Wayne State University

Aim Higher

Faculty Biography

Steven M. Firestine, PhD

(313) 577-0455

EACPHS Room 3142


Associate Professor, Department of Pharmaceutical Sciences

Education Training

B.S. Chemistry - University of Michigan, Ann Arbor MI
PhD. Medicinal Chemistry - Purdue University, West Lafayette IN
Postdoc Enzymology - Pennsylvania State University, University Park PA

Positions and Employment

1988-1990      Undergraduate Research Assistant (Dr. James K. Coward),  University of   Michigan,

                     Ann Arbor, MI

1990-1995      Graduate Research Assistant (Dr. V. Jo Davission), Purdue University , West Lafayette, IN

1996-2000      Postdoctoral Fellow (Dr. Stephen J. Benkovic), The Pennsylvania State University,

                     University Park, PA

2000-2005            Assistant Professor of Medicinal Chemistry, Duquesne University Mylan School of Pharmacy, Pittsburgh PA

2005-2010            Assistant Professor of Medicinal Chemistry, Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI

2010-present  Associate Professor of Medicinal Chemistry, Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI

Awards and Honors

1989              Gomberg Summer Research Fellowship, University of Michigan

1990              Merck Award, University of Michigan

1992-1993      NIH Predoctoral Training grant, Purdue University

1994-1995      American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship,

                     Purdue University

1995              Jenkins/Knevel Award for Outstanding Graduate Research, Purdue University

1996-1999      Damon Runyon-Walter Winchell Fellowship, Penn State

1999              ASBMB   Travel Award, Penn State

2005              Outstanding Young Investigator, Duquesne University

Recent Publications

34. Vooturi, S.K. and Firestine, S.M. Synthetic Membrane-Targeted Antibiotics. Curr. Med. Chem.,. 2010, 17, 2292-2300.

33. Thoden, J.B., Holden, H.M., Paritala, H., and Firestine, S.M. Structure and Site-Directed Mutagenesis of Aspergillus clavatus N5-Carboxylaminoimidazole Ribonucleotide Synthetase. Biochemistry, 2010, 49, 752-60.

32. Paritala, H. and Firestine, S.M. Characterization of insulin ILPR sequences for their ability to adopt a G-quadruplex structure. Nucleosides Nucleotides Nucleic Acids, 2010, 29, 81-90.

31. Vooturi, S.K. and Firestine, S.M.* Solution-Phase Parallel Synthesis of Novel Membrane-Targeted Antibiotics. J. Comb. Chem., 2010, 12, 151-160.

30. Vooturi, S.K., Cheung, C.M. Rybak, M.J., and Firestine, S.M.* Design, Synthesis, and Structure-Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents. J. Med. Chem., 52, 5020-5031, 2009.

29. Paritala, H., and Firestine, S.M.* Benzo(h)quinoline derivatives as G-quadruplex binding agents. Bio. Med. Chem. Let., 19, 1584-1587, 2009.

28. Firestine, S.M.*, Paritala, H., McDonnell, J.E., Thoden, J. and Holden, H.M. Identification of Inhibitors of N5-Carboxylaminoimidazole Ribonucleotide Synthetase by High-throughput Screening. Bio. Med. Chem., 17, 3317-3323, 2009.

27. Firestine, S.M.*, Wu, W., Youn, H. and Davisson, V.J. Interrogating the Mechanism of a Tight Binding Inhibitor of AIR Carboxylase. Bio. Med. Chem., 17, 794-803, 2009.

26. Thoden, J.B., Holden, H.M.* and Firestine, S.M.* Structural Analysis of the Active Site Geometry of N5-Carboxyaminoimidazole Ribonucleotide Synthetase from Escherichia coli. Biochemistry, 47, 1334613353, 2008.

25. Mamidyala, S.K. and Firestine, S.M.* Advances in Herpes Simplex Virus Antiviral Therapy, Expert Opinions in Therapeutic Patents, 16, 1463-1480, 2006.

24. Mamidyala, S.K. and Firestine, S.M.* Fluorous-phase synthesis of minor groove binding agents related to distamycin, Tet. Let., 47, 7431-7434, 2006.

23. Bednarski, D. and Firestine, S.M. * Regulation of transcription by synthetic DNA bending agents. ChemBioChem, 7, 1715-1721, 2006.

22. Mueller Stein, S.A., Loccisano, A.E., Firestine, S.M. and Evanseck, J.D.* Principal component analysis: a review of its application on molecular dynamics data. Ann. Rep. Comp. Chem., 2, 234-255, 2006.

21. Hooda, J. Bednarski, D., Irish, L. and Firestine, S.M.* Synthesis and testing of a Triaza-Cyclopenta[b]phenanthrene scaffold as a DNA binding agent. Bio. Med. Chem. 14, 1902-1909, 2006.

Poster and Oral Presentations: Over 75 presentations.

Primary Research Interest

Antiinfective Drug Discovery; Organic Chemistry; Biochemistry; Chemical Biology