

Kowluru A, Kowluru RA. RACking up ceramide-induced islet beta-cell function. Biochem Pharmacol 154:161-169, 2018 [PMID:29715450]

 

Active Research Support

1101BX002801 [Department of VA MERIT Review Grant]
Duration: 07/01/2015-06/30/2019
Title: Novel Regulators of Islet β-Cell Function in Health and Diabetes
Objective: To investigate novel regulatory roles of guanine nucleotide exchange factors in the activation of specific G-proteins in islet beta cell function in health and diabetes. [Continuous support for years 23-27].
Role: PI

13S-RCS-006 [Department of VA-SRCS Award]
Duration: 09/01/2013-03/31/2020
Senior Research Career Scientist Award [Continuous support from the VA for years 13-20].
Role: PI

5RO1EY022230-04 [NIH/NEI]
Duration: 04/01/2012-02/28/2023
Title: NADPH Oxidase, Mitochondrial Dysfunction and Diabetic Retinopathy
Objective: To examine the roles of NADPH oxidase-derived reactive oxygen species in the onset of mitochondrial dysfunction and demise of retinal capillary endothelial cells leading to the onset of diabetic retinopathy.
Role: PI [Multi-PI award with Dr. Renu Kowluru]

2R01DK081750-05 [NIH/NIDDK]
Duration: 08/01/2014-04/30/2018 (NCE)
Title: Human Skeletal Muscle Proteome & Phosphoproteome in Obesity and Type 2 diabetes
Objective: To determine functional regulation of PP2A in human skeletal muscle in obesity and type 2 diabetes.
Role: Co-I [Dr. Zhengping Yi; PI]

1R01DK107666-01 [NIH/NIDDK]
Duration: 09/25/2015-08/31/2020
Title: Serine/threonine Protein Phosphatase 1 in Insulin resistance and Type 2 Diabetes
Objective: To investigate the role of protein phosphatase1 regulatory subunit 12 in human skeletal muscle insulin resistance and type 2 diabetes.
Role: Co-I [Dr. Zhengping Yi; PI]

1 R01 DK110314-01 [NIH/NIDDK]
Duration: 09/01/2016-08/31/2021
Title: Proinsulin ER export and β-cell ER homeostasis in health and diabetes
Objective: To determine mechanisms underlying proinsulin ER export and beta cell ER homeostasis in health and diabetes.
Role: Co-I [Dr. Xuequn Chen; PI]

Link for complete list of publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=kowluru+a+or+anjaneyulu+k  

Research Connect link

https://www.ncbi.nlm.nih.gov/pubmed/?term=kowluru+a+or+anjaneyulu+k

Return to profile list